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Inhibitor Report for: MBTFP

I50 = 9.4 mM from the fungal plant pathogen Monilinia fructicola affinity ligand


General
Type Trifluoro, Transition state analogue, Halo ketone, Sulfur Compound
Chemical_Nomenclature 1,1,1-trifluoro-3-(4-sulfanylbutylsulfanyl)propan-2-one
Canonical SMILES C(CCSCC(=O)C(F)(F)F)CS
InChI InChI=1S/C7H11F3OS2/c8-7(9,10)6(11)5-13-4-2-1-3-12/h12H,1-5H2
InChIKey CZLDICXWIYJWMC-UHFFFAOYSA-N
Other name(s) 1,1,1-Trifluoro-3-((4-mercaptobutyl)thio)-2-propanone ; 2-Propanone, 1,1,1-trifluoro-3-((4-mercaptobutyl)thio)- ; 3-((4'-Mercapto)butylthio)-1,1,1-trifluoropropan-2-one ; 3-(4-Mercaptobutylthio)-1,1,1-trifluoropropan-2-one
________________________________________________________________________________________________
MW|232.3
Formula|C7H11F3OS2
CAS_number|99541-29-4
PubChem|127358
UniChem|CZLDICXWIYJWMC-UHFFFAOYSA-N
IUPHAR|
Wikipedia|

Target
Families | MBTFP ligand of proteins in family: Cutinase, Juvenile_hormone_esterase
Protein | monfr-CUT1, manse-jhest

References:
Search PubMed for references concerning: MBTFP
    Title: Affinity purification and characterization of a cutinase from the fungal plant pathogen Monilinia fructicola (Wint.) honey
    Wang GY, Michailides TJ, Hammock BD, Lee YM, Bostock RM
    Ref: Archives of Biochemistry & Biophysics, 382:31, 2000 : PubMed

            

    Title: Characterization of affinity-purified juvenile hormone esterase from the plasma of the tobacco hornworm, Manduca sexta
    Venkatesh K, Abdel-Aal YA, Armstrong FB, Roe RM
    Ref: Journal of Biological Chemistry, 265:21727, 1990 : PubMed

            

    Title: Apparent multiple catalytic sites involved in the ester hydrolysis of juvenile hormones by the hemolymph and by an affinity-purified esterase from Manduca sexta Johannson (Lepidoptera: Sphingidae)
    Abdel-Aal YA, Hammock BD
    Ref: Archives of Biochemistry & Biophysics, 243:206, 1985 : PubMed