Ticagrelor
Ticagrelor is a triazolopyrimidine that is an adenosine isostere; the cyclopentane ring is similar to ribose and the nitrogen-rich [1,2,3]triazolo[4,5-d]pyrimidine moiety resembles the nucleobase adenine. A platelet aggregation inhibitor which is used for prevention of thromboembolic events in patients with acute coronary syndrome. It has a role as a platelet aggregation inhibitor and a P2Y12 receptor antagonist. Unlike [clopidogrel], ticagrelor is not a prodrug. Pancratic lipase inhibitor
General
Type : Not AlphaBeta Hydrolase target, Drug, Pyrimidine, Triazol, Sulfur Compound, Antiplatelet, Cyclopropyl
Chemical_Nomenclature : (1S,2S,3R,5S)-3-[7-[[(1R,2S)-2-(3,4-difluorophenyl)cyclopropyl]amino]-5-propylsulfanyltriazolo[4,5-d]pyrimidin-3-yl]-5-(2-hydroxyethoxy)cyclopentane-1,2-diol
Canonical SMILES : CCCSC1=NC(=C2C(=N1)N(N=N2)[C@@H]3C[C@@H]([C@H]([C@H]3O)O)OCCO)N[C@@H]4C[C@H]4C5=CC(=C(C=C5)F)F
InChI : InChI=1S\/C23H28F2N6O4S\/c1-2-7-36-23-27-21(26-15-9-12(15)11-3-4-13(24)14(25)8-11)18-22(28-23)31(30-29-18)16-10-17(35-6-5-32)20(34)19(16)33\/h3-4,8,12,15-17,19-20,32-34H,2,5-7,9-10H2,1H3,(H,26,27,28)\/t12-,15+,16+,17-,19-,20+\/m0\/s1
InChIKey : OEKWJQXRCDYSHL-FNOIDJSQSA-N
Other name(s) : Brilinta || Brilique || AZD6140 || Possia || AZD-6140 || AR-C126532XX || HC-14
MW : 522.6
Formula : C23H28F2N6O4S
CAS_number : 274693-27-5
PubChem : 9871419
UniChem : OEKWJQXRCDYSHL-FNOIDJSQSA-N
Target
Families : Ticagrelor ligand of proteins in family
Pancreatic_lipase
Protein :
human-PNLIP
References (9)
| Title : Discovery of hypoglycemic and cardiovascular drugs as the effective inhibitors on human pancreatic lipase - Liang_2025_Chem.Biodivers__e202500381 |
| Author(s) : Liang BJ , Dong LX , Yu Y , Zhang J , Wang DD , He WY , Wang SX , Zou L |
| Ref : Chem Biodivers , :e202500381 , 2025 |
| Abstract : |
| PubMedSearch : Liang_2025_Chem.Biodivers__e202500381 |
| PubMedID: 40264379 |
| Title : Discovery of hypoglycemic and cardiovascular drugs as the effective inhibitors on human pancreatic lipase - Liang_2025_Chem.Biodivers__e202500381 |
| Author(s) : Liang BJ , Dong LX , Yu Y , Zhang J , Wang DD , He WY , Wang SX , Zou L |
| Ref : Chem Biodivers , :e202500381 , 2025 |
| Abstract : |
| PubMedSearch : Liang_2025_Chem.Biodivers__e202500381 |
| PubMedID: 40264379 |
| Title : Discovery of hypoglycemic and cardiovascular drugs as the effective inhibitors on human pancreatic lipase - Liang_2025_Chem.Biodivers__e202500381 |
| Author(s) : Liang BJ , Dong LX , Yu Y , Zhang J , Wang DD , He WY , Wang SX , Zou L |
| Ref : Chem Biodivers , :e202500381 , 2025 |
| Abstract : |
| PubMedSearch : Liang_2025_Chem.Biodivers__e202500381 |
| PubMedID: 40264379 |
