human-NLGN2

Homo sapiens (Human) neuroligin 2 (KIAA1366)

Comment

Transmembrane scaffolding protein involved in cell-cell interactions via its interactions with neurexin family members. Mediates cell-cell interactions both in neurons and in other types of cells, such as Langerhans beta cells. Plays a role in synapse function and synaptic signal transmission, especially via gamma-aminobutyric acid receptors (GABA(A) receptors). Functions by recruiting and clustering synaptic proteins. Promotes clustering of postsynaptic GABRG2 and GPHN. Modulates signaling by inhibitory synapses, and thereby plays a role in controlling the ratio of signaling by excitatory and inhibitory synapses and information processing. Required for normal signal amplitude from inhibitory synapses, but is not essential for normal signal frequency. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. Mediates cell-cell interactions between Langerhans beta cells and modulates insulin secretion

Relationship

Family : Neuroligin

Block : C

Position in NCBI Life Tree : Homo sapiens

(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)

> cellular organisms N E > Eukaryota N E > Opisthokonta N E > Metazoa N E > Eumetazoa N E > Bilateria N E > Deuterostomia N E > Chordata N E > Craniata N E > Vertebrata N E > Gnathostomata N E > Teleostomi N E > Euteleostomi N E > Sarcopterygii N E > Dipnotetrapodomorpha N E > Tetrapoda N E > Amniota N E > Mammalia N E > Theria N E > Eutheria N E > Boreoeutheria N E > Euarchontoglires N E > Primates N E > Haplorrhini N E > Simiiformes N E > Catarrhini N E > Hominoidea N E > Hominidae N E > Homininae N E > Homo N E > Homo sapiens N E

Database

Sequence

Peptide

MWLLALCLVG LAGAQRGGGG PGGGAPGGPG LGLGSLGEER FPVVNTAYGR VRGVRRELNN EILGPVVQFL GVPYATPPLG ARRFQPPEAP ASWPGVRNAT TLPPACPQNL HGALPAIMLP VWFTDNLEAA ATYVQNQSED CLYLNLYVPT EDGPLTKKRD EATLNPPDTD IRDPGKKPVM LFLHGGSYME GTGNMFDGSV LAAYGNVIVA TLNYRLGVLG FLSTGDQAAK GNYGLLDQIQ ALRWLSENIA HFGGDPERIT IFGSGAGASC VNLLILSHHS EGLFQKAIAQ SGTAISSWSV NYQPLKYTRL LAAKVGCDRE DSAEAVECLR RKPSRELVDQ DVQPARYHIA FGPVVDGDVV PDDPEILMQQ GEFLNYDMLI GVNQGEGLKF VEDSAESEDG VSASAFDFTV SNFVDNLYGY PEGKDVLRET IKFMYTDWAD RDNGEMRRKT LLALFTDHQW VAPAVATAKL HADYQSPVYF YTFYHHCQAE GRPEWADAAH GDELPYVFGV PMVGATDLFP CNFSKNDVML SAVVMTYWTN FAKTGDPNQP VPQDTKFIHT KPNRFEEVVW SKFNSKEKQY LHIGLKPRVR DNYRANKVAF WLELVPHLHN LHTELFTTTT RLPPYATRWP PRPPAGAPGT RRPPPPATLP PEPEPEPGPR AYDRFPGDSR DYSTELSVTV AVGASLLFLN ILAFAALYYK RDRRQELRCR RLSPPGGSGS GVPGGGPLLP AAGRELPPEE ELVSLQLKRG GGVGADPAEA LRPACPPDYT LALRRAPDDV PLLAPGALTL LPSGLGPPPP PPPPSLHPFG PFPPPPPTAT SHNNTLPHPH STTRV

References (12)

Title : Neuroligin-2 shapes individual slow waves during slow-wave sleep and the response to sleep deprivation in mice - Leduc_2024_Mol.Autism_15_13
Author(s) : Leduc T , El Alami H , Bougadir K , Belanger-Nelson E , Mongrain V
Ref : Mol Autism , 15 :13 , 2024
PubMedID: 38570872
Gene_locus related to this paper: human-NLGN2 , mouse-2neur

