PIRSF017388 Members of this group are esterases, lipases, and (possibly) other hydrolases of the alpha/beta hydrolase fold. The Bacillus stearothermophilus member, Est, has been characterized as a carboxylesterase (EC 3.1.1.1) involved in the detoxification of xenobiotics, and the Bacillus sp. member has been characterized as monoacylglycerol lipase. This family correspond to family XIII of the classification of Arpigny and Jaeger 1999. Family XIII was introduced by Ewis et al.(2004) and Liu et al. (2004). The closest family is Monoglyceridelipase_lysophospholip. The family XIII contains LipS Chow et al.. This family is composed of two sub families with different set of salt-bridges important for thermostability Charbonneau et al. (due to simultaneous publication of new families this family was numbered XV but really is a subset of familly XIII. See notice of this paper in Plos One)
Interpro : IPR012354 Esterase\/lipase
PIRSF : PIRSF017388 esterase\/lipase
Pdoc : No Pdoc
Pfam : No Pfam
Prints : No Print
EC Number : 3.1.1.1
Structures (13)
Genes Proteins in CarbLipBact_2 family (667)
No fragment of genes
Structures in CarbLipBact_2 family (13)Substrates in CarbLipBact_2 family (4)
Inhibitors in CarbLipBact_2 family (5)
Title : Conformational plasticity and ligand binding of bacterial monoacylglycerol lipase - Rengachari_2013_J.Biol.Chem_288_31093 |
Author(s) : Rengachari S , Aschauer P , Schittmayer M , Mayer N , Gruber K , Breinbauer R , Birner-Gruenberger R , Dreveny I , Oberer M |
Ref : Journal of Biological Chemistry , 288 :31093 , 2013 |
Abstract : Rengachari_2013_J.Biol.Chem_288_31093 |
ESTHER : Rengachari_2013_J.Biol.Chem_288_31093 |
PubMedSearch : Rengachari_2013_J.Biol.Chem_288_31093 |
PubMedID: 24014019 |
Gene_locus related to this paper: bac25-mglp |
Title : Role of key salt bridges in thermostability of G. thermodenitrificans EstGtA2: distinctive patterns within the new bacterial lipolytic enzyme family XV - Charbonneau_2013_PLoS.One_8_e76675 |
Author(s) : Charbonneau DM , Beauregard M |
Ref : PLoS ONE , 8 :e76675 , 2013 |
Abstract : Charbonneau_2013_PLoS.One_8_e76675 |
ESTHER : Charbonneau_2013_PLoS.One_8_e76675 |
PubMedSearch : Charbonneau_2013_PLoS.One_8_e76675 |
PubMedID: 24116134 |
Gene_locus related to this paper: geotd-g3jwz2 |
Title : A novel alkaliphilic bacillus esterase belongs to the 13(th) bacterial lipolytic enzyme family - Rao_2013_PLoS.One_8_e60645 |
Author(s) : Rao L , Xue Y , Zheng Y , Lu JR , Ma Y |
Ref : PLoS ONE , 8 :e60645 , 2013 |
Abstract : Rao_2013_PLoS.One_8_e60645 |
ESTHER : Rao_2013_PLoS.One_8_e60645 |
PubMedSearch : Rao_2013_PLoS.One_8_e60645 |
PubMedID: 23577139 |
Title : The structure of monoacylglycerol lipase from Bacillus sp. H257 reveals unexpected conservation of the cap architecture between bacterial and human enzymes - Rengachari_2012_Biochim.Biophys.Acta_1821_1012 |
Author(s) : Rengachari S , Bezerra GA , Riegler-Berket L , Gruber CC , Sturm C , Taschler U , Boeszoermenyi A , Dreveny I , Zimmermann R , Gruber K , Oberer M |
Ref : Biochimica & Biophysica Acta , 1821 :1012 , 2012 |
Abstract : Rengachari_2012_Biochim.Biophys.Acta_1821_1012 |
ESTHER : Rengachari_2012_Biochim.Biophys.Acta_1821_1012 |
PubMedSearch : Rengachari_2012_Biochim.Biophys.Acta_1821_1012 |
PubMedID: 22561231 |
Gene_locus related to this paper: bac25-mglp |
Title : The metagenome-derived enzymes LipS and LipT increase the diversity of known lipases - Chow_2012_PLoS.One_7_e47665 |
Author(s) : Chow J , Kovacic F , Dall Antonia Y , Krauss U , Fersini F , Schmeisser C , Lauinger B , Bongen P , Pietruszka J , Schmidt M , Menyes I , Bornscheuer UT , Eckstein M , Thum O , Liese A , Mueller-Dieckmann J , Jaeger KE , Streit WR |
