mouse-MGLL

Mus musculus (Mouse) monoglyceride lipase (EC 3.1.1.23)

Comment

Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes the endocannabinoid 2-arachidonoylglycerol, and thereby contributes to the regulation of endocannabinoid signaling, nociperception and perception of pain. Regulates the levels of fatty acids that serve as signaling molecules and promote cancer cell migration, invasion and tumor growth || Q3UFN1 alternative splicing

Relationship

Family : Monoglyceridelipase_lysophospholip

Block : X

Position in NCBI Life Tree : Mus musculus

(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)

> cellular organisms N E > Eukaryota N E > Opisthokonta N E > Metazoa N E > Eumetazoa N E > Bilateria N E > Deuterostomia N E > Chordata N E > Craniata N E > Vertebrata N E > Gnathostomata N E > Teleostomi N E > Euteleostomi N E > Sarcopterygii N E > Dipnotetrapodomorpha N E > Tetrapoda N E > Amniota N E > Mammalia N E > Theria N E > Eutheria N E > Boreoeutheria N E > Euarchontoglires N E > Glires N E > Rodentia N E > Myomorpha N E > Muroidea N E > Muridae N E > Murinae N E > Mus [genus] N E > Mus [subgenus] N E > Mus musculus N E

Molecular evidence

No mutation

No structure

No kinetic

No disease

No substrate

Sequence

Peptide

MPEASSPRRT PQNVPYQDLP HLVNADGQYL FCRYWKPSGT PKALIFVSHG AGEHCGRYDE LAHMLKGLDM LVFAHDHVGH GQSEGERMVV SDFQVFVRDV LQHVDTIQKD YPDVPIFLLG HSMGGAISIL VAAERPTYFS GMVLISPLVL ANPESASTLK VLAAKLLNFV LPNMTLGRID SSVLSRNKSE VDLYNSDPLV CRAGLKVCFG IQLLNAVARV ERAMPRLTLP FLLLQGSADR LCDSKGAYLL MESSRSQDKT LKMYEGAYHV LHRELPEVTN SVLHEVNSWV SHRIAAAGAG CPP

References (14)

Title : MAGL protects against renal fibrosis through inhibiting tubular cell lipotoxicity - Zhou_2024_Theranostics_14_1583
Author(s) : Zhou S , Ling X , Zhu J , Liang Y , Feng Q , Xie C , Li J , Chen Q , Chen S , Miao J , Zhang M , Li Z , Shen W , Li X , Wu Q , Wang X , Liu R , Wang C , Hou FF , Kong Y , Liu Y , Zhou L
Ref : Theranostics , 14 :1583 , 2024
PubMedID: 38389852
Gene_locus related to this paper: human-MGLL , mouse-MGLL

Title : Monoglyceride Lipase Deficiency Is Associated with Altered Thrombogenesis in Mice - Goeritzer_2023_Int.J.Mol.Sci_24_
Author(s) : Goeritzer M , Kuentzel KB , Beck S , Korbelius M , Rainer S , Bradic I , Kolb D , Mussbacher M , Schrottmaier WC , Assinger A , Schlagenhauf A , Rost R , Gottschalk B , Eichmann TO , Zullig T , Graier WF , Vujic N , Kratky D
Ref : Int J Mol Sci , 24 : , 2023
PubMedID: 36834530
Gene_locus related to this paper: human-MGLL , mouse-MGLL

Title : Multi-parameter optimization: Development of a morpholin-3-one derivative with an improved kinetic profile for imaging monoacylglycerol lipase in the brain - He_2022_Eur.J.Med.Chem_243_114750
Author(s) : He Y , Grether U , Taddio MF , Meier C , Keller C , Edelmann MR , Honer M , Huber S , Wittwer MB , Heer D , Richter H , Collin L , Hug MN , Hilbert M , Postmus AGJ , Stevens AF , van der Stelt M , Kramer SD , Schibli R , Mu L , Gobbi LC
Ref : Eur Journal of Medicinal Chemistry , 243 :114750 , 2022
PubMedID: 36137365
Gene_locus related to this paper: human-MGLL , mouse-MGLL

