OSF
Inhibition of FAAH (fatty acid amide hydrolase (house mouse) not an alpha/beta hydrolase)-mediated [3H]anandamide hydrolysis in mouse brain IC50 0.0019 microM; Inhibition of MAGL-mediated 2-arachidonoylglycerol hydrolysis in mouse brain IC50 0.14 microM
General
Type : Sulfur Compound, NTE inhibitor, Not A\/B H target, Sulfonyl
Chemical_Nomenclature : octane-1-sulfonyl fluoride
Canonical SMILES : CCCCCCCCS(=O)(=O)F
InChI : InChI=1S\/C8H17FO2S\/c1-2-3-4-5-6-7-8-12(9,10)11\/h2-8H2,1H3
InChIKey : HMRWGKIZOBXNRB-UHFFFAOYSA-N
Other name(s) : Octane-1-Sulfonyl Fluoride || CHEMBL499569 || 1-Octanesulfonyl fluoride || 1-Octanesulphonyl fluoride || Octanesulfonyl fluoride
MW : 196.3
Formula : C8H17FO2S
CAS_number : 40630-63-5
PubChem : 162019
UniChem : HMRWGKIZOBXNRB-UHFFFAOYSA-N
Target
Families : OSF ligand of proteins in family
Monoglyceridelipase_lysophospholip
Protein :
mouse-MGLL
References (2)
| Title : Monoacylglycerol lipase regulates 2-arachidonoylglycerol action and arachidonic acid levels - Nomura_2008_Bioorg.Med.Chem.Lett_18_5875 |
| Author(s) : Nomura DK , Hudak CS , Ward AM , Burston JJ , Issa RS , Fisher KJ , Abood ME , Wiley JL , Lichtman AH , Casida JE |
| Ref : Bioorganic & Medicinal Chemistry Lett , 18 :5875 , 2008 |
| Abstract : |
| PubMedSearch : Nomura_2008_Bioorg.Med.Chem.Lett_18_5875 |
| PubMedID: 18752948 |
| Title : Subacute neurotoxicity induced in mice by potent organophosphorus neuropathy target esterase inhibitors - Wu_1996_Toxicol.Appl.Pharmacol_139_195 |
| Author(s) : Wu SY , Casida JE |
| Ref : Toxicology & Applied Pharmacology , 139 :195 , 1996 |
| Abstract : |
| PubMedSearch : Wu_1996_Toxicol.Appl.Pharmacol_139_195 |
| PubMedID: 8685903 |