Ref : PLoS ONE , 7 :e47665 , 2012 |
Abstract : Chow_2012_PLoS.One_7_e47665 |
ESTHER : Chow_2012_PLoS.One_7_e47665 |
PubMedSearch : Chow_2012_PLoS.One_7_e47665 |
PubMedID: 23112831 |
Gene_locus related to this paper: symth-q67mr3 , 9bact-k7qe48 |
Title : Cloning, expression, purification and preliminary X-ray analysis of a putative metagenome-derived lipase - Fersini_2012_Acta.Crystallogr.Sect.F.Struct.Biol.Cryst.Commun_68_923 |
Author(s) : Fersini F , Dall'Antonia Y , Chow J , Streit WR , Mueller-Dieckmann J |
Ref : Acta Crystallographica Sect F Struct Biol Cryst Commun , 68 :923 , 2012 |
Abstract : Fersini_2012_Acta.Crystallogr.Sect.F.Struct.Biol.Cryst.Commun_68_923 |
ESTHER : Fersini_2012_Acta.Crystallogr.Sect.F.Struct.Biol.Cryst.Commun_68_923 |
PubMedSearch : Fersini_2012_Acta.Crystallogr.Sect.F.Struct.Biol.Cryst.Commun_68_923 |
PubMedID: 22869123 |
Gene_locus related to this paper: symth-q67mr3 |
Title : A novel thermostable carboxylesterase from Geobacillus thermodenitrificans: evidence for a new carboxylesterase family - Charbonneau_2010_J.Biochem_148_299 |
Author(s) : Charbonneau DM , Meddeb-Mouelhi F , Beauregard M |
Ref : J Biochem , 148 :299 , 2010 |
Abstract : Charbonneau_2010_J.Biochem_148_299 |
ESTHER : Charbonneau_2010_J.Biochem_148_299 |
PubMedSearch : Charbonneau_2010_J.Biochem_148_299 |
PubMedID: 20587647 |
Gene_locus related to this paper: geotd-g3jwz2 |
Title : Molecular cloning and characterization of two thermostable carboxyl esterases from Geobacillus stearothermophilus - Ewis_2004_Gene_329_187 |
Author(s) : Ewis HE , Abdelal AT , Lu CD |
Ref : Gene , 329 :187 , 2004 |
Abstract : Ewis_2004_Gene_329_187 |
ESTHER : Ewis_2004_Gene_329_187 |
PubMedSearch : Ewis_2004_Gene_329_187 |
PubMedID: 15033540 |
Gene_locus related to this paper: geost-est30 , geost-est50 |
Title : Covalent reaction intermediate revealed in crystal structure of the Geobacillus stearothermophilus carboxylesterase Est30 - Liu_2004_J.Mol.Biol_342_551 |
Author(s) : Liu P , Wang YF , Ewis HE , Abdelal AT , Lu CD , Harrison RW , Weber IT |
Ref : Journal of Molecular Biology , 342 :551 , 2004 |
Abstract : Liu_2004_J.Mol.Biol_342_551 |
ESTHER : Liu_2004_J.Mol.Biol_342_551 |
PubMedSearch : Liu_2004_J.Mol.Biol_342_551 |
PubMedID: 15327954 |
Gene_locus related to this paper: geost-est30 |
Title : Monoacylglycerol lipase from moderately thermophilic Bacillus sp. strain H-257: molecular cloning, sequencing, and expression in Escherichia coli of the gene - Kitaura_2001_J.Biochem_129_397 |
Author(s) : Kitaura S , Suzuki K , Imamura S |
Ref : J Biochem , 129 :397 , 2001 |
Abstract : Kitaura_2001_J.Biochem_129_397 |
ESTHER : Kitaura_2001_J.Biochem_129_397 |
PubMedSearch : Kitaura_2001_J.Biochem_129_397 |
PubMedID: 11226879 |
Gene_locus related to this paper: bac25-mglp |
Title : Purification and characterization of a monoacylglycerol lipase from the moderately thermophilic Bacillus sp. H-257 - Imamura_2000_J.Biochem_127_419 |
Author(s) : Imamura S , Kitaura S |
Ref : J Biochem , 127 :419 , 2000 |
Abstract : Imamura_2000_J.Biochem_127_419 |
ESTHER : Imamura_2000_J.Biochem_127_419 |
PubMedSearch : Imamura_2000_J.Biochem_127_419 |
PubMedID: 10731713 |
Gene_locus related to this paper: bac25-mglp |
Title : Molecular cloning and structure of the gene for esterase from a thermophilic bacterium, Bacillus stearothermophilus IFO 12550 - |
Author(s) : Kugimiya W , Otani Y , Hashimoto Y |
Ref : Biosci Biotechnol Biochem , 56 :2074 , 1992 |
PubMedID: 1369099 |
Gene_locus related to this paper: geost-est30 |