Mus musculus (Mouse) monoglyceride lipase (EC 3.1.1.23)
Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes the endocannabinoid 2-arachidonoylglycerol, and thereby contributes to the regulation of endocannabinoid signaling, nociperception and perception of pain. Regulates the levels of fatty acids that serve as signaling molecules and promote cancer cell migration, invasion and tumor growth || Q3UFN1 alternative splicing
Family : Monoglyceridelipase_lysophospholip
Block : X
Position in NCBI Life Tree : Mus musculus
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)
> cellular organisms N E > Eukaryota N E > Opisthokonta N E > Metazoa N E > Eumetazoa N E > Bilateria N E > Deuterostomia N E > Chordata N E > Craniata N E > Vertebrata N E > Gnathostomata N E > Teleostomi N E > Euteleostomi N E > Sarcopterygii N E > Dipnotetrapodomorpha N E > Tetrapoda N E > Amniota N E > Mammalia N E > Theria N E > Eutheria N E > Boreoeutheria N E > Euarchontoglires N E > Glires N E > Rodentia N E > Myomorpha N E > Muroidea N E > Muridae N E > Murinae N E > Mus [genus] N E > Mus [subgenus] N E > Mus musculus N EMPEASSPRRT PQNVPYQDLP HLVNADGQYL FCRYWKPSGT PKALIFVSHG AGEHCGRYDE LAHMLKGLDM LVFAHDHVGH GQSEGERMVV SDFQVFVRDV LQHVDTIQKD YPDVPIFLLG HSMGGAISIL VAAERPTYFS GMVLISPLVL ANPESASTLK VLAAKLLNFV LPNMTLGRID SSVLSRNKSE VDLYNSDPLV CRAGLKVCFG IQLLNAVARV ERAMPRLTLP FLLLQGSADR LCDSKGAYLL MESSRSQDKT LKMYEGAYHV LHRELPEVTN SVLHEVNSWV SHRIAAAGAG CPP
| Title : MAGL protects against renal fibrosis through inhibiting tubular cell lipotoxicity - Zhou_2024_Theranostics_14_1583 |
| Author(s) : Zhou S , Ling X , Zhu J , Liang Y , Feng Q , Xie C , Li J , Chen Q , Chen S , Miao J , Zhang M , Li Z , Shen W , Li X , Wu Q , Wang X , Liu R , Wang C , Hou FF , Kong Y , Liu Y , Zhou L |
| Ref : Theranostics , 14 :1583 , 2024 |
| Abstract : |
| PubMedSearch : Zhou_2024_Theranostics_14_1583 |
| PubMedID: 38389852 |
| Gene_locus related to this paper: human-MGLL , mouse-MGLL |
| Title : Monoglyceride Lipase Deficiency Is Associated with Altered Thrombogenesis in Mice - Goeritzer_2023_Int.J.Mol.Sci_24_ |
| Author(s) : Goeritzer M , Kuentzel KB , Beck S , Korbelius M , Rainer S , Bradic I , Kolb D , Mussbacher M , Schrottmaier WC , Assinger A , Schlagenhauf A , Rost R , Gottschalk B , Eichmann TO , Zullig T , Graier WF , Vujic N , Kratky D |
| Ref : Int J Mol Sci , 24 : , 2023 |
| Abstract : |
| PubMedSearch : Goeritzer_2023_Int.J.Mol.Sci_24_ |
| PubMedID: 36834530 |
| Gene_locus related to this paper: human-MGLL , mouse-MGLL |
| Title : Multi-parameter optimization: Development of a morpholin-3-one derivative with an improved kinetic profile for imaging monoacylglycerol lipase in the brain - He_2022_Eur.J.Med.Chem_243_114750 |
| Author(s) : He Y , Grether U , Taddio MF , Meier C , Keller C , Edelmann MR , Honer M , Huber S , Wittwer MB , Heer D , Richter H , Collin L , Hug MN , Hilbert M , Postmus AGJ , Stevens AF , van der Stelt M , Kramer SD , Schibli R , Mu L , Gobbi LC |
| Ref : Eur Journal of Medicinal Chemistry , 243 :114750 , 2022 |
| Abstract : |
| PubMedSearch : He_2022_Eur.J.Med.Chem_243_114750 |
| PubMedID: 36137365 |
| Gene_locus related to this paper: human-MGLL , mouse-MGLL |
| Title : Inhibition of monoacylglycerol lipase reduces nicotine reward in the conditioned place preference test in male mice - Muldoon_2020_Neuropharmacol__108170 |
| Author(s) : Muldoon PP , Akinola LS , Schlosburg JE , Lichtman AH , Sim-Selley LJ , Mahadevan A , Cravatt BF , Damaj MI |
| Ref : Neuropharmacology , :108170 , 2020 |
| Abstract : |
| PubMedSearch : Muldoon_2020_Neuropharmacol__108170 |
| PubMedID: 32479813 |
| Gene_locus related to this paper: human-MGLL , mouse-MGLL |
| Title : Termination of acute stress response by the endocannabinoid system is regulated through LSD1-mediated transcriptional repression of 2-AG hydrolases ABHD6 and MAGL - Longaretti_2020_J.Neurochem__e15000 |
