Rocuronium
neuromuscular non depolarising blocking drug, aminosteroids related to pancuronium and vecuronium, aminosteroid. Rocuronium has an intermediate duration of action and produces its maximum of effect within 2 minutes. Rocuronium can be rapidly reversed with sugammadex, so this drug combination offers an alternative to suxamethonium. Sugammadex, unlike neostigmine, does not inhibit acetylcholinesterase so cholinergic effects are not produced and co-administration of an antimuscarinic agent (glycopyrronium bromide or atropine) is not needed
General
Type : Neuromuscular Nondepolarizing Agents, Aminosteroid, Drug, Not A\/B H target, Morpholine, Phenanthrene
Chemical_Nomenclature : [(2R,3R,5R,8R,9R,10S,13S,14R,16R,17S) -3-hydroxy-10,13-dimethyl-2-morpholin-4-yl-16- (1-prop-2-enyl-2,3,4,5-tetrahydropyrrol-1-yl) -2,3,4,5,6,7,8,9,11,12,14,15,16,17 -tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl] acetate
Canonical SMILES : CC(=O)OC1C(CC2C1(CCC3C2CCC4C3(CC(C(C4)O)N5CCOCC5)C)C)[N+]6(CCCC6)CC=C
InChI : InChI=1S\/C32H53N2O4\/c1-5-14-34(15-6-7-16-34)28-20-26-24-9-8-23-19-29(36)27(33-12-17-37-18-13-33)21-32(23,4)25(24)10-11-31(26,3)30(28)38-22(2)35\/h5,23-30,36H,1,6-21H2,2-4H3\/q+1\/t23-,24+,25-,26-,27-,28-,29-,30-,31-,32-\/m0\/s1
InChIKey : YXRDKMPIGHSVRX-OOJCLDBCSA-N
Other name(s) : Zemuron || ORG 9426
MW : 529.774
Formula : C32H53N2O4
CAS_number : 119302-91-9
PubChem : 441290
UniChem : YXRDKMPIGHSVRX-OOJCLDBCSA-N
IUPHAR : 4003
Wikipedia : Rocuronium_bromide
Target
References (28)
| Title : Sepsis Strengthens Antagonistic Actions of Neostigmine on Rocuronium in a Rat Model of Cecal Ligation and Puncture - Wu_2016_Chin.Med.J.(Engl)_129_1477 |
| Author(s) : Wu J , Jin T , Wang H , Li ST |
| Ref : Chinese Medical Journal (Engl) , 129 :1477 , 2016 |
| Abstract : |
| PubMedSearch : Wu_2016_Chin.Med.J.(Engl)_129_1477 |
| PubMedID: 27270546 |
| Title : Neuromuscular blocking effect of fluoxetine and its interaction with rocuronium - Patel_2013_Auton.Autacoid.Pharmacol_33_17 |
| Author(s) : Patel JC , Barvaliya MJ , Patel TK , Tripathi CB |
| Ref : Auton Autacoid Pharmacol , 33 :17 , 2013 |
| Abstract : |
| PubMedSearch : Patel_2013_Auton.Autacoid.Pharmacol_33_17 |
| PubMedID: 23461555 |
| Title : Pralidoxime inhibits paraoxon-induced depression of rocuronium-neuromuscular block in a time-dependent fashion - Narimatsu_2012_Am.J.Emerg.Med_30_901 |
| Author(s) : Narimatsu E , Niiya T , Takahashi K , Yamauchi M , Yamakage M |
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| Abstract : |
| PubMedSearch : Narimatsu_2012_Am.J.Emerg.Med_30_901 |
| PubMedID: 21871755 |
| Title : Rocuronium reversed by sugammadex for electroconvulsive therapy in a patient with prolonged duration of action of succinylcholine - |
| Author(s) : Visser WA , Ermens AA , de Boer HD , Van Os E |
| Ref : Anaesthesia & Intensive Care , 39 :1153 , 2011 |
| PubMedID: 22165379 |
| Title : [Effective reversal of muscle relaxation by rocuronium using sugammadex in a patient with myasthenia gravis undergoing laparoscopic cholecystectomy] - Komasawa_2011_Masui_60_476 |
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| Abstract : |
| PubMedSearch : Komasawa_2011_Masui_60_476 |
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| Title : Rocuronium antagonized by sugammadex for series of electroconvulsive therapy (ECT) in a patient with pseudocholinesterase deficiency - Batistaki_2011_J.ECT_27_e47 |
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| Abstract : |
| PubMedSearch : Batistaki_2011_J.ECT_27_e47 |
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| Title : Reversal of profound rocuronium-induced blockade with sugammadex: a randomized comparison with neostigmine - Jones_2008_Anesthesiology_109_816 |
