Oxadiazol-one-piperazine-urea-cpd19
sEH human-EPHX2 IC50 42 nM. Derived from a dual microsomal prostaglandin E2 synthase-1 (mPGES-1)/soluble epoxide hydrolase (sEH) inhibitor but now specific forsEH
General
Type : Oxadiazol, Piperazine, Urea derivative
Chemical_Nomenclature :
Canonical SMILES : C1=C(C=CC(=C1)CNC(N2CCN(CC2)C3=CC=CC=C3Cl)=O)C4=NNC(O4)=O
InChI : 1S\/C20H20ClN5O3\/c21-16-3-1-2-4-17(16)25-9-11-26(12-10-25)19(27)22-13-14-5-7-15(8-6-14)18-23-24-20(28)29-18\/h1-8H,9-13H2,(H,22,27)(H,24,28)
InChIKey : ZOGHSOBGLUHGPO-UHFFFAOYSA-N
Other name(s) : Compound 19
Target
Families : Oxadiazol-one-piperazine-urea-cpd19 ligand of proteins in family
Epoxide_hydrolase
Protein :
human-EPHX2
References (1)
| Title : Discovery and optimization of piperazine urea derivatives as soluble epoxide hydrolase (sEH) inhibitors - Capan_2022_ChemMedChem__ |
| Author(s) : Capan I , Jordan PM , Olgac A , Caliskan B , Kretzer C , Werz O , Banoglu E |
| Ref : ChemMedChem , : , 2022 |
| Abstract : |
| PubMedSearch : Capan_2022_ChemMedChem__ |
| PubMedID: 35466565 |