human-NLGN2
Homo sapiens (Human) neuroligin 2 (KIAA1366)
Comment
Transmembrane scaffolding protein involved in cell-cell interactions via its interactions with neurexin family members. Mediates cell-cell interactions both in neurons and in other types of cells, such as Langerhans beta cells. Plays a role in synapse function and synaptic signal transmission, especially via gamma-aminobutyric acid receptors (GABA(A) receptors). Functions by recruiting and clustering synaptic proteins. Promotes clustering of postsynaptic GABRG2 and GPHN. Modulates signaling by inhibitory synapses, and thereby plays a role in controlling the ratio of signaling by excitatory and inhibitory synapses and information processing. Required for normal signal amplitude from inhibitory synapses, but is not essential for normal signal frequency. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. Mediates cell-cell interactions between Langerhans beta cells and modulates insulin secretion
Relationship
Family : Neuroligin
Block : C
Position in NCBI Life Tree : Homo sapiens
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)
> cellular organisms N E > Eukaryota N E > Opisthokonta N E > Metazoa N E > Eumetazoa N E > Bilateria N E > Deuterostomia N E > Chordata N E > Craniata N E > Vertebrata N E > Gnathostomata N E > Teleostomi N E > Euteleostomi N E > Sarcopterygii N E > Dipnotetrapodomorpha N E > Tetrapoda N E > Amniota N E > Mammalia N E > Theria N E > Eutheria N E > Boreoeutheria N E > Euarchontoglires N E > Primates N E > Haplorrhini N E > Simiiformes N E > Catarrhini N E > Hominoidea N E > Hominidae N E > Homininae N E > Homo N E > Homo sapiens N EMolecular evidence
Sequence
Peptide
MWLLALCLVG LAGAQRGGGG PGGGAPGGPG LGLGSLGEER FPVVNTAYGR VRGVRRELNN EILGPVVQFL GVPYATPPLG ARRFQPPEAP ASWPGVRNAT TLPPACPQNL HGALPAIMLP VWFTDNLEAA ATYVQNQSED CLYLNLYVPT EDGPLTKKRD EATLNPPDTD IRDPGKKPVM LFLHGGSYME GTGNMFDGSV LAAYGNVIVA TLNYRLGVLG FLSTGDQAAK GNYGLLDQIQ ALRWLSENIA HFGGDPERIT IFGSGAGASC VNLLILSHHS EGLFQKAIAQ SGTAISSWSV NYQPLKYTRL LAAKVGCDRE DSAEAVECLR RKPSRELVDQ DVQPARYHIA FGPVVDGDVV PDDPEILMQQ GEFLNYDMLI GVNQGEGLKF VEDSAESEDG VSASAFDFTV SNFVDNLYGY PEGKDVLRET IKFMYTDWAD RDNGEMRRKT LLALFTDHQW VAPAVATAKL HADYQSPVYF YTFYHHCQAE GRPEWADAAH GDELPYVFGV PMVGATDLFP CNFSKNDVML SAVVMTYWTN FAKTGDPNQP VPQDTKFIHT KPNRFEEVVW SKFNSKEKQY LHIGLKPRVR DNYRANKVAF WLELVPHLHN LHTELFTTTT RLPPYATRWP PRPPAGAPGT RRPPPPATLP PEPEPEPGPR AYDRFPGDSR DYSTELSVTV AVGASLLFLN ILAFAALYYK RDRRQELRCR RLSPPGGSGS GVPGGGPLLP AAGRELPPEE ELVSLQLKRG GGVGADPAEA LRPACPPDYT LALRRAPDDV PLLAPGALTL LPSGLGPPPP PPPPSLHPFG PFPPPPPTAT SHNNTLPHPH STTRV
References (13)
| Title : Neuroligin-2 shapes individual slow waves during slow-wave sleep and the response to sleep deprivation in mice - Leduc_2024_Mol.Autism_15_13 |
| Author(s) : Leduc T , El Alami H , Bougadir K , Belanger-Nelson E , Mongrain V |
| Ref : Mol Autism , 15 :13 , 2024 |
| Abstract : |
| PubMedSearch : Leduc_2024_Mol.Autism_15_13 |
| PubMedID: 38570872 |
| Gene_locus related to this paper: human-NLGN2 , mouse-2neur |
| Title : Functional Neuroligin-2-MDGA1 interactions differentially regulate synaptic GABA(A)Rs and cytosolic gephyrin aggregation - Zeppillo_2024_Commun.Biol_7_1157 |
| Author(s) : Zeppillo T , Ali H , Ravichandran S , Ritter TC , Wenger S , Lopez-Murcia FJ , Gideons E , Signorelli J , Schmeisser MJ , Wiltfang J , Rhee J , Brose N , Taschenberger H , Krueger-Burg D |
| Ref : Commun Biol , 7 :1157 , 2024 |
| Abstract : |
| PubMedSearch : Zeppillo_2024_Commun.Biol_7_1157 |
| PubMedID: 39284869 |
| Gene_locus related to this paper: human-NLGN2 , mouse-2neur |
| Title : Expression and structural analysis of human neuroligin 2 and neuroligin 3 implicated in autism spectrum disorders - Zhang_2022_Front.Endocrinol.(Lausanne)_13_1067529 |
| Author(s) : Zhang Z , Hou M , Ou H , Wang D , Li Z , Zhang H , Lu J |
| Ref : Front Endocrinol (Lausanne) , 13 :1067529 , 2022 |
| Abstract : |
| PubMedSearch : Zhang_2022_Front.Endocrinol.(Lausanne)_13_1067529 |
