SCR-1693
tacripyrine SCR-1693 (mecripyrine)
General
Type : Calcium Channel Antagonist, Derivative of Tacrine, Multitarget, anti-Abeta-aggregation
Chemical_Nomenclature : ethyl 5-amino-4-(2-chlorophenyl)-2,7,7-trimethyl-4,6,8,9-tetrahydro-1H-benzo[b][1,8]naphthyridine-3-carboxylate
Canonical SMILES : CCOC(=O)C1=C(NC2=NC3=C(CC(CC3)(C)C)C(=C2C1C4=CC=CC=C4Cl)N)C
InChI : InChI=1S\/C24H28ClN3O2\/c1-5-30-23(29)18-13(2)27-22-20(19(18)14-8-6-7-9-16(14)25)21(26)15-12-24(3,4)11-10-17(15)28-22\/h6-9,19H,5,10-12H2,1-4H3,(H3,26,27,28)
InChIKey : JNWBZVZXAXDSGQ-UHFFFAOYSA-N
Other name(s) : SCHEMBL15026433 || SCR1693 || GLXC-15752 || Mecripyrine || 5-Amino-4-(2-chlorophenyl)-1,4,6,7,8,9-hexahydro-2,7,7-trimethyl-benzo[b][1,8]naphthyridine-3-carboxylic acid ethyl ester
MW : 425.9
Formula : C24H28ClN3O2
CAS_number : 1442559-20-7
PubChem : 71585937
UniChem : JNWBZVZXAXDSGQ-UHFFFAOYSA-N
Target
Families : SCR-1693 ligand of proteins in family
ACHE
Protein :
human-ACHE
References (6)
| Title : SCR-1693 inhibits tau phosphorylation and improves insulin resistance associated cognitive deficits - Bi_2020_Neuropharmacol_168_108027 |
| Author(s) : Bi A , An W , Wang C , Hua Y , Fang F , Dong X , Chen R , Zhang Z , Luo L |
| Ref : Neuropharmacology , 168 :108027 , 2020 |
| Abstract : |
| PubMedSearch : Bi_2020_Neuropharmacol_168_108027 |
| PubMedID: 32145241 |
| Title : Tacrines as Therapeutic Agents for Alzheimer's Disease. IV. The Tacripyrines and Related Annulated Tacrines - Bartolini_2019_Chem.Rec_19_927 |
| Author(s) : Bartolini M , Marco-Contelles J |
| Ref : Chem Rec , 19 :927 , 2019 |
| Abstract : |
| PubMedSearch : Bartolini_2019_Chem.Rec_19_927 |
| PubMedID: 30489012 |
| Title : A novel acetylcholinesterase inhibitor and calcium channel blocker SCR-1693 improves Abeta25-35-impaired mouse cognitive function - Zhang_2016_Psychopharmacology.(Berl)_233_599 |
| Author(s) : Zhang Z , Chen R , An W , Wang C , Liao G , Dong X , Bi A , Yin Z , Luo L |
| Ref : Psychopharmacology (Berl) , 233 :599 , 2016 |
| Abstract : |
| PubMedSearch : Zhang_2016_Psychopharmacology.(Berl)_233_599 |
| PubMedID: 26554390 |
| Title : (-)-SCR1693 Protects against Memory Impairment and Hippocampal Damage in a Chronic Cerebral Hypoperfusion Rat Model - Zhu_2016_Sci.Rep_6_28908 |
| Author(s) : Zhu X , Tian J , Sun S , Dong Q , Zhang F , Zhang X |
| Ref : Sci Rep , 6 :28908 , 2016 |
| Abstract : |
| PubMedSearch : Zhu_2016_Sci.Rep_6_28908 |
| PubMedID: 27349344 |
| Title : A novel tacrine-dihydropyridine hybrid (-)SCR1693 induces tau dephosphorylation and inhibits Abeta generation in cells - Wang_2015_Eur.J.Pharmacol_754_134 |
| Author(s) : Wang XL , Xiong Y , Yang Y , Tuo QZ , Wang XC , Chen R , Tian Q , Zhang ZP , Yan X , Yang ZY , Wang JZ , Liu R |
| Ref : European Journal of Pharmacology , 754 :134 , 2015 |
| Abstract : |
| PubMedSearch : Wang_2015_Eur.J.Pharmacol_754_134 |
| PubMedID: 25732864 |
| Title : Novel Multipotent AChEI-CCB Attenuates Hyperhomocysteinemia-Induced Memory Deficits and Neuropathologies in Rats - Xia_2014_J.Alzheimers.Dis_42_1029 |
| Author(s) : Xia Y , Liu R , Chen R , Tian Q , Zeng K , Hu J , Liu X , Wang Q , Wang P , Wang XC , Wang JZ |
| Ref : J Alzheimers Dis , 42 :1029 , 2014 |
| Abstract : |
| PubMedSearch : Xia_2014_J.Alzheimers.Dis_42_1029 |
| PubMedID: 25024319 |