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| Abstract : |
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| Title : Sugammadex reversal of rocuronium-induced neuromuscular blockade: a comparison with neostigmine-glycopyrrolate and edrophonium-atropine - Sacan_2007_Anesth.Analg_104_569 |
| Author(s) : Sacan O , White PF , Tufanogullari B , Klein K |
| Ref : Anesthesia & Analgesia , 104 :569 , 2007 |
| Abstract : |
| PubMedSearch : Sacan_2007_Anesth.Analg_104_569 |
| PubMedID: 17312210 |
| Title : A comparison of intubation conditions and time-course of action with rocuronium and mivacurium for day case anaesthesia - Pendeville_2007_Eur.J.Anaesthesiol_24_546 |
| Author(s) : Pendeville PE , Lois F , Scholtes JL |
| Ref : European Journal of Anaesthesiologyiol , 24 :546 , 2007 |
| Abstract : |
| PubMedSearch : Pendeville_2007_Eur.J.Anaesthesiol_24_546 |
| PubMedID: 17241507 |
| Title : Chemical encapsulation of rocuronium by synthetic cyclodextrin derivatives: reversal of neuromuscular block in anaesthetized Rhesus monkeys - de Boer_2006_Br.J.Anaesth_96_201 |
| Author(s) : de Boer HD , van Egmond J , van de Pol F , Bom A , Booij LH |
| Ref : British Journal of Anaesthesia , 96 :201 , 2006 |
| Abstract : |
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| PubMedID: 16377646 |
| Title : First human exposure of Org 25969, a novel agent to reverse the action of rocuronium bromide - Gijsenbergh_2005_Anesthesiology_103_695 |
| Author(s) : Gijsenbergh F , Ramael S , Houwing N , van Iersel T |
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| Abstract : |
| PubMedSearch : Gijsenbergh_2005_Anesthesiology_103_695 |
| PubMedID: 16192761 |
| Title : Tactile assessment for the reversibility of rocuronium-induced neuromuscular blockade during propofol or sevoflurane anesthesia - Kim_2004_Anesth.Analg_99_1080 |
| Author(s) : Kim KS , Cheong MA , Lee HJ , Lee JM |
| Ref : Anesthesia & Analgesia , 99 :1080 , 2004 |
| Abstract : |
| PubMedSearch : Kim_2004_Anesth.Analg_99_1080 |
| PubMedID: 15385354 |
| Title : Antagonism of cisatracurium and rocuronium block at a tactile train-of-four count of 2: should quantitative assessment of neuromuscular function be mandatory? - Kopman_2004_Anesth.Analg_98_102 |
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| Ref : Anesthesia & Analgesia , 98 :102 , 2004 |
| Abstract : |
| PubMedSearch : Kopman_2004_Anesth.Analg_98_102 |
| PubMedID: 14693596 |
| Title : Presynaptic inhibitory effects of rocuronium and SZ1677 on [3H]acetylcholine release from the mouse hemidiaphragm preparation - Takagi_2002_Neurochem.Int_40_655 |
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| Abstract : |
| PubMedSearch : Takagi_2002_Neurochem.Int_40_655 |
| PubMedID: 11900861 |
| Title : Cyclodextrin-derived host molecules as reversal agents for the neuromuscular blocker rocuronium bromide: synthesis and structure-activity relationships - Adam_2002_J.Med.Chem_45_1806 |
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| Ref : Journal of Medicinal Chemistry , 45 :1806 , 2002 |
| Abstract : |
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| Title : Pharmacokinetic\/pharmacodynamic modeling of rocuronium in myasthenic patients is improved by taking into account the number of unbound acetylcholine receptors - De Haes_2002_Anesth.Analg_95_588 |
| Author(s) : De Haes A , Proost JH , Kuks JB , van den Tol DC , Wierda JM |
| Ref : Anesthesia & Analgesia , 95 :588 , 2002 |
| Abstract : |
| PubMedSearch : De Haes_2002_Anesth.Analg_95_588 |
| PubMedID: 12198043 |
| Title : Residual paralysis induced by either vecuronium or rocuronium after reversal with pyridostigmine - Kim_2002_Anesth.Analg_95_1656 |
