Triclosan
It is widely used as a preservative and antimicrobial agent in personal care products such as soaps, skin creams, toothpaste and deodorants as well as in household items such as plastic chopping boards, sports equipment and shoes. It has a role as an antibacterial agent, a fungicide, an EC 1.5.1.3 (dihydrofolate reductase) inhibitor, an antimalarial, an EC 1.3.1.9 [enoyl-[acyl-carrier-protein] reductase (NADH)] inhibitor, Fatty acid synthase (FASN) inhibitor, a xenobiotic, a persistent organic pollutant and a drug allergen.
General
Type : Not AlphaBeta Hydrolase target, Fungicide
Chemical_Nomenclature : 5-chloro-2-(2,4-dichlorophenoxy)phenol
Canonical SMILES : C1=CC(=C(C=C1Cl)O)OC2=C(C=C(C=C2)Cl)Cl
InChI : InChI=1S\/C12H7Cl3O2\/c13-7-1-3-11(9(15)5-7)17-12-4-2-8(14)6-10(12)16\/h1-6,16H
InChIKey : XEFQLINVKFYRCS-UHFFFAOYSA-N
Other name(s) : 5-CHLORO-2-(2,4-DICHLOROPHENOXY)PHENOL || Cloxifenolum || 2,4,4'-Trichloro-2'-hydroxydiphenyl ether || CHEBI:164200 || CHEMBL849
MW : 289.5
Formula : C12H7Cl3O2
CAS_number : 3380-34-5
PubChem : 5564
UniChem : XEFQLINVKFYRCS-UHFFFAOYSA-N
Target
References (26)
| Title : Biochemical and physiological alterations caused by Diuron and Triclosan in mussels (Mytilus galloprovincialis) - Bouzidi_2024_Pestic.Biochem.Physiol_198_105714 |
| Author(s) : Bouzidi I , Mougin K , Beyrem H , Sellami B |
| Ref : Pestic Biochem Physiol , 198 :105714 , 2024 |
| Abstract : |
| PubMedSearch : Bouzidi_2024_Pestic.Biochem.Physiol_198_105714 |
| PubMedID: 38225063 |
| Title : Assessment of triclosan induced histopathological and biochemical alterations, and molecular docking simulation analysis of acetylcholinesterase enzyme in the gills of fish, Cyprinus carpio - Tripathi_2024_Environ.Sci.Pollut.Res.Int__ |
| Author(s) : Tripathi A , Gayen T , Maitra P , Kumari U , Mittal S , Mittal AK |
| Ref : Environ Sci Pollut Res Int , : , 2024 |
| Abstract : |
| PubMedSearch : Tripathi_2024_Environ.Sci.Pollut.Res.Int__ |
| PubMedID: 38842779 |
| Title : Physiological Impairment and Biochemical Modifications Induced by Triclosan in Mediterranean Mussels - Bouzidi_2023_Animals.(Basel)_13_ |
| Author(s) : Bouzidi I , Mougin K , Beyrem H , Alghonaim MI , Alsalamah SA , Qurtam AA , Mahmoudi E , Boufahja F , Sellami B |
| Ref : Animals (Basel) , 13 : , 2023 |
| Abstract : |
| PubMedSearch : Bouzidi_2023_Animals.(Basel)_13_ |
| PubMedID: 36830370 |
| Title : Acute and chronic effects of triclosan on the behavior, physiology, and multigenerational characteristics of the water flea Moina macrocopa - Do_2023_Comp.Biochem.Physiol.C.Toxicol.Pharmacol__109810 |
| Author(s) : Do SD , Haque MN , Kim J , Im DH , Rhee JS |
| Ref : Comparative Biochemistry & Physiology C Toxicol Pharmacol , :109810 , 2023 |
| Abstract : |
| PubMedSearch : Do_2023_Comp.Biochem.Physiol.C.Toxicol.Pharmacol__109810 |
| PubMedID: 38061617 |
| Title : Precision cut tissue slices to investigate the effects of triclosan exposure in Mytilus galloprovincialis - Hosseinzadeh_2022_Toxicol.In.Vitro__105477 |
| Author(s) : Hosseinzadeh M , Gilabert A , Porte C |
| Ref : Toxicol In Vitro , :105477 , 2022 |
| Abstract : |
| PubMedSearch : Hosseinzadeh_2022_Toxicol.In.Vitro__105477 |
| PubMedID: 36122805 |
| Title : Combined effects of polyethylene spiked with the antimicrobial triclosan on the swamp ghost crab (Ucides cordatus\; Linnaeus, 1763) - Nobre_2022_Chemosphere__135169 |
| Author(s) : Nobre CR , Moreno BB , Alves AV , de Lima Rosa J , Fontes MK , Campos BG , Silva LFD , Almeida Duarte LF , Abessa DMS , Choueri RB , Gusso-Choueri PK , Pereira CDS |
| Ref : Chemosphere , :135169 , 2022 |
| Abstract : |
| PubMedSearch : Nobre_2022_Chemosphere__135169 |
| PubMedID: 35671813 |
| Title : Study on the toxic-mechanism of triclosan chronic exposure to zebrafish (Danio rerio) based on gut-brain axis - Wang_2022_Sci.Total.Environ__156936 |
