SP-C01

HsEH IC50(nM)0.03 ; MsEH IC50(nM)1.1

General

Type : Urea derivative, Trifluoro, Multitarget, PPARgamma ligand

Chemical_Nomenclature :

Canonical SMILES : C1(=C(C=C(C=C1)NC(N[C@H]2CC[C@@H](CC2)OC3=CC=C(C=C3)OC(C)=O)=O)F)OC(F)(F)F || SP-C01,CC(OC(C=C1)=CC=C1O[C@H]2CC[C@H](NC(NC3=CC=C(OC(F)(F)F)C(F)=C3)=O)CC2)=O

InChI : InChI=1S\/C22H22F4N2O5\/c1-13(29)31-16-7-9-18(10-8-16)32-17-5-2-14(3-6-17)27-21(30)28-15-4-11-20(19(23)12-15)33-22(24,25)26\/h4,7-12,14,17H,2-3,5-6H2,1H3,(H2,27,28,30)\/t14-,17-

InChIKey : XGMCDWCGZYEFDO-CZIWCDLHSA-N

Other name(s) :


MW : 470.420

Formula : C22H22F4N2O5

CAS_number :

PubChem :

UniChem : XGMCDWCGZYEFDO-CZIWCDLHSA-N

Target

Families : SP-C01 ligand of proteins in family
Epoxide_hydrolase

Protein :
human-EPHX2

References (1)

Title : Structure-Based Design and Optimization Lead to the Identification of a Novel Potent sEH Inhibitor with PPARgamma Partial Agonist Activity against Inflammatory and Metabolic-Related Diseases - Cao_2025_J.Med.Chem__
Author(s) : Cao R , Zhang M , Qi M , Zhang Z , Morisseau C , Zhou C , Sun T , Zhuang J , Chen L , Xu C , Liu Z , Hammock BD , Chen G
Ref : Journal of Medicinal Chemistry , : , 2025
Abstract :
PubMedSearch : Cao_2025_J.Med.Chem__
PubMedID: 40186327