Salithion
Salithion is known to be much more effective than fenitrothion against certain organophosphate (OP)-resistant houseflies
General
Type : Organophosphate, Cyclic OP, Sulfur Compound
Chemical_Nomenclature : 2-methoxy-2-sulfanylidene-4H-1,3,2$l^{5}-benzodioxaphosphinine
Canonical SMILES : COP1(=S)OCC2=CC=CC=C2O1
InChI : InChI=1S\/C8H9O3PS\/c1-9-12(13)10-6-7-4-2-3-5-8(7)11-12\/h2-5H,6H2,1H3
InChIKey : OUNSASXJZHBGAI-UHFFFAOYSA-N
Other name(s) : Dioxabenzofos || Salithion-sumitomo || Dioxabenzophos || Fenphosphorin || 4H-1,3,2-Benzodioxaphosphorin, 2-methoxy-, 2-sulfide || RefChem:588762 || CHEBI:82120 || SCHEMBL83406 || CHEMBL226967
MW : 216.19
Formula : C8H9O3PS
CAS_number : 3811-49-2
PubChem : 19657
UniChem : OUNSASXJZHBGAI-UHFFFAOYSA-N
Target
Families : Salithion ligand of proteins in family
BCHE
ACHE
Protein :
musdo-ACHE
References (24)
| Title : Evaluating the Enantioselective Neurotoxicity of Organophosphorus Pollutant Dioxabenzofos: Mechanistic Studies Employing Cellular, Molecular, and Computational Toxicology Assays - He_2025_ACS.Omega_10_48684 |
| Author(s) : He ZC , Zhang T , Lu XF , Li R , Mei Q , Wang QZ , Ding F , Peng W |
| Ref : ACS Omega , 10 :48684 , 2025 |
| Abstract : |
| PubMedSearch : He_2025_ACS.Omega_10_48684 |
| PubMedID: 41141754 |
| Title : Evaluating the Enantioselective Neurotoxicity of Organophosphorus Pollutant Dioxabenzofos: Mechanistic Studies Employing Cellular, Molecular, and Computational Toxicology Assays - He_2025_ACS.Omega_10_48684 |
| Author(s) : He ZC , Zhang T , Lu XF , Li R , Mei Q , Wang QZ , Ding F , Peng W |
| Ref : ACS Omega , 10 :48684 , 2025 |
| Abstract : |
| PubMedSearch : He_2025_ACS.Omega_10_48684 |
| PubMedID: 41141754 |
| Title : Evaluating the Enantioselective Neurotoxicity of Organophosphorus Pollutant Dioxabenzofos: Mechanistic Studies Employing Cellular, Molecular, and Computational Toxicology Assays - He_2025_ACS.Omega_10_48684 |
| Author(s) : He ZC , Zhang T , Lu XF , Li R , Mei Q , Wang QZ , Ding F , Peng W |
| Ref : ACS Omega , 10 :48684 , 2025 |
| Abstract : |
| PubMedSearch : He_2025_ACS.Omega_10_48684 |
| PubMedID: 41141754 |
| Title : Biologic activity of cyclic and caged phosphates: a review - Lorke_2017_J.Appl.Toxicol_37_13 |
| Author(s) : Lorke DE , Stegmeier-Petroianu A , Petroianu GA |
| Ref : J Appl Toxicol , 37 :13 , 2017 |
| Abstract : |
| PubMedSearch : Lorke_2017_J.Appl.Toxicol_37_13 |
| PubMedID: 27612208 |
| Title : Biologic activity of cyclic and caged phosphates: a review - Lorke_2017_J.Appl.Toxicol_37_13 |
| Author(s) : Lorke DE , Stegmeier-Petroianu A , Petroianu GA |
| Ref : J Appl Toxicol , 37 :13 , 2017 |
| Abstract : |
| PubMedSearch : Lorke_2017_J.Appl.Toxicol_37_13 |
| PubMedID: 27612208 |
| Title : Biologic activity of cyclic and caged phosphates: a review - Lorke_2017_J.Appl.Toxicol_37_13 |
| Author(s) : Lorke DE , Stegmeier-Petroianu A , Petroianu GA |
| Ref : J Appl Toxicol , 37 :13 , 2017 |
| Abstract : |
| PubMedSearch : Lorke_2017_J.Appl.Toxicol_37_13 |
