Nitrobenzyl-quinolin-phenylpiperidine-carboxamide-Cpd9i
FAAH IC50 15.8 nM; sEH IC50 36.4 nM; AChE IC50 2.165 microM
General
Type : Nitrobenzyl, Quinoline, Piperidine, Carboxamide, Multitarget, FAAH inhibitor
Chemical_Nomenclature : 1-(4-nitrobenzyl)-N-(4-(quinolin-3-yl)phenyl)piperidine-4-carboxamide
Canonical SMILES : C1=CC(=CC=C1NC(C2CCN(CC2)CC3=CC=C([N+](=O)[O-])C=C3)=O)C5=CC4=CC=CC=C4N=C5
InChI : InChI=1S\/C28H26N4O3\/c33-28(22-13-15-31(16-14-22)19-20-5-11-26(12-6-20)32(34)35)30-25-9-7-21(8-10-25)24-17-23-3-1-2-4-27(23)29-18-24\/h1-12,17-18,22H,13-16,19H2,(H,30,33)
InChIKey : GHQQYCUEKKQGLX-UHFFFAOYSA-N
Other name(s) : Compound 9i
Target
Families : Nitrobenzyl-quinolin-phenylpiperidine-carboxamide-Cpd9i ligand of proteins in family
Epoxide_hydrolase
Protein :
human-EPHX2
References (1)
| Title : Identification of quinolinyl-containing dual soluble epoxide hydrolase\/fatty acid amide hydrolase inhibitors with moderate potency towards acetylcholinesterase - Gonzalez_2026_Results.Chem_23_103159 |
| Author(s) : Gonzalez M , West R , Tsang A , Ocampo O , Hudson PK , Pecic S |
| Ref : Results Chem , 23 : , 2026 |
| Abstract : |
| PubMedSearch : Gonzalez_2026_Results.Chem_23_103159 |
| PubMedID: 41800329 |