Azaspiro

General

Nitrogen containing spirocycles represent a very important class of building blocks in many natural products and pharmaceutical drugs

Inhibitor	Main targeted enzyme families	Type
Cyclopentyl-pyridyl-benzoxazol-cyclopropyl-triazol-azaspiro-heptan-methanone-Cpd29	Monoglyceridelipase_lysophospholip	Benzoxazol Pyridine Piperazine Triazol Azaspiro Cyclopropyl
MGLL-BODIPY-Cpd5	Monoglyceridelipase_lysophospholip	Azaspiro BODIPY-derivative Boranuidatricyclo Boron compound Triazol Fluorescent Probe
MGLL-BODIPY-Cpd9	Monoglyceridelipase_lysophospholip	Azaspiro BODIPY-derivative Boranuidatricyclo Boron compound Fluorescent Probe
MGLL-IN-Cpd118	Monoglyceridelipase_lysophospholip	Triazol Azaspiro Trifluoro Pyrazole
spiro-b-lactam-pyrroloquinoline-6b	S9N_PPCE_Peptidase_S9	Azaspiro beta-Lactam Pyrrolidine Quinoline Organochlorine
SCHEMBL19582562	ABHD6-Lip	Morpholine Carbamate Trifluoro Azaspiro
CHEMBL3908555	PAF-Acetylhydrolase	Azaspiro
Z3J-Cmpd6-7M7V	Thioesterase	Carboxamide Benzofuran Azaspiro
MAGL-2305	Monoglyceridelipase_lysophospholip	PET probe Piperidine Azaspiro
SCHEMBL19421119	Monoglyceridelipase_lysophospholip	Azaspiro Azetidin Organochlorine
SCHEMBL19421059	Monoglyceridelipase_lysophospholip	Azaspiro Piperidine
LK864	Epoxide_hydrolase	Azaspiro Sulfur Compound Sulfonyl Urea derivative Trifluoro
SCHEMBL31549744	Monoglyceridelipase_lysophospholip	Trifluoro Azaspiro Urea derivative Sulfur compound
Cyclopentyl-pyridyl-benzoxazol-cyclopropyl-triazol-azaspiro-heptan-methanone-Cpd29	Monoglyceridelipase_lysophospholip	Benzoxazol Pyridine Piperazine Triazol Azaspiro Cyclopropyl
MGLL-BODIPY-Cpd5	Monoglyceridelipase_lysophospholip	Azaspiro BODIPY-derivative Boranuidatricyclo Boron compound Triazol Fluorescent Probe
MGLL-BODIPY-Cpd9	Monoglyceridelipase_lysophospholip	Azaspiro BODIPY-derivative Boranuidatricyclo Boron compound Fluorescent Probe
MGLL-IN-Cpd118	Monoglyceridelipase_lysophospholip	Triazol Azaspiro Trifluoro Pyrazole
spiro-b-lactam-pyrroloquinoline-6b	S9N_PPCE_Peptidase_S9	Azaspiro beta-Lactam Pyrrolidine Quinoline Organochlorine
SCHEMBL19582562	ABHD6-Lip	Morpholine Carbamate Trifluoro Azaspiro
CHEMBL3908555	PAF-Acetylhydrolase	Azaspiro
Z3J-Cmpd6-7M7V	Thioesterase	Carboxamide Benzofuran Azaspiro
MAGL-2305	Monoglyceridelipase_lysophospholip	PET probe Piperidine Azaspiro
SCHEMBL19421119	Monoglyceridelipase_lysophospholip	Azaspiro Azetidin Organochlorine
SCHEMBL19421059	Monoglyceridelipase_lysophospholip	Azaspiro Piperidine
LK864	Epoxide_hydrolase	Azaspiro Sulfur compound Sulfonyl Urea derivative Trifluoro
SCHEMBL31549744	Monoglyceridelipase_lysophospholip	Trifluoro Azaspiro Urea derivative Sulfur compound
Cyclopentyl-pyridyl-benzoxazol-cyclopropyl-triazol-azaspiro-heptan-methanone-Cpd29	Monoglyceridelipase_lysophospholip	Benzoxazol Pyridine Piperazine Triazol Azaspiro Cyclopropyl
MGLL-BODIPY-Cpd5	Monoglyceridelipase_lysophospholip	Azaspiro BODIPY-derivative Boranuidatricyclo Boron compound Triazol Fluorescent Probe
MGLL-BODIPY-Cpd9	Monoglyceridelipase_lysophospholip	Azaspiro BODIPY-derivative Boranuidatricyclo Boron compound Fluorescent Probe
MGLL-IN-Cpd118	Monoglyceridelipase_lysophospholip	Triazol Azaspiro Trifluoro Pyrazole
spiro-b-lactam-pyrroloquinoline-6b	S9N_PPCE_Peptidase_S9	Azaspiro beta-Lactam Pyrrolidine Quinoline Organochlorine
SCHEMBL19582562	ABHD6-Lip	Morpholine Carbamate Trifluoro Azaspiro
CHEMBL3908555	PAF-Acetylhydrolase	Azaspiro
Z3J-Cmpd6-7M7V	Thioesterase	Carboxamide Benzofuran Azaspiro
MAGL-2305	Monoglyceridelipase_lysophospholip	PET probe Piperidine Azaspiro
SCHEMBL19421119	Monoglyceridelipase_lysophospholip	Azaspiro Azetidin Organochlorine
SCHEMBL19421059	Monoglyceridelipase_lysophospholip	Azaspiro Piperidine
LK864	Epoxide_hydrolase	Azaspiro Sulfur compound Sulfonyl Urea derivative Trifluoro