| PubMedID: 27612208 |
| Title : Separation and toxicity of salithion enantiomers - Zhou_2009_Chirality_21_922 |
| Author(s) : Zhou S , Lin K , Li L , Jin M , Ye J , Liu W |
| Ref : Chirality , 21 :922 , 2009 |
| Abstract : |
| PubMedSearch : Zhou_2009_Chirality_21_922 |
| PubMedID: 19161220 |
| Title : Separation and toxicity of salithion enantiomers - Zhou_2009_Chirality_21_922 |
| Author(s) : Zhou S , Lin K , Li L , Jin M , Ye J , Liu W |
| Ref : Chirality , 21 :922 , 2009 |
| Abstract : |
| PubMedSearch : Zhou_2009_Chirality_21_922 |
| PubMedID: 19161220 |
| Title : Separation and toxicity of salithion enantiomers - Zhou_2009_Chirality_21_922 |
| Author(s) : Zhou S , Lin K , Li L , Jin M , Ye J , Liu W |
| Ref : Chirality , 21 :922 , 2009 |
| Abstract : |
| PubMedSearch : Zhou_2009_Chirality_21_922 |
| PubMedID: 19161220 |
| Title : Determination of organophosphorous pesticides in biological samples of acute poisoning by HPLC with diode-array detector - Cho_1997_Chem.Pharm.Bull.(Tokyo)_45_737 |
| Author(s) : Cho Y , Matsuoka N , Kamiya A |
| Ref : Chem Pharm Bull (Tokyo) , 45 :737 , 1997 |
| Abstract : |
| PubMedSearch : Cho_1997_Chem.Pharm.Bull.(Tokyo)_45_737 |
| PubMedID: 9145509 |
| Title : Determination of organophosphorous pesticides in biological samples of acute poisoning by HPLC with diode-array detector - Cho_1997_Chem.Pharm.Bull.(Tokyo)_45_737 |
| Author(s) : Cho Y , Matsuoka N , Kamiya A |
| Ref : Chem Pharm Bull (Tokyo) , 45 :737 , 1997 |
| Abstract : |
| PubMedSearch : Cho_1997_Chem.Pharm.Bull.(Tokyo)_45_737 |
| PubMedID: 9145509 |
| Title : Determination of organophosphorous pesticides in biological samples of acute poisoning by HPLC with diode-array detector - Cho_1997_Chem.Pharm.Bull.(Tokyo)_45_737 |
| Author(s) : Cho Y , Matsuoka N , Kamiya A |
| Ref : Chem Pharm Bull (Tokyo) , 45 :737 , 1997 |
| Abstract : |
| PubMedSearch : Cho_1997_Chem.Pharm.Bull.(Tokyo)_45_737 |
| PubMedID: 9145509 |
| Title : Characteristics of Houseflies Selected by Fenitrothion and Diethyl Fenitrothion - Shiotsuki_1988_Agric.Biol.Chem_52_2191 |
| Author(s) : Shiotsuki T , Takeya R , Eto M , Shono T |
| Ref : Agric and Biological Chemistry , 52 :2191 , 1988 |
| Abstract : |
| PubMedSearch : Shiotsuki_1988_Agric.Biol.Chem_52_2191 |
| PubMedID: |
| Title : Characteristics of Houseflies Selected by Fenitrothion and Diethyl Fenitrothion - Shiotsuki_1988_Agric.Biol.Chem_52_2191 |
| Author(s) : Shiotsuki T , Takeya R , Eto M , Shono T |
| Ref : Agric and Biological Chemistry , 52 :2191 , 1988 |
| Abstract : |
| PubMedSearch : Shiotsuki_1988_Agric.Biol.Chem_52_2191 |
| PubMedID: |
| Title : Characteristics of Houseflies Selected by Fenitrothion and Diethyl Fenitrothion - Shiotsuki_1988_Agric.Biol.Chem_52_2191 |
| Author(s) : Shiotsuki T , Takeya R , Eto M , Shono T |
| Ref : Agric and Biological Chemistry , 52 :2191 , 1988 |
| Abstract : |
| PubMedSearch : Shiotsuki_1988_Agric.Biol.Chem_52_2191 |
| PubMedID: |
