C14-palmitoyl-MAG-like-phosphonate
mimics the Monoacylglycerol MAG of identical size (here the 1-palmitoylglycerol Monopalmitin (C16:0)). The adduct on the active serine lacks the leaving group 4-nitrophenol
General
Type : Organophosphate,pNP,Lipase inhibitor,Analogue of substrate,Azido
Chemical_Nomenclature : 3-[hydroxy(tetradecoxy)phosphoryl]propylimino-iminoazanium
Canonical SMILES : CCCCCCCCCCCCCCOP(=O)(CCCN=[N+]=N)O
InChI : InChI=1S\/C17H36N3O3P\/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-23-24(21,22)17-14-15-19-20-18\/h18H,2-17H2,1H3\/p+1
InChIKey : DBFCYRAMTWKWQC-UHFFFAOYSA-O
Other name(s) : Tetradecyl Hydrogen (R)-(3-Azidopropyl)phosphonate,1QY
MW : 362.47 || 482.55
Formula : C17H37N3O3P+ || C23H39N4O5P
CAS_number :
PubChem : 71710908
UniChem : DBFCYRAMTWKWQC-UHFFFAOYSA-O
IUPHAR :
Wikipedia :
Target
Families : C14-palmitoyl-MAG-like-phosphonate ligand of proteins in family: CarbLipBact_2
Stucture : 4KE8 Crystal structure of monoacylglycerol lipase from Bacillus sp. H257 in complex with monopalmitoyl glycerol analogue
Protein : bac25-mglp
References (1)
| Title : Conformational plasticity and ligand binding of bacterial monoacylglycerol lipase - Rengachari_2013_J.Biol.Chem_288_31093 |
| Author(s) : Rengachari S , Aschauer P , Schittmayer M , Mayer N , Gruber K , Breinbauer R , Birner-Gruenberger R , Dreveny I , Oberer M |
| Ref : Journal of Biological Chemistry , 288 :31093 , 2013 |
| Abstract : Rengachari_2013_J.Biol.Chem_288_31093 |
| ESTHER : Rengachari_2013_J.Biol.Chem_288_31093 |
| PubMedSearch : Rengachari_2013_J.Biol.Chem_288_31093 |
| PubMedID: 24014019 |
| Gene_locus related to this paper: bac25-mglp |