Title : Termination of acute stress response by the endocannabinoid system is regulated through LSD1-mediated transcriptional repression of 2-AG hydrolases ABHD6 and MAGL - Longaretti_2020_J.Neurochem__e15000
Author(s) : Longaretti A , Forastieri C , Gabaglio M , Rubino T , Battaglioli E , Rusconi F
Ref : Journal of Neurochemistry , :e15000 , 2020
PubMedID: 32141088
Gene_locus related to this paper: human-ABHD6 , human-MGLL , mouse-ABHD6 , mouse-MGLL

Title : Mgll Knockout Mouse Resistance to Diet-Induced Dysmetabolism Is Associated with Altered Gut Microbiota - Dione_2020_Cells_9_
Author(s) : Dione N , Lacroix S , Taschler U , Deschenes T , Abolghasemi A , Leblanc N , Di Marzo V , Silvestri C
Ref : Cells , 9 : , 2020
PubMedID: 33348740
Gene_locus related to this paper: mouse-MGLL

Title : Inhibition of monoacylglycerol lipase reduces nicotine reward in the conditioned place preference test in male mice - Muldoon_2020_Neuropharmacol__108170
Author(s) : Muldoon PP , Akinola LS , Schlosburg JE , Lichtman AH , Sim-Selley LJ , Mahadevan A , Cravatt BF , Damaj MI
Ref : Neuropharmacology , :108170 , 2020
PubMedID: 32479813
Gene_locus related to this paper: human-MGLL , mouse-MGLL

Title : Alterations of endocannabinoid signaling, synaptic plasticity, learning, and memory in monoacylglycerol lipase knock-out mice - Pan_2011_J.Neurosci_31_13420
Author(s) : Pan B , Wang W , Zhong P , Blankman JL , Cravatt BF , Liu QS
Ref : Journal of Neuroscience , 31 :13420 , 2011
PubMedID: 21940435
Gene_locus related to this paper: human-MGLL , mouse-MGLL

Title : Genetic deletion of monoacylglycerol lipase alters endocannabinoid-mediated retrograde synaptic depression in the cerebellum - Zhong_2011_J.Physiol_589_4847
Author(s) : Zhong P , Pan B , Gao XP , Blankman JL , Cravatt BF , Liu QS
Ref : Journal de Physiologie , 589 :4847 , 2011
PubMedID: 21911610
Gene_locus related to this paper: human-MGLL , mouse-MGLL

Title : Identification of Yju3p as functional orthologue of mammalian monoglyceride lipase in the yeast Saccharomycescerevisiae - Heier_2010_Biochim.Biophys.Acta_1801_1063
Author(s) : Heier C , Taschler U , Rengachari S , Oberer M , Wolinski H , Natter K , Kohlwein SD , Leber R , Zimmermann R
Ref : Biochimica & Biophysica Acta , 1801 :1063 , 2010
PubMedID: 20554061
Gene_locus related to this paper: human-MGLL , mouse-MGLL , yeast-mgll

Title : Monoacylglycerol lipase regulates a fatty acid network that promotes cancer pathogenesis - Nomura_2010_Cell_140_49
Author(s) : Nomura DK , Long JZ , Niessen S , Hoover HS , Ng SW , Cravatt BF
Ref : Cell , 140 :49 , 2010
PubMedID: 20079333
Gene_locus related to this paper: human-MGLL , mouse-MGLL

Title : Hydrolysis of prostaglandin glycerol esters by the endocannabinoid-hydrolyzing enzymes, monoacylglycerol lipase and fatty acid amide hydrolase - Vila_2007_Biochemistry_46_9578
Author(s) : Vila A , Rosengarth A , Piomelli D , Cravatt B , Marnett LJ
Ref : Biochemistry , 46 :9578 , 2007
PubMedID: 17649977
Gene_locus related to this paper: human-MGLL , mouse-MGLL

