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Cyclopropyl

General

Cyclopropane is the cycloalkane with the molecular formula (CH2)3, consisting of three methylene groups (CH2) linked to each other to form a ring. The small size of the ring creates substantial ring strain in the structure. Building block for many inhibitors of enzymes.
Inhibitor Main targeted enzyme families Type Structure
Cyclopentyl-pyridyl-benzoxazol-cyclopropyl-triazol-azaspiro-heptan-methanone-Cpd29 Monoglyceridelipase_lysophospholip Benzoxazol Pyridine Piperazine Triazol Azaspiro Cyclopropyl
Chlorooxazolo-pyridin-piperazin-cyclobutylcyclopropyl-pyridyl-benzoxazol-methanone-Cpd27 Monoglyceridelipase_lysophospholip Benzoxazol Pyridine Piperazine Cyclobutyl Cyclopropyl Organochlorine
FP30 Epoxide_hydrolase Imidazole Cyclopropyl Trifluoro Carboxamide
Ticagrelor Pancreatic_lipase Not AlphaBeta Hydrolase target Drug Pyrimidine Triazol Sulfur Compound Antiplatelet Cyclopropyl
SCHEMBL24050193 BCHE Fluoren Cyclopropyl Multitarget BACE1-inhibitor anti-Abeta-aggregation GABA-transporter-inhibitor
LE-77 Carb_B_Chordata Cyclopropyl Oxazole Organochlorine
CHEMBL4278686 ACHE GSK-3 kinase inhibitor Derivative of Tacrine Acridine Multitarget Thiazole Carboxamide Pyridine Cyclopropyl Sulfur Compound
X20403 Thioesterase Pyridine Triazol Cyclopropyl Dimethoxyphenyl
ZTL-11 ACHE GSK-3 kinase inhibitor Carboxamide Multitarget Triazol Indole Cyclopropyl beta-carboline
ZLWH-23 ACHE Piperidine GSK-3 kinase inhibitor Carboxamide Multitarget Indole Cyclopropyl beta-carboline
3-cyano-N-cyclopropylbenzenesulfonamide PAF-Acetylhydrolase Cyanide Sulfonamide Cyclopropyl Sulfur Compound Benzenesulfonamide
FL217 Epoxide_hydrolase Multitarget PPARgamma ligand Cyclopropyl Sulfur Compound Sulfonamide Indole
ZINC10109382-S0A-3WK4 Epoxide_hydrolase Urea derivative Cyclopropyl
CHEMBL3402239-4A5-4Y2V Epoxide_hydrolase Acetate Cyclopropyl Pyrazole
Pyrrole-6-6YV4 Pectinacetylesterase-Notum Cyclopropyl Pyrrole_Pyrrolidine-derivative
Pyrrole-7-6YUW Pectinacetylesterase-Notum Pyrrole_Pyrrolidine-derivative Cyclopropyl
LIPG-inhib-Compound8i Lipoprotein_Lipase Cyanide Benzothiazol Sulfur Compound Cyclopropyl
LIPG-inhib-Compound32 Lipoprotein_Lipase Pyridine Benzothiazol Sulfur Compound Sulfonyl Cyclopropyl
LP-922056 Pectinacetylesterase-Notum Pyrimidine Sulfur Compound Cyclopropyl Organochlorine
FG1912 ACHE GSK-3 kinase inhibitor Multitarget Pyridine Piperidine Cyclopropyl Carboxamide Derivative of Donepezil
GD29 ACHE GSK-3 kinase inhibitor Multitarget Thiazole Pyridine Piperidine Cyclopropyl Carboxamide Sulfur Compound Derivative of Donepezil
GT15 ACHE Derivative of Tacrine Acridine GSK-3 kinase inhibitor Sulfur Compound Multitarget Carboxamide Pyridine Thiazole Cyclopropyl
AS2586144 Epoxide_hydrolase Piperidine Benzoate Cyclopropyl
CHEMBL1615212 Epoxide_hydrolase Cyanide Cyclopropyl
CHEMBL1615216 Epoxide_hydrolase Piperidine Urea derivative Cyclopropyl Carboxamide Oxadiazol
Flouroolefin-1 DPP4N_Peptidase_S9 Sulfur Compound Pyrrolidine Cyclopropyl Oxadiazol
Flouroolefin-2 DPP4N_Peptidase_S9 Sulfur Compound Cyclopropyl Oxadiazol Sulfonyl
5AM1-I5T Epoxide_hydrolase Piperidine Carboxamide Cyclopropyl Chromen
CHEMBL3401634 Epoxide_hydrolase Cyclopropyl Urea derivative
CHEMBL3114611 Epoxide_hydrolase Cyclopropyl Piperidine Urea derivative Carboxamide
