RIV-Piperidine-Cpd6a
IC50 eqBChE 0.33microM, eeAChE 22.7% at 12.5 microM
General
Type : Piperidine, Derivative of Rivastigmine, Carbamate
Chemical_Nomenclature : 3-(Piperidine-1-carbonyl)phenyl ethyl(methyl)carbamate
Canonical SMILES : CCN(C(OC1=CC=CC(=C1)C(N2CCCCC2)=O)=O)C
InChI : InChI=1S\/C16H22N2O3\/c1-3-17(2)16(20)21-14-9-7-8-13(12-14)15(19)18-10-5-4-6-11-18\/h7-9,12H,3-6,10-11H2,1-2H3
InChIKey : VFASMOJPGPCAMW-UHFFFAOYSA-N
Other name(s) : Compound 6a
Target
Families : RIV-Piperidine-Cpd6a ligand of proteins in family
BCHE
Protein :
human-BCHE
References (1)
| Title : Development of novel rivastigmine derivatives as selective BuChE inhibitors for the treatment of AD - Li_2025_Bioorg.Chem__108245 |
| Author(s) : Li Y , Zhang Q , Wang X , Liu Z , Chen H , Su Z , Xu Y , Zhang W , Du Y , Tan Z , Huang S , Liu W , Sang Z |
| Ref : Bioorg Chem , :108245 , 2025 |
| Abstract : |
| PubMedSearch : Li_2025_Bioorg.Chem__108245 |
| PubMedID: |