TPHP

Triphenyl phosphate TPP, Organophosphorus flame retardant. May have adipogenic effects through PPARgamma activation. Triphenyl phosphate permeates the blood brain barrier and induces neurotoxicity in mouse brain. TPP is a widely used synergist, which can reduce the use of pesticides (chemicals or virus) by inhibiting carboxylesterase

General

Type : Organophosphorus flame retardant plasticizer, Organophosphate, Synergist of insecticide

Chemical_Nomenclature :

Canonical SMILES : C1=CC=C(C=C1)OP(=O)(OC2=CC=CC=C2)OC3=CC=CC=C3

InChI : InChI=1S\/C18H15O4P\/c19-23(20-16-10-4-1-5-11-16,21-17-12-6-2-7-13-17)22-18-14-8-3-9-15-18\/h1-15H

InChIKey : XZZNDPSIHUTMOC-UHFFFAOYSA-N

Other name(s) : triphenyl phosphate  ||  TPP  ||  Component of Firemaster 550  ||  (C6H5)3PO4  ||  Triphenylphosphate  ||  Phosphoric acid, triphenyl ester  ||  Disflamoll TP


MW : 326.3

Formula : C18H15O4P

CAS_number : 115-86-6

PubChem : 8289

UniChem : XZZNDPSIHUTMOC-UHFFFAOYSA-N

Target

References (51)

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Title : Linking biochemical and individual-level effects of chlorpyrifos, triphenyl phosphate, and bisphenol A on sea urchin (Paracentrotus lividus) larvae - Bellas_2022_Environ.Sci.Pollut.Res.Int__
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Gene_locus related to this paper: spolt-ACHE1

Title : Recombinant AcMNPV-gp64-EGFP and synergist triphenyl phosphate, an effective combination against Spodoptera frugiperda - Jiao_2022_Biotechnol.Lett__
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Title : Triphenyl phosphate disturbs the lipidome and induces endoplasmic reticulum stress and apoptosis in JEG-3 cells - Wang_2021_Chemosphere_275_129978
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Title : Characterization of the insecticide detoxification carboxylesterase Boest1 from Bradysia odoriphaga Yang et Zhang (Diptera:Sciaridae) - Ding_2021_Pest.Manag.Sci__
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Gene_locus related to this paper: 9dipt-Boest1 , braco-est1

Title : Bioremediation of triphenyl phosphate by Pycnoporus sanguineus: Metabolic pathway, proteomic mechanism and biotoxicity assessment - Feng_2021_J.Hazard.Mater_417_125983
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Title : Two carboxylesterase genes in Plutella xylostella associated with sex pheromones and plant volatiles degradation - Wang_2021_Pest.Manag.Sci__
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PubMedSearch : Wang_2021_Pest.Manag.Sci__
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Gene_locus related to this paper: pluxy-CCE016a , pluxy-CCE016c

