CarbLipBact_2

Relationship

Family: CarbLipBact_2

Block: X

Parent Family: Hydrolase_4

Comment

PIRSF017388 Members of this group are esterases, lipases, and (possibly) other hydrolases of the alpha/beta hydrolase fold. The Bacillus stearothermophilus member, Est, has been characterized as a carboxylesterase (EC 3.1.1.1) involved in the detoxification of xenobiotics, and the Bacillus sp. member has been characterized as monoacylglycerol lipase. This family correspond to family XIII of the classification of Arpigny and Jaeger 1999. Family XIII was introduced by Ewis et al.(2004) and Liu et al. (2004). The closest family is Monoglyceridelipase_lysophospholip. The family XIII contains LipS Chow et al.. This family is composed of two sub families with different set of salt-bridges important for thermostability Charbonneau et al. (due to simultaneous publication of new families this family was numbered XV but really is a subset of familly XIII. See notice of this paper in Plos One)

Database

Interpro : IPR012354 Esterase\/lipase

PIRSF : PIRSF017388 esterase\/lipase

Pdoc : No Pdoc

Pfam : No Pfam

Prints : No Print

EC Number : 3.1.1.1

Sequences

Peptide in Fasta
Nucleotide in Fasta
Alignment with Multalin Text only
Seed alignment with MAFFT No colour
Alignment with MAFFT No colour
Dendrogram The dnd file

Structures (13)

Genes Proteins in CarbLipBact_2 family (667)

No fragment of genes

Structures in CarbLipBact_2 family (13)

Substrates in CarbLipBact_2 family (6)

Inhibitors in CarbLipBact_2 family (5)

References (12)

Title : A novel alkaliphilic bacillus esterase belongs to the 13(th) bacterial lipolytic enzyme family - Rao_2013_PLoS.One_8_e60645
Author(s) : Rao L , Xue Y , Zheng Y , Lu JR , Ma Y
Ref : PLoS ONE , 8 :e60645 , 2013
PubMedID: 23577139

Title : Conformational plasticity and ligand binding of bacterial monoacylglycerol lipase - Rengachari_2013_J.Biol.Chem_288_31093
Author(s) : Rengachari S , Aschauer P , Schittmayer M , Mayer N , Gruber K , Breinbauer R , Birner-Gruenberger R , Dreveny I , Oberer M
Ref : Journal of Biological Chemistry , 288 :31093 , 2013
PubMedID: 24014019
Gene_locus related to this paper: bac25-mglp

Title : Role of key salt bridges in thermostability of G. thermodenitrificans EstGtA2: distinctive patterns within the new bacterial lipolytic enzyme family XV - Charbonneau_2013_PLoS.One_8_e76675
Author(s) : Charbonneau DM , Beauregard M
Ref : PLoS ONE , 8 :e76675 , 2013
PubMedID: 24116134
Gene_locus related to this paper: geotd-g3jwz2

Title : The metagenome-derived enzymes LipS and LipT increase the diversity of known lipases - Chow_2012_PLoS.One_7_e47665
Author(s) : Chow J , Kovacic F , Dall Antonia Y , Krauss U , Fersini F , Schmeisser C , Lauinger B , Bongen P , Pietruszka J , Schmidt M , Menyes I , Bornscheuer UT , Eckstein M , Thum O , Liese A , Mueller-Dieckmann J , Jaeger KE , Streit WR
Ref : PLoS ONE , 7 :e47665 , 2012
PubMedID: 23112831
Gene_locus related to this paper: symth-q67mr3 , 9bact-k7qe48

Title : Cloning, expression, purification and preliminary X-ray analysis of a putative metagenome-derived lipase - Fersini_2012_Acta.Crystallogr.Sect.F.Struct.Biol.Cryst.Commun_68_923
Author(s) : Fersini F , Dall'Antonia Y , Chow J , Streit WR , Mueller-Dieckmann J
Ref : Acta Crystallographica Sect F Struct Biol Cryst Commun , 68 :923 , 2012
PubMedID: 22869123
Gene_locus related to this paper: symth-q67mr3

Title : The structure of monoacylglycerol lipase from Bacillus sp. H257 reveals unexpected conservation of the cap architecture between bacterial and human enzymes - Rengachari_2012_Biochim.Biophys.Acta_1821_1012
Author(s) : Rengachari S , Bezerra GA , Riegler-Berket L , Gruber CC , Sturm C , Taschler U , Boeszoermenyi A , Dreveny I , Zimmermann R , Gruber K , Oberer M
Ref : Biochimica & Biophysica Acta , 1821 :1012 , 2012
PubMedID: 22561231
Gene_locus related to this paper: bac25-mglp

Title : A novel thermostable carboxylesterase from Geobacillus thermodenitrificans: evidence for a new carboxylesterase family - Charbonneau_2010_J.Biochem_148_299
Author(s) : Charbonneau DM , Meddeb-Mouelhi F , Beauregard M
Ref : J Biochem , 148 :299 , 2010
PubMedID: 20587647
Gene_locus related to this paper: geotd-g3jwz2

Title : Molecular cloning and characterization of two thermostable carboxyl esterases from Geobacillus stearothermophilus - Ewis_2004_Gene_329_187
Author(s) : Ewis HE , Abdelal AT , Lu CD
Ref : Gene , 329 :187 , 2004
PubMedID: 15033540
Gene_locus related to this paper: geost-est30 , geost-est50

Title : Covalent reaction intermediate revealed in crystal structure of the Geobacillus stearothermophilus carboxylesterase Est30 - Liu_2004_J.Mol.Biol_342_551
Author(s) : Liu P , Wang YF , Ewis HE , Abdelal AT , Lu CD , Harrison RW , Weber IT
Ref : Journal of Molecular Biology , 342 :551 , 2004
PubMedID: 15327954
Gene_locus related to this paper: geost-est30

Title : Monoacylglycerol lipase from moderately thermophilic Bacillus sp. strain H-257: molecular cloning, sequencing, and expression in Escherichia coli of the gene - Kitaura_2001_J.Biochem_129_397
Author(s) : Kitaura S , Suzuki K , Imamura S
Ref : J Biochem , 129 :397 , 2001
PubMedID: 11226879
Gene_locus related to this paper: bac25-mglp

Title : Purification and characterization of a monoacylglycerol lipase from the moderately thermophilic Bacillus sp. H-257 - Imamura_2000_J.Biochem_127_419
Author(s) : Imamura S , Kitaura S
Ref : J Biochem , 127 :419 , 2000
PubMedID: 10731713
Gene_locus related to this paper: bac25-mglp

Title : Molecular cloning and structure of the gene for esterase from a thermophilic bacterium, Bacillus stearothermophilus IFO 12550 -
Author(s) : Kugimiya W , Otani Y , Hashimoto Y
Ref : Biosci Biotechnol Biochem , 56 :2074 , 1992
PubMedID: 1369099
Gene_locus related to this paper: geost-est30