CHEMBL1086968 S9N_PPCE_Peptidase_S9 Peptide Thiazolidine Cyclopropyl Indole Sulfur Compound
Permethrin Pyrethroid Insecticide Not AlphaBeta Hydrolase target Phenoxyphenyl Cyclopropyl
Cyclopentyl-pyridyl-benzoxazol-cyclopropyl-triazol-azaspiro-heptan-methanone-Cpd29 Monoglyceridelipase_lysophospholip Benzoxazol Pyridine Piperazine Triazol Azaspiro Cyclopropyl
Chlorooxazolo-pyridin-piperazin-cyclobutylcyclopropyl-pyridyl-benzoxazol-methanone-Cpd27 Monoglyceridelipase_lysophospholip Benzoxazol Pyridine Piperazine Cyclobutyl Cyclopropyl Organochlorine
FP30 Epoxide_hydrolase Imidazole Cyclopropyl Trifluoro Carboxamide
Ticagrelor Pancreatic_lipase Not AlphaBeta Hydrolase target Drug Pyrimidine Triazol Sulfur compound Antiplatelet Cyclopropyl
SCHEMBL24050193 BCHE Fluoren Cyclopropyl Multitarget BACE1-inhibitor anti-Abeta-aggregation GABA-transporter-inhibitor
LE-77 Carb_B_Chordata Cyclopropyl Oxazole Organochlorine
CHEMBL4278686 ACHE GSK-3 kinase inhibitor Derivative of Tacrine Acridine Multitarget Thiazole Carboxamide Pyridine Cyclopropyl Sulfur compound
X20403 Thioesterase Pyridine Triazol Cyclopropyl Dimethoxyphenyl
DTNP BCHE Fluorescent Probe Hemicyanine Near-Infrared fluorescent Probe Triazol Carboxamide Xanthene Cyclopropyl HDAC inhibitor
ZTL-11 ACHE GSK-3 kinase inhibitor Carboxamide Multitarget Triazol Indole Cyclopropyl beta-carboline
ZLWH-23 ACHE Piperidine GSK-3 kinase inhibitor Carboxamide Multitarget Indole Cyclopropyl beta-carboline
3-cyano-N-cyclopropylbenzenesulfonamide PAF-Acetylhydrolase Cyanide Sulfonamide Cyclopropyl Sulfur compound Benzenesulfonamide
FL217 Epoxide_hydrolase Multitarget PPARgamma ligand Cyclopropyl Sulfur compound Sulfonamide Indole
ZINC10109382-S0A-3WK4 Epoxide_hydrolase Urea derivative Cyclopropyl
CHEMBL3402239-4A5-4Y2V Epoxide_hydrolase Acetate Cyclopropyl Pyrazole
Pyrrole-6-6YV4 Pectinacetylesterase-Notum Cyclopropyl Pyrrole_Pyrrolidine-derivative
Pyrrole-7-6YUW Pectinacetylesterase-Notum Pyrrole_Pyrrolidine-derivative Cyclopropyl
LIPG-inhib-Compound8i Lipoprotein_Lipase Cyanide Benzothiazol Sulfur compound Cyclopropyl
LIPG-inhib-Compound32 Lipoprotein_Lipase Pyridine Benzothiazol Sulfur compound Sulfonyl Cyclopropyl
LP-922056 Pectinacetylesterase-Notum Pyrimidine Sulfur compound Cyclopropyl Organochlorine
FG1912 ACHE GSK-3 kinase inhibitor Multitarget Pyridine Piperidine Cyclopropyl Carboxamide Derivative of Donepezil
GD29 ACHE GSK-3 kinase inhibitor Multitarget Thiazole Pyridine Piperidine Cyclopropyl Carboxamide Sulfur compound Derivative of Donepezil
GT15 ACHE Derivative of Tacrine Acridine GSK-3 kinase inhibitor Sulfur compound Multitarget Carboxamide Pyridine Thiazole Cyclopropyl
AS2586144 Epoxide_hydrolase Piperidine Benzoate Cyclopropyl
CHEMBL1615212 Epoxide_hydrolase Cyanide Cyclopropyl
CHEMBL1615216 Epoxide_hydrolase Piperidine Urea derivative Cyclopropyl Carboxamide Oxadiazol
Flouroolefin-1 DPP4N_Peptidase_S9 Sulfur compound Pyrrolidine Cyclopropyl Oxadiazol
Flouroolefin-2 DPP4N_Peptidase_S9 Sulfur compound Cyclopropyl Oxadiazol Sulfonyl
5AM1-I5T Epoxide_hydrolase Piperidine Carboxamide Cyclopropyl Chromen
CHEMBL3401634 Epoxide_hydrolase Cyclopropyl Urea derivative
CHEMBL3114611 Epoxide_hydrolase Cyclopropyl Piperidine Urea derivative Carboxamide
CHEMBL1086968 S9N_PPCE_Peptidase_S9 Peptide Thiazolidine Cyclopropyl Indole Sulfur compound Drug