| Title : Spontaneous reactivation of mouse plasma cholinesterase after inhibition by various organophosphorus compounds - Matsubara_1984_J.Pharmacobiodyn_7_322 |
| Author(s) : Matsubara T , Horikoshi I |
| Ref : J Pharmacobiodyn , 7 :322 , 1984 |
| Abstract : |
| PubMedSearch : Matsubara_1984_J.Pharmacobiodyn_7_322 |
| PubMedID: 6470929 |
| Title : Spontaneous reactivation of mouse plasma cholinesterase after inhibition by various organophosphorus compounds - Matsubara_1984_J.Pharmacobiodyn_7_322 |
| Author(s) : Matsubara T , Horikoshi I |
| Ref : J Pharmacobiodyn , 7 :322 , 1984 |
| Abstract : |
| PubMedSearch : Matsubara_1984_J.Pharmacobiodyn_7_322 |
| PubMedID: 6470929 |
| Title : Spontaneous reactivation of mouse plasma cholinesterase after inhibition by various organophosphorus compounds - Matsubara_1984_J.Pharmacobiodyn_7_322 |
| Author(s) : Matsubara T , Horikoshi I |
| Ref : J Pharmacobiodyn , 7 :322 , 1984 |
| Abstract : |
| PubMedSearch : Matsubara_1984_J.Pharmacobiodyn_7_322 |
| PubMedID: 6470929 |
| Title : Development of insecticidal cyclic phosphoryl compounds through chemical and biochemical approaches - Eto_1983_J.Environ.Sci.Health.B_18_119 |
| Author(s) : Eto M |
| Ref : J Environ Sci Health B , 18 :119 , 1983 |
| Abstract : |
| PubMedSearch : Eto_1983_J.Environ.Sci.Health.B_18_119 |
| PubMedID: 6339599 |
| Title : Development of insecticidal cyclic phosphoryl compounds through chemical and biochemical approaches - Eto_1983_J.Environ.Sci.Health.B_18_119 |
| Author(s) : Eto M |
| Ref : J Environ Sci Health B , 18 :119 , 1983 |
| Abstract : |
| PubMedSearch : Eto_1983_J.Environ.Sci.Health.B_18_119 |
| PubMedID: 6339599 |
| Title : Development of insecticidal cyclic phosphoryl compounds through chemical and biochemical approaches - Eto_1983_J.Environ.Sci.Health.B_18_119 |
| Author(s) : Eto M |
| Ref : J Environ Sci Health B , 18 :119 , 1983 |
| Abstract : |
| PubMedSearch : Eto_1983_J.Environ.Sci.Health.B_18_119 |
| PubMedID: 6339599 |
| Title : Biochemical interaction of six OP delayed neurotoxicants with several neurotargets - El-Sebae_1981_J.Environ.Sci.Health.B_16_465 |
| Author(s) : El-Sebae AH , Soliman SA , Ahmed NS , Curley A |
| Ref : J Environ Sci Health B , 16 :465 , 1981 |
| Abstract : |
| PubMedSearch : El-Sebae_1981_J.Environ.Sci.Health.B_16_465 |
| PubMedID: 6169754 |
| Title : Biochemical interaction of six OP delayed neurotoxicants with several neurotargets - El-Sebae_1981_J.Environ.Sci.Health.B_16_465 |
| Author(s) : El-Sebae AH , Soliman SA , Ahmed NS , Curley A |
| Ref : J Environ Sci Health B , 16 :465 , 1981 |
| Abstract : |
| PubMedSearch : El-Sebae_1981_J.Environ.Sci.Health.B_16_465 |
| PubMedID: 6169754 |
| Title : Biochemical interaction of six OP delayed neurotoxicants with several neurotargets - El-Sebae_1981_J.Environ.Sci.Health.B_16_465 |
| Author(s) : El-Sebae AH , Soliman SA , Ahmed NS , Curley A |
| Ref : J Environ Sci Health B , 16 :465 , 1981 |
| Abstract : |
| PubMedSearch : El-Sebae_1981_J.Environ.Sci.Health.B_16_465 |
| PubMedID: 6169754 |