| PubMedID: 36479216 |
| Gene_locus related to this paper: human-NLGN2 , human-NLGN3 |
| Title : GABAergic deficits and schizophrenia-like behaviors in a mouse model carrying patient-derived neuroligin-2 R215H mutation - Jiang_2018_Mol.Brain_11_31 |
| Author(s) : Jiang DY , Wu Z , Forsyth CT , Hu Y , Yee SP , Chen G |
| Ref : Mol Brain , 11 :31 , 2018 |
| Abstract : |
| PubMedSearch : Jiang_2018_Mol.Brain_11_31 |
| PubMedID: 29859117 |
| Gene_locus related to this paper: human-NLGN2 |
| Title : Neuroligin 2 R215H Mutant Mice Manifest Anxiety, Increased Prepulse Inhibition, and Impaired Spatial Learning and Memory - Chen_2017_Front.Psychiatry_8_257 |
| Author(s) : Chen CH , Lee PW , Liao HM , Chang PK |
| Ref : Front Psychiatry , 8 :257 , 2017 |
| Abstract : |
| PubMedSearch : Chen_2017_Front.Psychiatry_8_257 |
| PubMedID: 29230184 |
| Gene_locus related to this paper: human-NLGN2 , mouse-2neur |
| Title : Structural Insights into Modulation of Neurexin-Neuroligin Trans-synaptic Adhesion by MDGA1\/Neuroligin-2 Complex - Kim_2017_Neuron_94_1121 |
| Author(s) : Kim JA , Kim D , Won SY , Han KA , Park D , Cho E , Yun N , An HJ , Um JW , Kim E , Lee JO , Ko J , Kim HM |
| Ref : Neuron , 94 :1121 , 2017 |
| Abstract : |
| PubMedSearch : Kim_2017_Neuron_94_1121 |
| PubMedID: 28641111 |
| Gene_locus related to this paper: human-NLGN2 |
| Title : Neuroligin 2 nonsense variant associated with anxiety, autism, intellectual disability, hyperphagia, and obesity - Parente_2017_Am.J.Med.Genet.A_173_213 |
| Author(s) : Parente DJ , Garriga C , Baskin B , Douglas G , Cho MT , Araujo GC , Shinawi M |
| Ref : American Journal of Medicine Genet A , 173 :213 , 2017 |
| Abstract : |
| PubMedSearch : Parente_2017_Am.J.Med.Genet.A_173_213 |
| PubMedID: 27865048 |
| Gene_locus related to this paper: human-NLGN2 |
| Title : Identification and functional characterization of rare mutations of the neuroligin-2 gene (NLGN2) associated with schizophrenia - Sun_2011_Hum.Mol.Genet_20_3042 |
| Author(s) : Sun C , Cheng MC , Qin R , Liao DL , Chen TT , Koong FJ , Chen G , Chen CH |
| Ref : Hum Mol Genet , 20 :3042 , 2011 |
| Abstract : |
| PubMedSearch : Sun_2011_Hum.Mol.Genet_20_3042 |
| PubMedID: 21551456 |
| Gene_locus related to this paper: human-NLGN2 |
| Title : Mutations of the X-linked genes encoding neuroligins NLGN3 and NLGN4 are associated with autism - Jamain_2003_Nat.Genet_34_27 |
| Author(s) : Jamain S , Quach H , Betancur C , Rastam M , Colineaux C , Gillberg IC , Soderstrom H , Giros B , Leboyer M , Gillberg C , Bourgeron T |
| Ref : Nat Genet , 34 :27 , 2003 |
| Abstract : |
| PubMedSearch : Jamain_2003_Nat.Genet_34_27 |
| PubMedID: 12669065 |
| Gene_locus related to this paper: human-NLGN2 , human-NLGN4X , human-NLGN4Y , mouse-4neur , human-NLGN3 |
| Title : Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro - Nagase_2000_DNA.Res_7_65 |
| Author(s) : Nagase T , Kikuno R , Ishikawa KI , Hirosawa M , Ohara O |
| Ref : DNA Research , 7 :65 , 2000 |
| Abstract : |
| PubMedSearch : Nagase_2000_DNA.Res_7_65 |
| PubMedID: 10718198 |
| Gene_locus related to this paper: human-FAM135A , human-KANSL3 , human-NCEH1 , human-NLGN2 |
| Title : Neuroligin expressed in nonneuronal cells triggers presynaptic development in contacting axons - Scheiffele_2000_Cell_101_657 |
| Author(s) : Scheiffele P , Fan J , Choih J , Fetter R , Serafini T |
| Ref : Cell , 101 :657 , 2000 |
| Abstract : |
| PubMedSearch : Scheiffele_2000_Cell_101_657 |
| PubMedID: 10892652 |
| Gene_locus related to this paper: human-NLGN1 , human-NLGN2 |
| Title : Binding of neuroligins to PSD-95 - Irie_1997_Science_277_1511 |
| Author(s) : Irie M , Hata Y , Takeuchi M , Ichtchenko K , Toyoda A , Hirao K , Takai Y , Rosahl TW , Sudhof TC |
| Ref : Science , 277 :1511 , 1997 |
| Abstract : |
| PubMedSearch : Irie_1997_Science_277_1511 |
| PubMedID: 9278515 |
| Gene_locus related to this paper: human-NLGN1 , human-NLGN2 , human-NLGN3 , human-NLGN4X |