VAV-19
IC50 eleelAChE 0.177 +/- 0.05 MAO-B 6.06 +/- 0.69
General
Type : Monoamine-oxidase-inhibitor, Multitarget, Quinazoline, Piperazine, Alkyne
Chemical_Nomenclature : 4-(4-benzylpiperazin-1-yl)-2-(3-methoxy-4-(prop-2-yn-1-yloxy)phenyl)quinazoline
Canonical SMILES : C1=CC=C2C(=C1)C(=NC(=N2)C3=CC=C(C(=C3)OC)OCC#C)N4CCN(CC4)CC5=CC=CC=C5
InChI : InChI=1S\/C29H28N4O2\/c1-3-19-35-26-14-13-23(20-27(26)34-2)28-30-25-12-8-7-11-24(25)29(31-28)33-17-15-32(16-18-33)21-22-9-5-4-6-10-22\/h1,4-14,20H,15-19,21H2,2H3
InChIKey : PXZCNYHBTYKZJQ-UHFFFAOYSA-N
Other name(s) :
Target
Families : VAV-19 ligand of proteins in family
ACHE
References (3)
| Title : In vitro and in vivo Investigations of 4-Substituted 2-Phenylquinazoline derivatives as multipotent ligands for the treatment of Alzheimer's disease - Kumar_2025_Bioorg.Chem_155_108126 |
| Author(s) : Kumar V , Jangid K , Kumar N , Mishra J , Arora T , Dwivedi AR , Kumar P , Bhatti JS , Parkash J |
| Ref : Bioorg Chem , 155 :108126 , 2025 |
| Abstract : |
| PubMedSearch : Kumar_2025_Bioorg.Chem_155_108126 |
| PubMedID: 39798452 |
| Title : In vitro and in vivo Investigations of 4-Substituted 2-Phenylquinazoline derivatives as multipotent ligands for the treatment of Alzheimer's disease - Kumar_2025_Bioorg.Chem_155_108126 |
| Author(s) : Kumar V , Jangid K , Kumar N , Mishra J , Arora T , Dwivedi AR , Kumar P , Bhatti JS , Parkash J |
| Ref : Bioorg Chem , 155 :108126 , 2025 |
| Abstract : |
| PubMedSearch : Kumar_2025_Bioorg.Chem_155_108126 |
| PubMedID: 39798452 |
| Title : In vitro and in vivo Investigations of 4-Substituted 2-Phenylquinazoline derivatives as multipotent ligands for the treatment of Alzheimer's disease - Kumar_2025_Bioorg.Chem_155_108126 |
| Author(s) : Kumar V , Jangid K , Kumar N , Mishra J , Arora T , Dwivedi AR , Kumar P , Bhatti JS , Parkash J |
| Ref : Bioorg Chem , 155 :108126 , 2025 |
| Abstract : |
| PubMedSearch : Kumar_2025_Bioorg.Chem_155_108126 |
| PubMedID: 39798452 |