GM508
General
Type : Oxime, Pyridine-aldoxime, Isoquinoline
Chemical_Nomenclature : 6-(5-(1-(4-(Dimethylamino)phenyl)-6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)pentyl)-3-hydroxypicolinaldehyde oxime
Canonical SMILES : C1(=C(N=C(C=C1)CCCCCN2C(C3=C(CC2)C=C(C(=C3)OC)OC)C4=CC=C(C=C4)N(C)C)C=NO)O
InChI : InChI=1S\/C30H38N4O4\/c1-33(2)24-12-9-21(10-13-24)30-25-19-29(38-4)28(37-3)18-22(25)15-17-34(30)16-7-5-6-8-23-11-14-27(35)26(32-23)20-31-36\/h9-14,18-20,30,35-36H,5-8,15-17H2,1-4H3
InChIKey : ZTBJJQOFAUNMBC-UHFFFAOYSA-N
Other name(s) :
Target
Structure : No structure
Families : No family
References (2)
| Title : Pharmacokinetic evaluation of brain penetrating morpholine-3-hydroxy-2-pyridine oxime as an antidote for nerve agent poisoning - Zorbaz_2020_ACS.Chem.Neurosci__ |
| Author(s) : Zorbaz T , Misetic P , Probst N , Zunec S , Zandona A , Mendas G , Micek V , Macek Hrvat N , Katalinic M , Braiki A , Jean L , Renard PY , Gabelica Markovic V , Kovarik Z |
| Ref : ACS Chem Neurosci , : , 2020 |
| Abstract : |
| PubMedSearch : Zorbaz_2020_ACS.Chem.Neurosci__ |
| PubMedID: 32105443 |
| Title : An easy method for the determination of active concentrations of cholinesterase reactivators in blood samples: Application to the efficacy assessment of non quaternary reactivators compared to HI-6 and pralidoxime in VX-poisoned mice - Calas_2017_Chem.Biol.Interact_267_11 |
| Author(s) : Calas AG , Dias J , Rousseau C , Arboleas M , Touvrey-Loiodice M , Mercey G , Jean L , Renard PY , Nachon F |
| Ref : Chemico-Biological Interactions , 267 :11 , 2017 |
| Abstract : |
| PubMedSearch : Calas_2017_Chem.Biol.Interact_267_11 |
| PubMedID: 26972668 |