SCHEMBL19421119
General
Chemical_Nomenclature : 2-[3-[(3-chloro-4-methylphenyl)methoxy]azetidine-1-carbonyl]-7-oxa-5-azaspiro[3.4]octan-6-one
Canonical SMILES : CC1=C(C=C(C=C1)COC2CN(C2)C(=O)C3CC4(C3)COC(=O)N4)Cl
InChI : InChI=1S\/C18H21ClN2O4\/c1-11-2-3-12(4-15(11)19)9-24-14-7-21(8-14)16(22)13-5-18(6-13)10-25-17(23)20-18\/h2-4,13-14H,5-10H2,1H3,(H,20,23)
InChIKey : AKBHYCHPWZPGAH-UHFFFAOYSA-N
Other name(s) : Magl-IN-4 || Compound 4f || SCHEMBL19409503 || SCHEMBL19409505 || CHEMBL4873898 || SCHEMBL19421119 || 2135785-20-3
MW : 364.8
Formula : C18H21ClN2O4
CAS_number :
PubChem : 130475870
UniChem : AKBHYCHPWZPGAH-UHFFFAOYSA-N
Target
Families : SCHEMBL19421119 ligand of proteins in family
Monoglyceridelipase_lysophospholip
Structure :
7L50
Protein :
human-MGLL
References (2)
| Title : Compound 4f, a novel brain-penetrant reversible monoacylglycerol inhibitor, ameliorates neuroinflammation, neuronal cell loss, and cognitive impairment in mice with kainic acid-induced neurodegeneration - Arimura_2024_PLoS.One_19_e0312090 |
| Author(s) : Arimura N , Maeda C , Aoyama K , Yamaguchi N , Sugiura A , Takahashi Y , Maeda R , Ando T , Kamata M , Matsui H , Tanaka M |
| Ref : PLoS ONE , 19 :e0312090 , 2024 |
| Abstract : |
| PubMedSearch : Arimura_2024_PLoS.One_19_e0312090 |
| PubMedID: 39570850 |
| Gene_locus related to this paper: human-MGLL |
| Title : Design and Synthesis of Novel Spiro Derivatives as Potent and Reversible Monoacylglycerol Lipase (MAGL) Inhibitors: Bioisosteric Transformation from 3-Oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl Moiety - Ikeda_2021_J.Med.Chem__ |
| Author(s) : Ikeda S , Sugiyama H , Tokuhara H , Murakami M , Nakamura M , Oguro Y , Aida J , Morishita N , Sogabe S , Dougan DR , Gay SC , Qin L , Arimura N , Takahashi Y , Sasaki M , Kamada Y , Aoyama K , Kimoto K , Kamata M |
| Ref : Journal of Medicinal Chemistry , : , 2021 |
| Abstract : |
| PubMedSearch : Ikeda_2021_J.Med.Chem__ |
| PubMedID: 34328319 |
| Gene_locus related to this paper: human-MGLL |