TA8Amino
IC50 hACHE 0.014 +/- 0.009; hBCHE 3.69 +/- 0.84
General
Type : Derivative of Tacrine, Derivative of Donepezil, Quinoline, Piperidine, Inden
Chemical_Nomenclature : (2E)-2-[[1-[(4-aminoquinolin-2-yl)methyl]piperidin-4-yl]methylidene]-5,6-dimethoxy-3H-inden-1-one
Canonical SMILES : COC1=C(C=C2C(=C1)C\/C(=CC3CCN(CC3)CC4=NC5=CC=CC=C5C(=C4)N)\/C2=O)OC
InChI : InChI=1S\/C27H29N3O3\/c1-32-25-13-18-12-19(27(31)22(18)15-26(25)33-2)11-17-7-9-30(10-8-17)16-20-14-23(28)21-5-3-4-6-24(21)29-20\/h3-6,11,13-15,17H,7-10,12,16H2,1-2H3,(H2,28,29)\/b19-11+
InChIKey : LCWJAHTZACCSBC-YBFXNURJSA-N
Other name(s) : Compound 14 || CHEMBL4166300 || BDBM50277655
MW : 443.5
Formula : C27H29N3O3
CAS_number :
PubChem : 145952662
UniChem : LCWJAHTZACCSBC-YBFXNURJSA-N
Target
Families : TA8Amino ligand of proteins in family
ACHE
Protein :
human-ACHE
References (3)
| Title : Novel Dual AChE and ROCK2 Inhibitor Induces Neurogenesis via PTEN\/AKT Pathway in Alzheimer's Disease Model - Moreira_2022_Int.J.Mol.Sci_23_14788 |
| Author(s) : Moreira N , Tamarozzi ER , Lima J , Piassi LO , Carvalho I , Passos GA , Sakamoto-Hojo ET |
| Ref : Int J Mol Sci , 23 :14788 , 2022 |
| Abstract : |
| PubMedSearch : Moreira_2022_Int.J.Mol.Sci_23_14788 |
| PubMedID: 36499116 |
| Title : Novel Hybrid Acetylcholinesterase Inhibitors Induce Differentiation and Neuritogenesis in Neuronal Cells in vitro Through Activation of the AKT Pathway - Moreira_2020_J.Alzheimers.Dis_78_353 |
| Author(s) : Moreira N , Lima J , Chierrito TPC , Carvalho I , Sakamoto-Hojo ET |
| Ref : J Alzheimers Dis , 78 :353 , 2020 |
| Abstract : |
| PubMedSearch : Moreira_2020_J.Alzheimers.Dis_78_353 |
| PubMedID: 32986667 |
| Title : From dual binding site acetylcholinesterase inhibitors to allosteric modulators: A new avenue for disease-modifying drugs in Alzheimer's disease - Chierrito_2017_Eur.J.Med.Chem_139_773 |
| Author(s) : Chierrito TPC , Mantoani SP , Roca C , Requena C , Sebastian-Perez V , Castillo WO , Moreira NCS , Perez C , Sakamoto-Hojo ET , Takahashi CS , Jimenez-Barbero J , Canada FJ , Campillo NE , Martinez A , Carvalho I |
| Ref : Eur Journal of Medicinal Chemistry , 139 :773 , 2017 |
| Abstract : |
| PubMedSearch : Chierrito_2017_Eur.J.Med.Chem_139_773 |
| PubMedID: 28863358 |