Title : In Vitro Metabolism of Isopropylated and tert-Butylated Triarylphosphate Esters Using Human Liver Subcellular Fractions - Phillips_2020_Chem.Res.Toxicol_33_1428
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Title : Organophosphorus flame retardant induced hepatotoxicity and brain AChE inhibition on zebrafish (Danio rerio) - Ramesh_2020_Neurotoxicol.Teratol__106919
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Title : Susceptibility of fall armyworm, Spodoptera frugiperda (J.E.Smmith), to eight insecticides in China, with special reference to lambda-cyhalothrin - Zhao_2020_Pestic.Biochem.Physiol_168_104623
Author(s) : Zhao YX , Huang JM , Ni H , Guo D , Yang FX , Wang X , Wu SF , Gao CF
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Title : Cholinesterase Inhibition and Exposure to Organophosphate Esters in Aircraft Maintenance Workers - Hardos_2020_Aerosp.Med.Hum.Perform_91_710
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Title : Adipogenic activity of 2-ethylhexyl diphenyl phosphate via peroxisome proliferator-activated receptor gamma pathway - Sun_2020_Sci.Total.Environ_711_134810
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Title : Sex- and age-dependent effects of maternal organophosphate flame-retardant exposure on neonatal hypothalamic and hepatic gene expression - Adams_2020_Reprod.Toxicol_94_65
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Title : Triphenyl phosphate permeates the blood brain barrier and induces neurotoxicity in mouse brain - Liu_2020_Chemosphere_252_126470
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PubMedSearch : Liu_2020_Chemosphere_252_126470
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Title : Inhibition of Human Liver Carboxylesterase (hCE1) by Organophosphate Ester Flame Retardants and Plasticizers: Implications for Pharmacotherapy - Phillips_2019_Toxicol.Sci_171_396
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Title : Acute exposure to triphenyl phosphate (TPhP) disturbs ocular development and muscular organization in zebrafish larvae - Shi_2019_Ecotoxicol.Environ.Saf_179_119
Author(s) : Shi Q , Tsui MMP , Hu C , Lam JCW , Zhou B , Chen L
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Title : Effect of Synergists on Deltamethrin Resistance in the Common Bed Bug (Hemiptera: Cimicidae) - Gonzalez-Morales_2019_J.Econ.Entomol_112_786
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Title : Developmental neurotoxicity of triphenyl phosphate in zebrafish larvae - Shi_2018_Aquat.Toxicol_203_80
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PubMedSearch : Shi_2018_Aquat.Toxicol_203_80
PubMedID: 30096480

Title : Di-branched triphenylamine dye sensitized TiO2 nanocomposites with good photo-stability for sensitive photoelectrochemical detection of organophosphate pesticides - Song_2018_Anal.Chim.Acta_1001_24
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Title : Characterization and functional analysis of a carboxylesterase gene associated with chlorpyrifos resistance in Nilaparvata lugens (Stal) - Lu_2017_Comp.Biochem.Physiol.C.Toxicol.Pharmacol_203_12
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PubMedID: 29054582
Gene_locus related to this paper: nillu-NlCarE

Title : Carboxylesterase-involved metabolism of di-n-butyl phthalate in pumpkin (Cucurbita moschata) seedlings - Lin_2017_Environ.Pollut_220_421
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Title : Adipogenic Effects and Gene Expression Profiling of Firemaster 550 Components in Human Primary Preadipocytes - Tung_2017_Environ.Health.Perspect_125_097013
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PubMedSearch : Tung_2017_Environ.Health.Perspect_125_097013
PubMedID: 28934090

Title : Firemaster 550 and its components isopropylated triphenyl phosphate and triphenyl phosphate enhance adipogenesis and transcriptional activity of peroxisome proliferator activated receptor (Ppargamma) on the adipocyte protein 2 (aP2) promoter - Tung_2017_PLoS.One_12_e0175855
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Title : Functional characterization of an alpha-esterase gene involving malathion detoxification in Bactrocera dorsalis (Hendel) - Wang_2016_Pestic.Biochem.Physiol_130_44
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Gene_locus related to this paper: bacdo-a0a034w7m1

Title : Developmental neurotoxicity of organophosphate flame retardants in early life stages of Japanese medaka (Oryzias latipes) - Sun_2016_Environ.Toxicol.Chem_35_2931
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Title : Mechanisms of organophosphate resistance in a field population of oriental migratory locust, Locusta migratoria manilensis (Meyen) - Yang_2009_Arch.Insect.Biochem.Physiol_71_3
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Title : Isolation of an esterase conferring insecticide resistance in the mosquito Culex tarsalis - Whyard_1994_Insect.Biochem.Mol.Biol_24_819
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Gene_locus related to this paper: human-CES1

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Title : Evaluation of cytotoxic responses caused by selected organophosphorus esters in chick sympathetic ganglia cultures - Obersteiner_1978_Can.J.Comp.Med_42_80
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