Permethrin Pyrethroid Insecticide Not AlphaBeta Hydrolase target Phenoxyphenyl Cyclopropyl
Cyclopentyl-pyridyl-benzoxazol-cyclopropyl-triazol-azaspiro-heptan-methanone-Cpd29 Monoglyceridelipase_lysophospholip Benzoxazol Pyridine Piperazine Triazol Azaspiro Cyclopropyl
Chlorooxazolo-pyridin-piperazin-cyclobutylcyclopropyl-pyridyl-benzoxazol-methanone-Cpd27 Monoglyceridelipase_lysophospholip Benzoxazol Pyridine Piperazine Cyclobutyl Cyclopropyl Organochlorine
FP30 Epoxide_hydrolase Imidazole Cyclopropyl Trifluoro Carboxamide
Ticagrelor Pancreatic_lipase Not AlphaBeta Hydrolase target Drug Pyrimidine Triazol Sulfur compound Antiplatelet Cyclopropyl
SCHEMBL24050193 BCHE Fluoren Cyclopropyl Multitarget BACE1-inhibitor anti-Abeta-aggregation GABA-transporter-inhibitor
LE-77 Carb_B_Chordata Cyclopropyl Oxazole Organochlorine
CHEMBL4278686 ACHE GSK-3 kinase inhibitor Derivative of Tacrine Acridine Multitarget Thiazole Carboxamide Pyridine Cyclopropyl Sulfur compound
X20403 Thioesterase Pyridine Triazol Cyclopropyl Dimethoxyphenyl
DTNP BCHE Fluorescent Probe Hemicyanine Near-Infrared fluorescent Probe Triazol Carboxamide Xanthene Cyclopropyl HDAC inhibitor
ZTL-11 ACHE GSK-3 kinase inhibitor Carboxamide Multitarget Triazol Indole Cyclopropyl beta-carboline
ZLWH-23 ACHE Piperidine GSK-3 kinase inhibitor Carboxamide Multitarget Indole Cyclopropyl beta-carboline
3-cyano-N-cyclopropylbenzenesulfonamide PAF-Acetylhydrolase Cyanide Sulfonamide Cyclopropyl Sulfur compound Benzenesulfonamide
FL217 Epoxide_hydrolase Multitarget PPARgamma ligand Cyclopropyl Sulfur compound Sulfonamide Indole
ZINC10109382-S0A-3WK4 Epoxide_hydrolase Urea derivative Cyclopropyl
CHEMBL3402239-4A5-4Y2V Epoxide_hydrolase Acetate Cyclopropyl Pyrazole
Pyrrole-6-6YV4 Pectinacetylesterase-Notum Cyclopropyl Pyrrole_Pyrrolidine-derivative
Pyrrole-7-6YUW Pectinacetylesterase-Notum Pyrrole_Pyrrolidine-derivative Cyclopropyl
LIPG-inhib-Compound8i Lipoprotein_Lipase Cyanide Benzothiazol Sulfur compound Cyclopropyl
LIPG-inhib-Compound32 Lipoprotein_Lipase Pyridine Benzothiazol Sulfur compound Sulfonyl Cyclopropyl
LP-922056 Pectinacetylesterase-Notum Pyrimidine Sulfur compound Cyclopropyl Organochlorine
FG1912 ACHE GSK-3 kinase inhibitor Multitarget Pyridine Piperidine Cyclopropyl Carboxamide Derivative of Donepezil
GD29 ACHE GSK-3 kinase inhibitor Multitarget Thiazole Pyridine Piperidine Cyclopropyl Carboxamide Sulfur compound Derivative of Donepezil
GT15 ACHE Derivative of Tacrine Acridine GSK-3 kinase inhibitor Sulfur compound Multitarget Carboxamide Pyridine Thiazole Cyclopropyl
AS2586144 Epoxide_hydrolase Piperidine Benzoate Cyclopropyl
CHEMBL1615212 Epoxide_hydrolase Cyanide Cyclopropyl
CHEMBL1615216 Epoxide_hydrolase Piperidine Urea derivative Cyclopropyl Carboxamide Oxadiazol
Flouroolefin-1 DPP4N_Peptidase_S9 Sulfur compound Pyrrolidine Cyclopropyl Oxadiazol
Flouroolefin-2 DPP4N_Peptidase_S9 Sulfur compound Cyclopropyl Oxadiazol Sulfonyl
5AM1-I5T Epoxide_hydrolase Piperidine Carboxamide Cyclopropyl Chromen
CHEMBL3401634 Epoxide_hydrolase Cyclopropyl Urea derivative
CHEMBL3114611 Epoxide_hydrolase Cyclopropyl Piperidine Urea derivative Carboxamide
CHEMBL1086968 S9N_PPCE_Peptidase_S9 Peptide Thiazolidine Cyclopropyl Indole Sulfur compound Drug
Permethrin Pyrethroid Insecticide Not AlphaBeta Hydrolase target Phenoxyphenyl Cyclopropyl