Stajich_2010_Proc.Natl.Acad.Sci.U.S.A_107_11889

Reference

Title : Insights into evolution of multicellular fungi from the assembled chromosomes of the mushroom Coprinopsis cinerea (Coprinus cinereus) - Stajich_2010_Proc.Natl.Acad.Sci.U.S.A_107_11889
Author(s) : Stajich JE , Wilke SK , Ahren D , Au CH , Birren BW , Borodovsky M , Burns C , Canback B , Casselton LA , Cheng CK , Deng J , Dietrich FS , Fargo DC , Farman ML , Gathman AC , Goldberg J , Guigo R , Hoegger PJ , Hooker JB , Huggins A , James TY , Kamada T , Kilaru S , Kodira C , Kues U , Kupfer D , Kwan HS , Lomsadze A , Li W , Lilly WW , Ma LJ , Mackey AJ , Manning G , Martin F , Muraguchi H , Natvig DO , Palmerini H , Ramesh MA , Rehmeyer CJ , Roe BA , Shenoy N , Stanke M , Ter-Hovhannisyan V , Tunlid A , Velagapudi R , Vision TJ , Zeng Q , Zolan ME , Pukkila PJ
Ref : Proc Natl Acad Sci U S A , 107 :11889 , 2010
Abstract :

The mushroom Coprinopsis cinerea is a classic experimental model for multicellular development in fungi because it grows on defined media, completes its life cycle in 2 weeks, produces some 10(8) synchronized meiocytes, and can be manipulated at all stages in development by mutation and transformation. The 37-megabase genome of C. cinerea was sequenced and assembled into 13 chromosomes. Meiotic recombination rates vary greatly along the chromosomes, and retrotransposons are absent in large regions of the genome with low levels of meiotic recombination. Single-copy genes with identifiable orthologs in other basidiomycetes are predominant in low-recombination regions of the chromosome. In contrast, paralogous multicopy genes are found in the highly recombining regions, including a large family of protein kinases (FunK1) unique to multicellular fungi. Analyses of P450 and hydrophobin gene families confirmed that local gene duplications drive the expansions of paralogous copies and the expansions occur in independent lineages of Agaricomycotina fungi. Gene-expression patterns from microarrays were used to dissect the transcriptional program of dikaryon formation (mating). Several members of the FunK1 kinase family are differentially regulated during sexual morphogenesis, and coordinate regulation of adjacent duplications is rare. The genomes of C. cinerea and Laccaria bicolor, a symbiotic basidiomycete, share extensive regions of synteny. The largest syntenic blocks occur in regions with low meiotic recombination rates, no transposable elements, and tight gene spacing, where orthologous single-copy genes are overrepresented. The chromosome assembly of C. cinerea is an essential resource in understanding the evolution of multicellularity in the fungi.

PubMedSearch : Stajich_2010_Proc.Natl.Acad.Sci.U.S.A_107_11889
PubMedID: 20547848
Gene_locus related to this paper: copc7-a8n2b8 , copc7-a8n3e0 , copc7-a8n3e1 , copc7-a8n6a5 , copc7-a8n8h4 , copc7-a8n702 , copc7-a8n941 , copc7-a8nkc7 , copc7-a8nll5 , copc7-a8nll6 , copc7-a8nqf4 , copc7-a8nqg3 , copc7-a8nqv8 , copc7-a8nvb5 , copc7-a8nwm2 , copc7-a8nz18 , copc7-a8p0p4 , copc7-d6rlx1 , copc7-d6rnh7 , copc7-kex1 , copci-b9u444 , copc7-a8nb05 , copc7-a8nha0 , copci-b9u443 , copc7-a8nq30 , copc7-a8nh79 , copc7-d6rm78 , copc7-a8nzs7 , copc7-axe1

Related information

Gene_locus copc7-a8n2b8    copc7-a8n3e0    copc7-a8n3e1    copc7-a8n6a5    copc7-a8n8h4    copc7-a8n702    copc7-a8n941    copc7-a8nkc7    copc7-a8nll5    copc7-a8nll6    copc7-a8nqf4    copc7-a8nqg3    copc7-a8nqv8    copc7-a8nvb5    copc7-a8nwm2    copc7-a8nz18    copc7-a8p0p4    copc7-d6rlx1    copc7-d6rnh7    copc7-kex1    copci-b9u444    copc7-a8nb05    copc7-a8nha0    copci-b9u443    copc7-a8nq30    copc7-a8nh79    copc7-d6rm78    copc7-a8nzs7    copc7-axe1
Gene_locus_frgt copc7-a8n2b8    copc7-a8n3e0    copc7-a8n3e1    copc7-a8n6a5    copc7-a8n8h4    copc7-a8n702    copc7-a8n941    copc7-a8nkc7    copc7-a8nll5    copc7-a8nll6    copc7-a8nqf4    copc7-a8nqg3    copc7-a8nqv8    copc7-a8nvb5    copc7-a8nwm2    copc7-a8nz18    copc7-a8p0p4    copc7-d6rlx1    copc7-d6rnh7    copc7-kex1    copci-b9u444    copc7-a8nb05    copc7-a8nha0    copci-b9u443    copc7-a8nq30    copc7-a8nh79    copc7-d6rm78    copc7-a8nzs7    copc7-axe1    copc7-a8nfh7    copc7-d6rpq0

Citations formats

Stajich JE, Wilke SK, Ahren D, Au CH, Birren BW, Borodovsky M, Burns C, Canback B, Casselton LA, Cheng CK, Deng J, Dietrich FS, Fargo DC, Farman ML, Gathman AC, Goldberg J, Guigo R, Hoegger PJ, Hooker JB, Huggins A, James TY, Kamada T, Kilaru S, Kodira C, Kues U, Kupfer D, Kwan HS, Lomsadze A, Li W, Lilly WW, Ma LJ, Mackey AJ, Manning G, Martin F, Muraguchi H, Natvig DO, Palmerini H, Ramesh MA, Rehmeyer CJ, Roe BA, Shenoy N, Stanke M, Ter-Hovhannisyan V, Tunlid A, Velagapudi R, Vision TJ, Zeng Q, Zolan ME, Pukkila PJ (2010)
Insights into evolution of multicellular fungi from the assembled chromosomes of the mushroom Coprinopsis cinerea (Coprinus cinereus)
Proc Natl Acad Sci U S A 107 :11889

Stajich JE, Wilke SK, Ahren D, Au CH, Birren BW, Borodovsky M, Burns C, Canback B, Casselton LA, Cheng CK, Deng J, Dietrich FS, Fargo DC, Farman ML, Gathman AC, Goldberg J, Guigo R, Hoegger PJ, Hooker JB, Huggins A, James TY, Kamada T, Kilaru S, Kodira C, Kues U, Kupfer D, Kwan HS, Lomsadze A, Li W, Lilly WW, Ma LJ, Mackey AJ, Manning G, Martin F, Muraguchi H, Natvig DO, Palmerini H, Ramesh MA, Rehmeyer CJ, Roe BA, Shenoy N, Stanke M, Ter-Hovhannisyan V, Tunlid A, Velagapudi R, Vision TJ, Zeng Q, Zolan ME, Pukkila PJ (2010)
Proc Natl Acad Sci U S A 107 :11889