| Author(s) : Wang Y , Song J , Wang X , Qian Q , Wang H |
| Ref : Sci Total Environ , :156936 , 2022 |
| Abstract : |
| PubMedSearch : Wang_2022_Sci.Total.Environ__156936 |
| PubMedID: 35772538 |
| Title : Multibiomarker responses in Danio rerio after exposure to sediment spiked with triclosan - Sager_2021_An.Acad.Bras.Cienc_93_e20201938 |
| Author(s) : Sager E , Rossi A , Loughlin TM , Marino D , Torre F |
| Ref : An Acad Bras Cienc , 93 :e20201938 , 2021 |
| Abstract : |
| PubMedSearch : Sager_2021_An.Acad.Bras.Cienc_93_e20201938 |
| PubMedID: 34550207 |
| Title : Oxidative stress responses after exposure to triclosan sublethal concentrations: an integrated biomarker approach with a native (Corydoras paleatus) and a model fish species (Danio rerio) - Sager_2021_J.Toxicol.Environ.Health.A__1 |
| Author(s) : Sager E , Scarcia P , Marino D , Mac Loughlin T , Rossi A , de La Torre F |
| Ref : J Toxicol Environ Health A , :1 , 2021 |
| Abstract : |
| PubMedSearch : Sager_2021_J.Toxicol.Environ.Health.A__1 |
| PubMedID: 34879786 |
| Title : Enzymatic activity changes in striped catfish Pseudoplatystoma magdaleniatum, induced by exposure to different concentrations of ibuprofen and triclosan - Gallego_2021_Chemosphere_271_129399 |
| Author(s) : Gallego RS , Penuela GA , Martinez-Lopez E |
| Ref : Chemosphere , 271 :129399 , 2021 |
| Abstract : |
| PubMedSearch : Gallego_2021_Chemosphere_271_129399 |
| PubMedID: 33482525 |
| Title : New insights into inhibitory nature of triclosan on acetylcholinesterase activity - Pullaguri_2021_Toxicology__153080 |
| Author(s) : Pullaguri N , R AK , Bhargava A |
| Ref : Toxicology , :153080 , 2021 |
| Abstract : |
| PubMedSearch : Pullaguri_2021_Toxicology__153080 |
| PubMedID: 34942273 |
| Title : Triclosan affects motor function in zebrafish larva by inhibiting ache and syn2a genes - Pullaguri_2020_Chemosphere__128930 |
| Author(s) : Pullaguri N , Grover P , Abhishek S , Rajakumara E , Bhargava Y , Bhargava A |
| Ref : Chemosphere , :128930 , 2020 |
| Abstract : |
| PubMedSearch : Pullaguri_2020_Chemosphere__128930 |
| PubMedID: 33223207 |
| Gene_locus related to this paper: danre-ACHE |
| Title : Biomarkers for the toxicity of sublethal concentrations of triclosan to the early life stages of carps - Dar_2020_Sci.Rep_10_17322 |
| Author(s) : Dar OI , Sharma S , Singh K , Sharma A , Bhardwaj R , Kaur A |
| Ref : Sci Rep , 10 :17322 , 2020 |
| Abstract : |
| PubMedSearch : Dar_2020_Sci.Rep_10_17322 |
| PubMedID: 33057045 |
| Title : A multi-biomarker approach using integrated biomarker response to assess the effect of pH on triclosan toxicity in Pangasianodon hypophthalmus (Sauvage, 1878) - Paul_2020_Environ.Pollut_260_114001 |
| Author(s) : Paul T , Kumar S , Shukla SP , Pal P , Kumar K , Poojary N , Biswal A , Mishra A |
| Ref : Environ Pollut , 260 :114001 , 2020 |
| Abstract : |
| PubMedSearch : Paul_2020_Environ.Pollut_260_114001 |
| PubMedID: 32041020 |
| Title : Sublethal effects of triclosan and triclocarban at environmental concentrations in silver catfish (Rhamdia quelen) embryos - Gomes_2020_Chemosphere_263_127985 |
| Author(s) : Gomes MF , de Carvalho Soares de Paula V , Rocha Martins LR , Esquivel Garcia JR , Yamamoto FY , Martins de Freitas A |
| Ref : Chemosphere , 263 :127985 , 2020 |
| Abstract : |
| PubMedSearch : Gomes_2020_Chemosphere_263_127985 |
| PubMedID: 32854011 |
| Title : Sublethal concentrations of triclosan elicited oxidative stress, DNA damage, and histological alterations in the liver and brain of adult zebrafish - Gyimah_2020_Environ.Sci.Pollut.Res.Int__ |
| Author(s) : Gyimah E , Dong X , Qiu W , Zhang Z , Xu H |
| Ref : Environ Sci Pollut Res Int , : , 2020 |
| Abstract : |
| PubMedSearch : Gyimah_2020_Environ.Sci.Pollut.Res.Int__ |
| PubMedID: 32157542 |