Title : Expression and structural analysis of human neuroligin 2 and neuroligin 3 implicated in autism spectrum disorders - Zhang_2022_Front.Endocrinol.(Lausanne)_13_1067529
Author(s) : Zhang Z , Hou M , Ou H , Wang D , Li Z , Zhang H , Lu J
Ref : Front Endocrinol (Lausanne) , 13 :1067529 , 2022
PubMedID: 36479216
Gene_locus related to this paper: human-NLGN2 , human-NLGN3

Title : GABAergic deficits and schizophrenia-like behaviors in a mouse model carrying patient-derived neuroligin-2 R215H mutation - Jiang_2018_Mol.Brain_11_31
Author(s) : Jiang DY , Wu Z , Forsyth CT , Hu Y , Yee SP , Chen G
Ref : Mol Brain , 11 :31 , 2018
PubMedID: 29859117
Gene_locus related to this paper: human-NLGN2

Title : Structural Insights into Modulation of Neurexin-Neuroligin Trans-synaptic Adhesion by MDGA1\/Neuroligin-2 Complex - Kim_2017_Neuron_94_1121
Author(s) : Kim JA , Kim D , Won SY , Han KA , Park D , Cho E , Yun N , An HJ , Um JW , Kim E , Lee JO , Ko J , Kim HM
Ref : Neuron , 94 :1121 , 2017
PubMedID: 28641111
Gene_locus related to this paper: human-NLGN2

Title : Neuroligin 2 R215H Mutant Mice Manifest Anxiety, Increased Prepulse Inhibition, and Impaired Spatial Learning and Memory - Chen_2017_Front.Psychiatry_8_257
Author(s) : Chen CH , Lee PW , Liao HM , Chang PK
Ref : Front Psychiatry , 8 :257 , 2017
PubMedID: 29230184
Gene_locus related to this paper: human-NLGN2 , mouse-2neur

Title : Neuroligin 2 nonsense variant associated with anxiety, autism, intellectual disability, hyperphagia, and obesity - Parente_2017_Am.J.Med.Genet.A_173_213
Author(s) : Parente DJ , Garriga C , Baskin B , Douglas G , Cho MT , Araujo GC , Shinawi M
Ref : American Journal of Medicine Genet A , 173 :213 , 2017
PubMedID: 27865048
Gene_locus related to this paper: human-NLGN2

Title : Identification and functional characterization of rare mutations of the neuroligin-2 gene (NLGN2) associated with schizophrenia - Sun_2011_Hum.Mol.Genet_20_3042
Author(s) : Sun C , Cheng MC , Qin R , Liao DL , Chen TT , Koong FJ , Chen G , Chen CH
Ref : Hum Mol Genet , 20 :3042 , 2011
PubMedID: 21551456
Gene_locus related to this paper: human-NLGN2

Title : Mutations of the X-linked genes encoding neuroligins NLGN3 and NLGN4 are associated with autism - Jamain_2003_Nat.Genet_34_27
Author(s) : Jamain S , Quach H , Betancur C , Rastam M , Colineaux C , Gillberg IC , Soderstrom H , Giros B , Leboyer M , Gillberg C , Bourgeron T
Ref : Nat Genet , 34 :27 , 2003
PubMedID: 12669065
Gene_locus related to this paper: human-NLGN2 , human-NLGN4X , human-NLGN4Y , mouse-4neur , human-NLGN3

Title : Neuroligin expressed in nonneuronal cells triggers presynaptic development in contacting axons - Scheiffele_2000_Cell_101_657
Author(s) : Scheiffele P , Fan J , Choih J , Fetter R , Serafini T
Ref : Cell , 101 :657 , 2000
PubMedID: 10892652
Gene_locus related to this paper: human-NLGN1 , human-NLGN2

Title : Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro - Nagase_2000_DNA.Res_7_65
Author(s) : Nagase T , Kikuno R , Ishikawa KI , Hirosawa M , Ohara O
Ref : DNA Research , 7 :65 , 2000
PubMedID: 10718198
Gene_locus related to this paper: human-FAM135A , human-KANSL3 , human-NCEH1 , human-NLGN2

Title : Binding of neuroligins to PSD-95 - Irie_1997_Science_277_1511
Author(s) : Irie M , Hata Y , Takeuchi M , Ichtchenko K , Toyoda A , Hirao K , Takai Y , Rosahl TW , Sudhof TC
Ref : Science , 277 :1511 , 1997
PubMedID: 9278515
Gene_locus related to this paper: human-NLGN1 , human-NLGN2 , human-NLGN3 , human-NLGN4X