| Author(s) : Kim KS , Lew SH , Cho HY , Cheong MA |
| Ref : Anesthesia & Analgesia , 95 :1656 , 2002 |
| Abstract : |
| PubMedSearch : Kim_2002_Anesth.Analg_95_1656 |
| PubMedID: 12456433 |
| Title : Clinical pharmacokinetics of the newer neuromuscular blocking drugs - Atherton_1999_Clin.Pharmacokinet_36_169 |
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| Ref : Clinical Pharmacokinetics , 36 :169 , 1999 |
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| PubMedID: 10223167 |
| Title : [Muscle relaxants. New substances and neuromuscular monitoring] - Diefenbach_1997_Anaesthesist_46_3 |
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| Ref : Anaesthesist , 46 :3 , 1997 |
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| PubMedSearch : Diefenbach_1997_Anaesthesist_46_3 |
| PubMedID: 9082865 |
| Title : Failure of neuromuscular blockade reversal after rocuronium in a patient who received oral neomycin - Hasfurther_1996_Can.J.Anaesth_43_617 |
| Author(s) : Hasfurther DL , Bailey PL |
| Ref : Canadian Journal of Anaesthesia , 43 :617 , 1996 |
| Abstract : |
| PubMedSearch : Hasfurther_1996_Can.J.Anaesth_43_617 |
| PubMedID: 8773869 |
| Title : Is recovery of neuromuscular transmission complete after the use of neostigmine to antagonize block produced by rocuronium, vecuronium, atracurium and pancuronium? - Baurain_1996_Br.J.Anaesth_77_496 |
| Author(s) : Baurain MJ , Hoton F , d'Hollander AA , Cantraine FR |
| Ref : British Journal of Anaesthesia , 77 :496 , 1996 |
| Abstract : |
| PubMedSearch : Baurain_1996_Br.J.Anaesth_77_496 |
| PubMedID: 8942335 |
| Title : Dose-response relationships for neostigmine antagonism of rocuronium-induced neuromuscular block in children and adults - Abdulatif_1996_Br.J.Anaesth_77_710 |
| Author(s) : Abdulatif M , Mowafi H , Al-Ghamdi A , el-Sanabary M |
| Ref : British Journal of Anaesthesia , 77 :710 , 1996 |
| Abstract : |
| PubMedSearch : Abdulatif_1996_Br.J.Anaesth_77_710 |
| PubMedID: 9014620 |
| Title : [New muscle relaxants] - Diefenbach_1996_Anasthesiol.Intensivmed.Notfallmed.Schmerzther_31_2 |
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| Ref : Anasthesiol Intensivmed Notfallmed Schmerzther , 31 :2 , 1996 |
| Abstract : |
| PubMedSearch : Diefenbach_1996_Anasthesiol.Intensivmed.Notfallmed.Schmerzther_31_2 |
| PubMedID: 8868525 |
| Title : New neuromuscular blocking drugs [see comments] - Hunter_1995_N.Engl.J.Med_332_1691 |
| Author(s) : Hunter JM |
| Ref : N Engl J Med , 332 :1691 , 1995 |
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| PubMedSearch : Hunter_1995_N.Engl.J.Med_332_1691 |
| PubMedID: 7760871 |
| Title : Dose-response, time-course of action and recovery of rocuronium bromide in children during halothane anaesthesia - Motsch_1995_Eur.J.Anaesthesiol.Supp_11_73 |
| Author(s) : Motsch J , Leuwer M , Bottiger BW , Bach A , Schonstedt R , Martin E |
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| Abstract : |
| PubMedSearch : Motsch_1995_Eur.J.Anaesthesiol.Supp_11_73 |
| PubMedID: 8557011 |
| Title : Newer neuromuscular blocking agents - Bevan_1994_Pharmacol.Toxicol_74_3 |
| Author(s) : Bevan DR |
| Ref : Pharmacol Toxicol , 74 :3 , 1994 |
| Abstract : |
| PubMedSearch : Bevan_1994_Pharmacol.Toxicol_74_3 |
| PubMedID: 8159634 |
| Title : An overview of the pharmacology of rocuronium bromide in experimental animals - Marshall_1994_Eur.J.Anaesthesiol.Supp_9_9 |
| Author(s) : Marshall RJ , Muir AW , Sleigh T , Savage DS |
| Ref : European Journal of Anaesthesiology Supplement , 9 :9 , 1994 |
| Abstract : |
| PubMedSearch : Marshall_1994_Eur.J.Anaesthesiol.Supp_9_9 |
| PubMedID: 7925216 |