El-Sayed_2005_Science_309_404

Reference

Title : Comparative genomics of trypanosomatid parasitic protozoa - El-Sayed_2005_Science_309_404
Author(s) : El-Sayed NM , Myler PJ , Blandin G , Berriman M , Crabtree J , Aggarwal G , Caler E , Renauld H , Worthey EA , Hertz-Fowler C , Ghedin E , Peacock C , Bartholomeu DC , Haas BJ , Tran AN , Wortman JR , Alsmark UC , Angiuoli S , Anupama A , Badger J , Bringaud F , Cadag E , Carlton JM , Cerqueira GC , Creasy T , Delcher AL , Djikeng A , Embley TM , Hauser C , Ivens AC , Kummerfeld SK , Pereira-Leal JB , Nilsson D , Peterson J , Salzberg SL , Shallom J , Silva JC , Sundaram J , Westenberger S , White O , Melville SE , Donelson JE , Andersson B , Stuart KD , Hall N
Ref : Science , 309 :404 , 2005
Abstract : A comparison of gene content and genome architecture of Trypanosoma brucei, Trypanosoma cruzi, and Leishmania major, three related pathogens with different life cycles and disease pathology, revealed a conserved core proteome of about 6200 genes in large syntenic polycistronic gene clusters. Many species-specific genes, especially large surface antigen families, occur at nonsyntenic chromosome-internal and subtelomeric regions. Retroelements, structural RNAs, and gene family expansion are often associated with syntenic discontinuities that-along with gene divergence, acquisition and loss, and rearrangement within the syntenic regions-have shaped the genomes of each parasite. Contrary to recent reports, our analyses reveal no evidence that these species are descended from an ancestor that contained a photosynthetic endosymbiont.
ESTHER : El-Sayed_2005_Science_309_404
PubMedSearch : El-Sayed_2005_Science_309_404
PubMedID: 16020724
Gene_locus related to this paper: tryb2-q382c1 , trycr-q4dhv2 , trycr-q4dpt2 , trycr-q4dpy4

Related information

Gene_locus related to this paper: tryb2-q382c1 , trycr-q4dhv2 , trycr-q4dpt2 , trycr-q4dpy4

Citations formats

El-Sayed NM, Myler PJ, Blandin G, Berriman M, Crabtree J, Aggarwal G, Caler E, Renauld H, Worthey EA, Hertz-Fowler C, Ghedin E, Peacock C, Bartholomeu DC, Haas BJ, Tran AN, Wortman JR, Alsmark UC, Angiuoli S, Anupama A, Badger J, Bringaud F, Cadag E, Carlton JM, Cerqueira GC, Creasy T, Delcher AL, Djikeng A, Embley TM, Hauser C, Ivens AC, Kummerfeld SK, Pereira-Leal JB, Nilsson D, Peterson J, Salzberg SL, Shallom J, Silva JC, Sundaram J, Westenberger S, White O, Melville SE, Donelson JE, Andersson B, Stuart KD, Hall N (2005)
Comparative genomics of trypanosomatid parasitic protozoa
Science 309 :404

El-Sayed NM, Myler PJ, Blandin G, Berriman M, Crabtree J, Aggarwal G, Caler E, Renauld H, Worthey EA, Hertz-Fowler C, Ghedin E, Peacock C, Bartholomeu DC, Haas BJ, Tran AN, Wortman JR, Alsmark UC, Angiuoli S, Anupama A, Badger J, Bringaud F, Cadag E, Carlton JM, Cerqueira GC, Creasy T, Delcher AL, Djikeng A, Embley TM, Hauser C, Ivens AC, Kummerfeld SK, Pereira-Leal JB, Nilsson D, Peterson J, Salzberg SL, Shallom J, Silva JC, Sundaram J, Westenberger S, White O, Melville SE, Donelson JE, Andersson B, Stuart KD, Hall N (2005)
Science 309 :404