| Author(s) : Longaretti A , Forastieri C , Gabaglio M , Rubino T , Battaglioli E , Rusconi F |
| Ref : Journal of Neurochemistry , :e15000 , 2020 |
| Abstract : |
| PubMedSearch : Longaretti_2020_J.Neurochem__e15000 |
| PubMedID: 32141088 |
| Gene_locus related to this paper: human-ABHD6 , human-MGLL , mouse-ABHD6 , mouse-MGLL |
| Title : Mgll Knockout Mouse Resistance to Diet-Induced Dysmetabolism Is Associated with Altered Gut Microbiota - Dione_2020_Cells_9_ |
| Author(s) : Dione N , Lacroix S , Taschler U , Deschenes T , Abolghasemi A , Leblanc N , Di Marzo V , Silvestri C |
| Ref : Cells , 9 : , 2020 |
| Abstract : |
| PubMedSearch : Dione_2020_Cells_9_ |
| PubMedID: 33348740 |
| Gene_locus related to this paper: mouse-MGLL |
| Title : Alterations of endocannabinoid signaling, synaptic plasticity, learning, and memory in monoacylglycerol lipase knock-out mice - Pan_2011_J.Neurosci_31_13420 |
| Author(s) : Pan B , Wang W , Zhong P , Blankman JL , Cravatt BF , Liu QS |
| Ref : Journal of Neuroscience , 31 :13420 , 2011 |
| Abstract : |
| PubMedSearch : Pan_2011_J.Neurosci_31_13420 |
| PubMedID: 21940435 |
| Gene_locus related to this paper: human-MGLL , mouse-MGLL |
| Title : Genetic deletion of monoacylglycerol lipase alters endocannabinoid-mediated retrograde synaptic depression in the cerebellum - Zhong_2011_J.Physiol_589_4847 |
| Author(s) : Zhong P , Pan B , Gao XP , Blankman JL , Cravatt BF , Liu QS |
| Ref : Journal de Physiologie , 589 :4847 , 2011 |
| Abstract : |
| PubMedSearch : Zhong_2011_J.Physiol_589_4847 |
| PubMedID: 21911610 |
| Gene_locus related to this paper: human-MGLL , mouse-MGLL |
| Title : Identification of Yju3p as functional orthologue of mammalian monoglyceride lipase in the yeast Saccharomycescerevisiae - Heier_2010_Biochim.Biophys.Acta_1801_1063 |
| Author(s) : Heier C , Taschler U , Rengachari S , Oberer M , Wolinski H , Natter K , Kohlwein SD , Leber R , Zimmermann R |
| Ref : Biochimica & Biophysica Acta , 1801 :1063 , 2010 |
| Abstract : |
| PubMedSearch : Heier_2010_Biochim.Biophys.Acta_1801_1063 |
| PubMedID: 20554061 |
| Gene_locus related to this paper: human-MGLL , mouse-MGLL , yeast-mgll |
| Title : Monoacylglycerol lipase regulates a fatty acid network that promotes cancer pathogenesis - Nomura_2010_Cell_140_49 |
| Author(s) : Nomura DK , Long JZ , Niessen S , Hoover HS , Ng SW , Cravatt BF |
| Ref : Cell , 140 :49 , 2010 |
| Abstract : |
| PubMedSearch : Nomura_2010_Cell_140_49 |
| PubMedID: 20079333 |
| Gene_locus related to this paper: human-MGLL , mouse-MGLL |
| Title : Hydrolysis of prostaglandin glycerol esters by the endocannabinoid-hydrolyzing enzymes, monoacylglycerol lipase and fatty acid amide hydrolase - Vila_2007_Biochemistry_46_9578 |
| Author(s) : Vila A , Rosengarth A , Piomelli D , Cravatt B , Marnett LJ |
| Ref : Biochemistry , 46 :9578 , 2007 |
| Abstract : |
| PubMedSearch : Vila_2007_Biochemistry_46_9578 |
| PubMedID: 17649977 |
| Gene_locus related to this paper: human-MGLL , mouse-MGLL |
| Title : Exon-intron organization and chromosomal localization of the mouse monoglyceride lipase gene - Karlsson_2001_Gene_272_11 |
| Author(s) : Karlsson M , Reue K , Xia YR , Lusis AJ , Langin D , Tornqvist H , Holm C |
| Ref : Gene , 272 :11 , 2001 |
| Abstract : |
| PubMedSearch : Karlsson_2001_Gene_272_11 |
| PubMedID: 11470505 |
| Gene_locus related to this paper: human-MGLL , mouse-MGLL |
| Title : cDNA cloning, tissue distribution, and identification of the catalytic triad of monoglyceride lipase. Evolutionary relationship to esterases, lysophospholipases, and haloperoxidases - Karlsson_1997_J.Biol.Chem_272_27218 |
| Author(s) : Karlsson M , Contreras JA , Hellman U , Tornqvist H , Holm C |
| Ref : Journal of Biological Chemistry , 272 :27218 , 1997 |
| Abstract : |
| PubMedSearch : Karlsson_1997_J.Biol.Chem_272_27218 |
| PubMedID: 9341166 |
| Gene_locus related to this paper: mouse-MGLL , ratno-MGLL |