Irie_1997_Science_277_1511

Reference

Title : Binding of neuroligins to PSD-95 - Irie_1997_Science_277_1511
Author(s) : Irie M , Hata Y , Takeuchi M , Ichtchenko K , Toyoda A , Hirao K , Takai Y , Rosahl TW , Sudhof TC
Ref : Science , 277 :1511 , 1997
Abstract : PSD-95 is a component of postsynaptic densities in central synapses. It contains three PDZ domains that localize N-methyl-D-aspartate receptor subunit 2 (NMDA2 receptor) and K+ channels to synapses. In mouse forebrain, PSD-95 bound to the cytoplasmic COOH-termini of neuroligins, which are neuronal cell adhesion molecules that interact with beta-neurexins and form intercellular junctions. Neuroligins bind to the third PDZ domain of PSD-95, whereas NMDA2 receptors and K+ channels interact with the first and second PDZ domains. Thus different PDZ domains of PSD-95 are specialized for distinct functions. PSD-95 may recruit ion channels and neurotransmitter receptors to intercellular junctions formed between neurons by neuroligins and beta-neurexins.
ESTHER : Irie_1997_Science_277_1511
PubMedSearch : Irie_1997_Science_277_1511
PubMedID: 9278515
Gene_locus related to this paper: human-NLGN1 , human-NLGN2 , human-NLGN3 , human-NLGN4X

Related information

Gene_locus related to this paper: human-NLGN1 , human-NLGN2 , human-NLGN3 , human-NLGN4X

Citations formats

Irie M, Hata Y, Takeuchi M, Ichtchenko K, Toyoda A, Hirao K, Takai Y, Rosahl TW, Sudhof TC (1997)
Binding of neuroligins to PSD-95
Science 277 :1511

Irie M, Hata Y, Takeuchi M, Ichtchenko K, Toyoda A, Hirao K, Takai Y, Rosahl TW, Sudhof TC (1997)
Science 277 :1511