| Title : Randomized evaluation of the loss-of-function carboxylesterase 1 (CES1) G143E variant on clopidogrel and ticagrelor pharmacodynamics - Lewis_2024_Clin.Transl.Sci_17_e70079 |
| Author(s) : Lewis JP , Ryan KA , Streeten EA , Whitlatch HB , Daue M , Tanner K , Perry JA , O'Connell JR , Shuldiner AR , Mitchell BD |
| Ref : Clin Transl Sci , 17 :e70079 , 2024 |
| Abstract : |
| PubMedSearch : Lewis_2024_Clin.Transl.Sci_17_e70079 |
| PubMedID: 39576732 |
| Title : Randomized evaluation of the loss-of-function carboxylesterase 1 (CES1) G143E variant on clopidogrel and ticagrelor pharmacodynamics - Lewis_2024_Clin.Transl.Sci_17_e70079 |
| Author(s) : Lewis JP , Ryan KA , Streeten EA , Whitlatch HB , Daue M , Tanner K , Perry JA , O'Connell JR , Shuldiner AR , Mitchell BD |
| Ref : Clin Transl Sci , 17 :e70079 , 2024 |
| Abstract : |
| PubMedSearch : Lewis_2024_Clin.Transl.Sci_17_e70079 |
| PubMedID: 39576732 |
| Title : Randomized evaluation of the loss-of-function carboxylesterase 1 (CES1) G143E variant on clopidogrel and ticagrelor pharmacodynamics - Lewis_2024_Clin.Transl.Sci_17_e70079 |
| Author(s) : Lewis JP , Ryan KA , Streeten EA , Whitlatch HB , Daue M , Tanner K , Perry JA , O'Connell JR , Shuldiner AR , Mitchell BD |
| Ref : Clin Transl Sci , 17 :e70079 , 2024 |
| Abstract : |
| PubMedSearch : Lewis_2024_Clin.Transl.Sci_17_e70079 |
| PubMedID: 39576732 |
| Title : Difference in substrate specificity of carboxylesterase and arylacetamide deacetylase between dogs and humans - Yoshida_2018_Eur.J.Pharm.Sci_111_167 |
| Author(s) : Yoshida T , Fukami T , Kurokawa T , Gotoh S , Oda A , Nakajima M |
| Ref : Eur J Pharm Sci , 111 :167 , 2018 |
| Abstract : |
| PubMedSearch : Yoshida_2018_Eur.J.Pharm.Sci_111_167 |
| PubMedID: 28966098 |
| Gene_locus related to this paper: canfa-CESDD1 , canfa-f1p6w8 , canlf-e2r2h2 |
| Title : Difference in substrate specificity of carboxylesterase and arylacetamide deacetylase between dogs and humans - Yoshida_2018_Eur.J.Pharm.Sci_111_167 |
| Author(s) : Yoshida T , Fukami T , Kurokawa T , Gotoh S , Oda A , Nakajima M |
| Ref : Eur J Pharm Sci , 111 :167 , 2018 |
| Abstract : |
| PubMedSearch : Yoshida_2018_Eur.J.Pharm.Sci_111_167 |
| PubMedID: 28966098 |
| Gene_locus related to this paper: canfa-CESDD1 , canfa-f1p6w8 , canlf-e2r2h2 |
| Title : Difference in substrate specificity of carboxylesterase and arylacetamide deacetylase between dogs and humans - Yoshida_2018_Eur.J.Pharm.Sci_111_167 |
| Author(s) : Yoshida T , Fukami T , Kurokawa T , Gotoh S , Oda A , Nakajima M |
| Ref : Eur J Pharm Sci , 111 :167 , 2018 |
| Abstract : |
| PubMedSearch : Yoshida_2018_Eur.J.Pharm.Sci_111_167 |
| PubMedID: 28966098 |
| Gene_locus related to this paper: canfa-CESDD1 , canfa-f1p6w8 , canlf-e2r2h2 |