Name : Crystal Structure of Human Liver Carboxylesterase 1 (hCE1) in covalent complex with the nerve agent Cyclosarin (GF)

Revelation date : 19-Jan-2010

Family : Carb_B_Chordata

Gene_locus : human-CES1

PDB file : ESTHER: header of PDB entry RCSB: Full entry

Hemmert, A.C., Otto, T.C., Weirdl, M., Potter, P.M., Cerasoli, D.M., Redinbo, M.R.

Ligand : Inhibitor Cyclosarin Ligand in structure: Ligplot

References (1)

Title : Human carboxylesterase 1 stereoselectively binds the nerve agent cyclosarin and spontaneously hydrolyzes the nerve agent sarin - Hemmert_2010_Mol.Pharmacol_77_508
Author(s) : Hemmert AC , Otto TC , Wierdl M , Edwards CC , Fleming CD , MacDonald M , Cashman JR , Potter PM , Cerasoli DM , Redinbo MR
Ref : Molecular Pharmacology , 77 :508 , 2010
Abstract :
PubMedSearch : Hemmert_2010_Mol.Pharmacol_77_508
PubMedID: 20051531
Gene_locus related to this paper: human-CES1

Representative scheme of Prolylcarboxypeptidase structure and an image from PDBsum server


PDB-Sum : 3K9B Previously Class, Architecture, Topology and Homologous superfamily - PDB-Sum server

FSSP : 3K9B Fold classification based on Structure-Structure alignment of Proteins - FSSP server

SCOP : 3K9B Structural Classification Of Protein - SCOP server

PROTEOPEDIA : 3K9B 3D, interactive encyclopedia of proteins - PROTEOPEDIA server