Cyclopropane is the cycloalkane with the molecular formula (CH2)3, consisting of three methylene groups (CH2) linked to each other to form a ring. The small size of the ring creates substantial ring strain in the structure. Building block for many inhibitors of enzymes.
Inhibitor Main targeted enzyme families Type Structure
X20403 Thioesterase Pyridine Triazol Cyclopropyl
ZTL-11 ACHE GSK-3 kinase inhibitor Carboxamide Multitarget Triazol Indole Cyclopropyl beta-carboline
ZLWH-23 ACHE Piperidine GSK-3 kinase inhibitor Carboxamide Multitarget Indole Cyclopropyl beta-carboline
3-cyano-N-cyclopropylbenzenesulfonamide PAF-Acetylhydrolase Cyanide Sulfonamide Cyclopropyl Sulfur Compound Benzenesulfonamide
FL217 Epoxide_hydrolase Multitarget PPARgamma ligand Cyclopropyl Sulfur Compound Sulfonamide Indole
ZINC10109382-S0A-3WK4 Epoxide_hydrolase Urea derivative Cyclopropyl
CHEMBL3402239-4A5-4Y2V Epoxide_hydrolase Acetate Cyclopropyl Pyrazole
Pyrrole-6-6YV4 Pectinacetylesterase-Notum Cyclopropyl Pyrrole_Pyrrolidine-derivative
Pyrrole-7-6YUW Pectinacetylesterase-Notum Pyrrole_Pyrrolidine-derivative Cyclopropyl
LIPG-inhib-Compound8i Lipoprotein_Lipase Cyanide Benzothiazol Sulfur Compound Cyclopropyl
LIPG-inhib-Compound32 Lipoprotein_Lipase Pyridine Benzothiazol Sulfur Compound Sulfonyl Cyclopropyl
LP-922056 Pectinacetylesterase-Notum Pyrimidine Sulfur Compound Cyclopropyl
FG1912 ACHE GSK-3 kinase inhibitor Multitarget Pyridine Piperidine Cyclopropyl Carboxamide Derivative of Donepezil
GD29 ACHE GSK-3 kinase inhibitor Multitarget Thiazole Pyridine Piperidine Cyclopropyl Carboxamide Derivative of Donepezil
GT15 ACHE Derivative of Tacrine GSK-3 kinase inhibitor Multitarget Carboxamide Pyridine Thiazole Cyclopropyl
AS2586144 Epoxide_hydrolase Piperidine Benzoate Cyclopropyl
CHEMBL1615212 Epoxide_hydrolase Cyanide Cyclopropyl
CHEMBL1615216 Epoxide_hydrolase Piperidine Urea derivative Cyclopropyl Carboxamide Oxadiazol
Flouroolefin-1 DPP4N_Peptidase_S9 Sulfur Compound Pyrrolidine Cyclopropyl Oxadiazol
Flouroolefin-2 DPP4N_Peptidase_S9 Sulfur Compound Cyclopropyl Oxadiazol Sulfonyl
5AM1-I5T Epoxide_hydrolase Piperidine Carboxamide Cyclopropyl Chromen
CHEMBL3401634 Epoxide_hydrolase Cyclopropyl Urea derivative
CHEMBL3114611 Epoxide_hydrolase Cyclopropyl Piperidine Urea derivative Carboxamide
CHEMBL1086968 S9N_PPCE_Peptidase_S9 Peptide Thiazolidine Cyclopropyl Indole Sulfur Compound
Permethrin Pyrethroid Insecticide Not A\/B H target Phenoxyphenyl Cyclopropyl