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Transition state analogue

General

Transition state analogs, are chemical compounds with a chemical structure that resembles the transition state of a substrate molecule in an enzyme-catalyzed chemical reaction and can bind more tightly to the enzyme than the actual substrate
Inhibitor Main targeted enzyme families Type Structure
(2R)-butane-2-sulfonate Haloperoxidase Transition state analogue Sulfur Compound
Dimethylarsinate Hormone-sensitive_lipase_like Transition state analogue
Phenylboronic-acid Cocaine_esterase Peptidase_S15 Transition state analogue Boron compound Dihydroxyphenyl
Zifrosilone ACHE Halo ketone Transition state analogue Trifluoro
FBQ ACHE Trifluoro Transition state analogue Quinoline Derivative of Tacrine Sulfur Compound
1-Chloro-3-phenoxy-2-propanone ACHE Halo ketone ketone Organochlorine Transition state analogue
1-phenoxypropanone ACHE ketone Transition state analogue
6-Dimethyl-3-difluoro-2-heptanone ACHE Halo ketone Transition state analogue Analogue of substrate
TAK-147 ACHE Piperidine Transition state analogue Benzazepin Benzylpiperidine Derivative of Donepezil
TBTFA ACHE BCHE Halo ketone Transition state analogue Trifluoro tert-Butyl
NAF ACHE Trifluoro Quaternary compound Trimethylammonium Ammonium Transition state analogue
MBTFP Cutinase Juvenile_hormone_esterase Trifluoro Transition state analogue Halo ketone Sulfur Compound
TMTFA ACHE Trifluoro Trimethylammonium Ammonium Quaternary compound Transition state analogue Halo ketone
(2R)-butane-2-sulfonate Haloperoxidase Transition state analogue Sulfur Compound
Dimethylarsinate Hormone-sensitive_lipase_like Transition state analogue
Phenylboronic-acid Cocaine_esterase Peptidase_S15 Transition state analogue Boron compound Dihydroxyphenyl
Zifrosilone ACHE Halo ketone Transition state analogue Trifluoro
FBQ ACHE Trifluoro Transition state analogue Quinoline Derivative of Tacrine Sulfur Compound
1-Chloro-3-phenoxy-2-propanone ACHE Halo ketone ketone Organochlorine Transition state analogue
1-phenoxypropanone ACHE ketone Transition state analogue
6-Dimethyl-3-difluoro-2-heptanone ACHE Halo ketone Transition state analogue Analogue of substrate
TAK-147 ACHE Piperidine Transition state analogue Benzazepin Benzylpiperidine Derivative of Donepezil
TBTFA ACHE BCHE Halo ketone Transition state analogue Trifluoro tert-Butyl
NAF ACHE Trifluoro Quaternary compound Trimethylammonium Ammonium Transition state analogue
MBTFP Cutinase Juvenile_hormone_esterase Trifluoro Transition state analogue Halo ketone Sulfur Compound
TMTFA ACHE Trifluoro Trimethylammonium Ammonium Quaternary compound Transition state analogue Halo ketone
(2R)-butane-2-sulfonate Haloperoxidase Transition state analogue Sulfur Compound
Dimethylarsinate Hormone-sensitive_lipase_like Transition state analogue
Phenylboronic-acid Cocaine_esterase Peptidase_S15 Transition state analogue Boron compound Dihydroxyphenyl
Zifrosilone ACHE Halo ketone Transition state analogue Trifluoro
FBQ ACHE Trifluoro Transition state analogue Quinoline Derivative of Tacrine Sulfur Compound
1-Chloro-3-phenoxy-2-propanone ACHE Halo ketone ketone Organochlorine Transition state analogue
1-phenoxypropanone ACHE ketone Transition state analogue
6-Dimethyl-3-difluoro-2-heptanone ACHE Halo ketone Transition state analogue Analogue of substrate
TAK-147 ACHE Piperidine Transition state analogue Benzazepin Benzylpiperidine Derivative of Donepezil
TBTFA ACHE BCHE Halo ketone Transition state analogue Trifluoro tert-Butyl
NAF ACHE Trifluoro Quaternary compound Trimethylammonium Ammonium Transition state analogue
MBTFP Cutinase Juvenile_hormone_esterase Trifluoro Transition state analogue Halo ketone Sulfur Compound
TMTFA ACHE Trifluoro Trimethylammonium Ammonium Quaternary compound Transition state analogue Halo ketone