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Synergist of insecticide

General

Insecticide resistance is frequently linked to metabolic detoxification enzymes such as cytochrome monooxygenase (P450s), esterases, glutathione S-tranferase, and carboxylesterase. To overcome insecticide resistance synergists are added to formulations. These counteract metabolic resistance. Synergists have been used in the laboratory as tools for assessing the significance of various degradation reactions for insecticide toxicity. There are specific inhibitors for oxidative and hydrolytic degradation processes. Few of these compounds are inhibitors of alpha\/beta hydrolases
Inhibitor Main targeted enzyme familyes Type Structure
TPHP Organophosphorus flame retardant plasticizer Organophosphate Synergist of insecticide
Diethyl-maleate Synergist of insecticide Not A\/B H target
Piperonyl-butoxide Benzodioxo Synergist of insecticide Not A\/B H target
Tribufos ACHE BCHE Carb_B_Arthropoda Carb_B_Chordata ACPH_Peptidase_S9 Organophosphate Synergist of insecticide Sulfur Compound