N-ethyl-Carltonine-B
hBChE IC50 = 0.013 +/- 0.001 microM;. Noncompetitive inhibition with Ki value of 0.065 microM
General
Type : Alkaloid, Natural_modified
Chemical_Nomenclature :
Canonical SMILES : C12=CC(=C(C=C1OCO2)CN(CCC3=CC=C(C=C3)O)CC)C4=CC=CC5=C4N(CC5)C
InChI : InChI=1S\/C27H30N2O3\/c1-3-29(14-11-19-7-9-22(30)10-8-19)17-21-15-25-26(32-18-31-25)16-24(21)23-6-4-5-20-12-13-28(2)27(20)23\/h4-10,15-16,30H,3,11-14,17-18H2,1-2H3
InChIKey : KEUYNHRQQKJWDJ-UHFFFAOYSA-N
Other name(s) : Compound 38
Target
References (1)
| Title : Carltonine B derivatives: Synthesis and structure-activity relationship insights for selective butyrylcholinesterase inhibition - Al Mamun_2026_Bioorg.Chem_177_109894 |
| Author(s) : Al Mamun A , Konecny J , Hrabinova M , Sorf A , Muckova L , Fibigar J , Kucera T , Pulkrabkova L , Jun D , Prchal L , Panek D , Finger V , Soukup O , Cailly T , Collot V , Novakova L , Cahlikova L , Korabecny J |
| Ref : Bioorg Chem , 177 :109894 , 2026 |
| Abstract : |
| PubMedSearch : Al Mamun_2026_Bioorg.Chem_177_109894 |
| PubMedID: 42060983 |