| Title : Effects of triclosan on early development of Solea senegalensis: from biochemical to individual level - Araujo_2019_Chemosphere_235_885 |
| Author(s) : Araujo MJ , Quintaneiro C , Soares A , Monteiro MS |
| Ref : Chemosphere , 235 :885 , 2019 |
| Abstract : |
| PubMedSearch : Araujo_2019_Chemosphere_235_885 |
| PubMedID: 31284137 |
| Title : Effect of temperature on triclosan toxicity in Pangasianodon hypophthalmus (Sauvage, 1878): Hematology, biochemistry and genotoxicity evaluation - Paul_2019_Sci.Total.Environ_668_104 |
| Author(s) : Paul T , Shukla SP , Kumar K , Poojary N , Kumar S |
| Ref : Sci Total Environ , 668 :104 , 2019 |
| Abstract : |
| PubMedSearch : Paul_2019_Sci.Total.Environ_668_104 |
| PubMedID: 30852190 |
| Title : Triclosan alters adult zebrafish behavior and targets acetylcholinesterase activity and expression - Pullaguri_2019_Environ.Toxicol.Pharmacol_75_103311 |
| Author(s) : Pullaguri N , Nema S , Bhargava Y , Bhargava A |
| Ref : Environ Toxicol Pharmacol , 75 :103311 , 2019 |
| Abstract : |
| PubMedSearch : Pullaguri_2019_Environ.Toxicol.Pharmacol_75_103311 |
| PubMedID: 31841724 |
| Title : Triclosan toxicity alters behavioral and hematological parameters and vital antioxidant and neurological enzymes in Pangasianodon hypophthalmus (Sauvage, 1878) - Sahu_2018_Aquat.Toxicol_202_145 |
| Author(s) : Sahu VK , Karmakar S , Kumar S , Shukla SP , Kumar K |
| Ref : Aquat Toxicol , 202 :145 , 2018 |
| Abstract : |
| PubMedSearch : Sahu_2018_Aquat.Toxicol_202_145 |
| PubMedID: 30031254 |
| Title : Effects of prenatal exposure to triclosan on the liver transcriptome in chicken embryos - Guo_2018_Toxicol.Appl.Pharmacol_347_23 |
| Author(s) : Guo J , Ito S , Nguyen HT , Yamamoto K , Tanoue R , Kunisue T , Iwata H |
| Ref : Toxicol Appl Pharmacol , 347 :23 , 2018 |
| Abstract : |
| PubMedSearch : Guo_2018_Toxicol.Appl.Pharmacol_347_23 |
| PubMedID: 29596926 |
| Title : Effects of 4-MBC and triclosan in embryos of the frog Pelophylax perezi - Martins_2017_Chemosphere_178_325 |
| Author(s) : Martins D , Monteiro MS , Soares AM , Quintaneiro C |
| Ref : Chemosphere , 178 :325 , 2017 |
| Abstract : |
| PubMedSearch : Martins_2017_Chemosphere_178_325 |
| PubMedID: 28334672 |
| Title : Vulnerability of marsh frog Pelophylax ridibundus to the typical wastewater effluents ibuprofen, triclosan and estrone, detected by multi-biomarker approach - Falfushynska_2017_Comp.Biochem.Physiol.C.Toxicol.Pharmacol_202_26 |
| Author(s) : Falfushynska HI , Gnatyshyna LL , Horyn O , Stoliar OB |
| Ref : Comparative Biochemistry & Physiology C Toxicol Pharmacol , 202 :26 , 2017 |
| Abstract : |
| PubMedSearch : Falfushynska_2017_Comp.Biochem.Physiol.C.Toxicol.Pharmacol_202_26 |
| PubMedID: 28757214 |
| Title : A multi-biomarker approach to assess effects of Triclosan in the clam Ruditapes philippinarum - Matozzo_2012_Mar.Environ.Res_74_40 |
| Author(s) : Matozzo V , Formenti A , Donadello G , Marin MG |
| Ref : Mar Environ Research , 74 :40 , 2012 |
| Abstract : |
| PubMedSearch : Matozzo_2012_Mar.Environ.Res_74_40 |
| PubMedID: 22212174 |
| Title : Toxicology in the fast lane: application of high-throughput bioassays to detect modulation of key enzymes and receptors - Morisseau_2009_Environ.Health.Perspect_117_1867 |
| Author(s) : Morisseau C , Merzlikin O , Lin A , He G , Feng W , Padilla I , Denison MS , Pessah IN , Hammock BD |
| Ref : Environmental Health Perspectives , 117 :1867 , 2009 |
| Abstract : |
| PubMedSearch : Morisseau_2009_Environ.Health.Perspect_117_1867 |
| PubMedID: 20049205 |
| Title : Effects of triclosan on zebrafish early-life stages and adults - Oliveira_2009_Environ.Sci.Pollut.Res.Int_16_679 |
| Author(s) : Oliveira R , Domingues I , Koppe Grisolia C , Soares AM |
| Ref : Environ Sci Pollut Res Int , 16 :679 , 2009 |
| Abstract : |
| PubMedSearch : Oliveira_2009_Environ.Sci.Pollut.Res.Int_16_679 |
| PubMedID: 19283420 |