ROS151
Compound 5 (ROS151) was found to be a potent AChE inhibitor, as well as a chelator of Fe3+ and Cu2+. IC50 hAChE 0.014 +/- 0.006 microM; IC50 eqBChE 1.68 +/- 0.40 microM; IC50 hFAAH 8.17 +/- 3.77 microM; hMAO-A n.a; hMAO-B 41 +/- 8 % at 10microM
General
Type : Carbamate, Derivative of Rivastigmine, Stigmine, Multitarget, Metal ion chelator
Chemical_Nomenclature : [3-[[[2-(5-fluoro-2-nitrophenoxy)acetyl]amino]methyl]phenyl] N,N-dimethylcarbamate
Canonical SMILES : CN(C)C(=O)OC1=CC=CC(=C1)CNC(=O)COC2=C(C=CC(=C2)F)[N+](=O)[O-]
InChI : InChI=1S\/C18H18FN3O6\/c1-21(2)18(24)28-14-5-3-4-12(8-14)10-20-17(23)11-27-16-9-13(19)6-7-15(16)22(25)26\/h3-9H,10-11H2,1-2H3,(H,20,23)
InChIKey : GTJHPAUPZZRVPC-UHFFFAOYSA-N
Other name(s) : orb2802520 || T201447 || Compound 5
MW : 391.3
Formula : C18H18FN3O6
CAS_number :
PubChem : 176419318
UniChem : GTJHPAUPZZRVPC-UHFFFAOYSA-N
Target
References (1)
| Title : Rivastigmine structure-based hybrids as potential multi-target anti-Alzheimer's drug candidates - Leuci_2024_Bioorg.Chem_153_107895 |
| Author(s) : Leuci R , Simic S , Carrieri A , Chaves S , La Spada G , Brunetti L , Tortorella P , Loiodice F , Laghezza A , Catto M , Santos MA , Tufarelli V , Wackerlig J , Piemontese L |
| Ref : Bioorg Chem , 153 :107895 , 2024 |
| Abstract : |
| PubMedSearch : Leuci_2024_Bioorg.Chem_153_107895 |
| PubMedID: 39454499 |