Title : Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs - Okazaki_2002_Nature_420_563
Author(s) : Okazaki Y , Furuno M , Kasukawa T , Adachi J , Bono H , Kondo S , Nikaido I , Osato N , Saito R , Suzuki H , Yamanaka I , Kiyosawa H , Yagi K , Tomaru Y , Hasegawa Y , Nogami A , Schonbach C , Gojobori T , Baldarelli R , Hill DP , Bult C , Hume DA , Quackenbush J , Schriml LM , Kanapin A , Matsuda H , Batalov S , Beisel KW , Blake JA , Bradt D , Brusic V , Chothia C , Corbani LE , Cousins S , Dalla E , Dragani TA , Fletcher CF , Forrest A , Frazer KS , Gaasterland T , Gariboldi M , Gissi C , Godzik A , Gough J , Grimmond S , Gustincich S , Hirokawa N , Jackson IJ , Jarvis ED , Kanai A , Kawaji H , Kawasawa Y , Kedzierski RM , King BL , Konagaya A , Kurochkin IV , Lee Y , Lenhard B , Lyons PA , Maglott DR , Maltais L , Marchionni L , McKenzie L , Miki H , Nagashima T , Numata K , Okido T , Pavan WJ , Pertea G , Pesole G , Petrovsky N , Pillai R , Pontius JU , Qi D , Ramachandran S , Ravasi T , Reed JC , Reed DJ , Reid J , Ring BZ , Ringwald M , Sandelin A , Schneider C , Semple CA , Setou M , Shimada K , Sultana R , Takenaka Y , Taylor MS , Teasdale RD , Tomita M , Verardo R , Wagner L , Wahlestedt C , Wang Y , Watanabe Y , Wells C , Wilming LG , Wynshaw-Boris A , Yanagisawa M , Yang I , Yang L , Yuan Z , Zavolan M , Zhu Y , Zimmer A , Carninci P , Hayatsu N , Hirozane-Kishikawa T , Konno H , Nakamura M , Sakazume N , Sato K , Shiraki T , Waki K , Kawai J , Aizawa K , Arakawa T , Fukuda S , Hara A , Hashizume W , Imotani K , Ishii Y , Itoh M , Kagawa I , Miyazaki A , Sakai K , Sasaki D , Shibata K , Shinagawa A , Yasunishi A , Yoshino M , Waterston R , Lander ES , Rogers J , Birney E , Hayashizaki Y
Ref : Nature , 420 :563 , 2002
PubMedID: 12466851
Gene_locus related to this paper: mouse-1lipg , mouse-1llip , mouse-1plrp , mouse-3neur , mouse-ABH15 , mouse-abhd4 , mouse-abhd5 , mouse-Abhd8 , mouse-Abhd11 , mouse-abhda , mouse-acot4 , mouse-adcl4 , mouse-AI607300 , mouse-BAAT , mouse-bphl , mouse-C87498 , mouse-Ldah , mouse-Ces1d , mouse-Ces2e , mouse-CMBL , mouse-DGLB , mouse-dpp9 , mouse-ES10 , mouse-F135A , mouse-FASN , mouse-hslip , mouse-hyes , mouse-Kansl3 , mouse-LIPH , mouse-LIPK , mouse-lipli , mouse-LIPM , mouse-lypla1 , mouse-lypla2 , mouse-MEST , mouse-MGLL , mouse-ndr4 , mouse-OVCA2 , mouse-pafa , mouse-pcp , mouse-ppce , mouse-Ppgb , mouse-PPME1 , mouse-q3uuq7 , mouse-Q8BLF1 , mouse-ACOT6 , mouse-Q8C1A9 , mouse-Q9DAI6 , mouse-Q80UX8 , mouse-Q8BGG9 , mouse-Q8C167 , mouse-rbbp9 , mouse-SERHL , mouse-tssp

Title : Exon-intron organization and chromosomal localization of the mouse monoglyceride lipase gene - Karlsson_2001_Gene_272_11
Author(s) : Karlsson M , Reue K , Xia YR , Lusis AJ , Langin D , Tornqvist H , Holm C
Ref : Gene , 272 :11 , 2001
PubMedID: 11470505
Gene_locus related to this paper: human-MGLL , mouse-MGLL

Title : cDNA cloning, tissue distribution, and identification of the catalytic triad of monoglyceride lipase. Evolutionary relationship to esterases, lysophospholipases, and haloperoxidases - Karlsson_1997_J.Biol.Chem_272_27218
Author(s) : Karlsson M , Contreras JA , Hellman U , Tornqvist H , Holm C
Ref : Journal of Biological Chemistry , 272 :27218 , 1997
PubMedID: 9341166
Gene_locus related to this paper: mouse-MGLL , ratno-MGLL