N-demethylhuperzinine
IC50 AChE 0.89 +/- 0.13 BChE 1.86 +/- 0.16
General
Type : Derivative of Huperzine, Natural
Chemical_Nomenclature : (1R,9R,13R)-13-ethenyl-11-methyl-1-(methylamino)-6-azatricyclo[7.3.1.02,7]trideca-2(7),3,10-trien-5-one
Canonical SMILES : CC1=CC2CC3=C(C=CC(=O)N3)C(C1)(C2C=C)NC
InChI : InChI=1S\/C16H20N2O\/c1-4-12-11-7-10(2)9-16(12,17-3)13-5-6-15(19)18-14(13)8-11\/h4-7,11-12,17H,1,8-9H2,2-3H3,(H,18,19)\/t11-,12+,16+\/m0\/s1
InChIKey : GSNAOXZKMHHMJN-HWWQOWPSSA-N
Other name(s) : CHEMBL448799, BDBM50438366
MW : 256.34
Formula : C16H20N2O
CAS_number :
PubChem : 10264399
UniChem : GSNAOXZKMHHMJN-HWWQOWPSSA-N
Target
Families : N-demethylhuperzinine ligand of proteins in family
BCHE
ACHE
Protein :
human-BCHE
human-ACHE
References (4)
| Title : Lycodine-type alkaloids from Lycopodiastrum casuarinoides and their acetylcholinesterase inhibitory activity - Feng_2019_Fitoterapia__104378 |
| Author(s) : Feng Z , Chen S , Wang W , Feng L , Dong Y , Zou Y , Ke C , Tang C , Yao S , Zhang H , Gan L , Ye Y , Lin L |
| Ref : Fitoterapia , :104378 , 2019 |
| PubMedID: 31676395 |
| Title : Lycodine-type alkaloids from Lycopodium casuarinoides - Yin_2006_Helv.Chim.Acta_89_138 |
| Author(s) : Yin S , Fan CQ , Wang XN , Yue JM |
| Ref : Helv Chim Acta , 89 :138 , 2006 |
| PubMedID: |
| Title : Alkaloids from Lycopodium casuarinoides - Shen_1994_J.Nat.Prod_57_824 |
| Author(s) : Shen YC , Chen CH |
| Ref : Journal of Natural Products , 57 :824 , 1994 |
| PubMedID: 7931368 |