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Inhibitor Report for: Fragment-283

Not inhibitor of Notum. Compound 25 Fragment 283 IC50 86+/-21 microM


General
Type Fragment inhibitor of Notum
Chemical_Nomenclature N-(4-anilinophenyl)acetamide
Canonical SMILES CC(=O)NC1=CC=C(C=C1)NC2=CC=CC=C2
InChI InChI=1S/C14H14N2O/c1-11(17)15-13-7-9-14(10-8-13)16-12-5-3-2-4-6-12/h2-10,16H,1H3,(H,15,17)
InChIKey QAIADKFUCPEVKW-UHFFFAOYSA-N
Other name(s) Fragment 283 ; compound 25 ; B1A ; N-[4-(phenylamino)phenyl]acetamide ; N-(4-anilinophenyl)acetamide ; 4'-(Anilino)acetoanilide ; 4-acetamido-N-phenylaniline ; Oprea1_324101 ; Oprea1_376523 ; SCHEMBL9480198 ; CHEMBL1543600 ; ZINC289523
________________________________________________________________________________________________
MW|226.27
Formula|C14H14N2O
CAS_number|38674-90-7
PubChem|789635
UniChem|QAIADKFUCPEVKW-UHFFFAOYSA-N
IUPHAR|
Wikipedia|

Target
Families | Fragment-283 ligand of proteins in family: Pectinacetylesterase-Notum
Stucture | 1 structure: 7B99: Structure of the Wnt deacylase Notum in complex with fragment 283
Protein | human-NOTUM

References:
Search PubMed for references concerning: Fragment-283
    Title: Structural Analysis and Development of Notum Fragment Screening Hits
    Zhao Y, Mahy W, Willis NJ, Woodward HL, Steadman D, Bayle ED, Atkinson BN, Sipthorp J, Vecchia L and Jones EY <11 more author(s)>
    Ref: ACS Chem Neurosci, 13:2060, 2022 : PubMed