Periciazine
Periciazine is a phenothiazine of the piperidine group. It has been shown to reduce pathologic arousal and affective tension in some psychotic patients, while the symptoms of abnormal mental integration are relatively unaffected. It is a sedative phenothiazine with weak antipsychotic properties. It also has adrenolytic, anticholinergic, metabolic and endocrine effects and an action on the extrapyramidal system. It is used as an adjunctive medication in some psychotic patients, for the control of residual prevailing hostility, impulsiveness and aggressiveness. eqBChE inhibition (IC50 = 0.23 microM) AChE IC50 7 microM
General
Type : Not A\/B H target, Phenothiazine, Multitarget, Drug, Sulfur Compound, Piperidine, Cyanide
Chemical_Nomenclature : 10-[3-(4-hydroxypiperidin-1-yl)propyl]phenothiazine-2-carbonitrile
Canonical SMILES : C1CN(CCC1O)CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)C#N
InChI : InChI=1S\/C21H23N3OS\/c22-15-16-6-7-21-19(14-16)24(18-4-1-2-5-20(18)26-21)11-3-10-23-12-8-17(25)9-13-23\/h1-2,4-7,14,17,25H,3,8-13H2
InChIKey : LUALIOATIOESLM-UHFFFAOYSA-N
Other name(s) : Propericiazine || propericyazine || Neuleptil || Piperocyanomazine || Nemactil
MW : 365.5
Formula : C21H23N3OS
CAS_number : 2622-26-6
PubChem : 4747
UniChem : LUALIOATIOESLM-UHFFFAOYSA-N
Target
Families : Periciazine ligand of proteins in family
BCHE
Protein :
human-BCHE
References (1)
| Title : Quinolizidinyl derivatives of bi- and tricyclic systems as potent inhibitors of acetyl- and butyrylcholinesterase with potential in Alzheimer's disease - Tasso_2011_Eur.J.Med.Chem_46_2170 |
| Author(s) : Tasso B , Catto M , Nicolotti O , Novelli F , Tonelli M , Giangreco I , Pisani L , Sparatore A , Boido V , Carotti A , Sparatore F |
| Ref : Eur Journal of Medicinal Chemistry , 46 :2170 , 2011 |
| Abstract : |
| PubMedSearch : Tasso_2011_Eur.J.Med.Chem_46_2170 |
| PubMedID: 21459491 |