Sigma1R-BCHE-Cpd18c
hBCHE IC50 = 3.3 nM (45-fold selectivity over human acetylcholinesterase) and strong S1R agonistic activity (IC50 = 25 nM, EC50 = 99 nM). The cleavage product 14c (after carbamate hydrolysis by hBChE) retained dual activity (IC50(hBChE) = 269 nM, IC50(S1R) = 20 nM, and EC50(S1R) = 279 nM)
General
Type : Multitarget, Sigma1R ligand, Azetidin, Carbamate, Benzylpiperidine
Chemical_Nomenclature : 2-(2-((2-(1-benzylpiperidin-4-yl)ethyl)amino)-2-oxoethyl)phenyl azetidine-1-carboxylate
Canonical SMILES : C1(=CC=CC=C1OC(N2CCC2)=O)CC(NCCC3CCN(CC3)CC4=CC=CC=C4)=O
InChI : InChI=1S\/C26H33N3O3\/c30-25(19-23-9-4-5-10-24(23)32-26(31)29-15-6-16-29)27-14-11-21-12-17-28(18-13-21)20-22-7-2-1-3-8-22\/h1-5,7-10,21H,6,11-20H2,(H,27,30)
InChIKey : YNKDXPGOCHGPPU-UHFFFAOYSA-N
Other name(s) : Compound 18c
Target
Families : Sigma1R-BCHE-Cpd18c ligand of proteins in family
BCHE
Protein :
human-BCHE
References (1)
| Title : A Dual Approach To Combat Alzheimer's Disease through Concomitant hBChE Inhibition and S1R Activation - Reichau_2026_ACS.Chem.Neurosci__ |
| Author(s) : Reichau K , Crouzier L , Poeta E , Gehrig T , Schaller E , Zvejniece L , Meunier J , Sotriffer C , Monti B , Maurice T , Decker M |
| Ref : ACS Chem Neurosci , : , 2026 |
| Abstract : |
| PubMedSearch : Reichau_2026_ACS.Chem.Neurosci__ |
| PubMedID: 41593428 |