Otto TC

General

Full name : Otto Tamara C

First name : Tamara C

Mail : U.S. Army Medical Institute of Chemical Defense\; Analytical Toxicology\; 3100 Ricketts Point Rd\; Aberdeen Proving Ground\; 21010

Zip Code :

City :

Country : USA

Email : tamara.c.otto.civ@mail.mil

Phone : +1114104368687

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Website :

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References (15)

Title : Computational Design of Phosphotriesterase Improves V-Agent Degradation Efficiency - Kronenberg_2024_ChemistryOpen__e202300263
Author(s) : Kronenberg J , Chu S , Olsen A , Britton D , Halvorsen L , Guo S , Lakshmi A , Chen J , Kulapurathazhe MJ , Baker CA , Wadsworth BC , Van Acker CJ , Lehman JG, 3rd , Otto TC , Renfrew PD , Bonneau R , Montclare JK
Ref : ChemistryOpen , :e202300263 , 2024
PubMedID: 38426687

Title : Butyrylcholinesterase, a stereospecific in vivo bioscavenger against nerve agent intoxication - Cerasoli_2019_Biochem.Pharmacol__113670
Author(s) : Cerasoli DM , Armstrong SJ , Reeves TE , Hodgins SM , Kasten SA , Lee-Stubbs RB , Cadieux CL , Otto TC , Capacio BR , Lenz DE
Ref : Biochemical Pharmacology , :113670 , 2019
PubMedID: 31628910

Title : Use of V Agents and V-Analogue Compounds to Probe the Active Site of Atypical Butyrylcholinesterase from Oryzias latipes - Kirkpatrick_2016_Chem.Biol.Interact_259_182
Author(s) : Kirkpatrick MG , diTargiani RC , Sweeney RE , Otto TC
Ref : Chemico-Biological Interactions , 259 :182 , 2016
PubMedID: 27000540

Title : Assessing protection against OP pesticides and nerve agents provided by wild-type HuPON1 purified from Trichoplusia ni larvae or induced via adenoviral infection - Hodgins_2013_Chem.Biol.Interact_203_177
Author(s) : Hodgins SM , Kasten SA , Harrison J , Otto TC , Oliver ZP , Rezk P , Reeves TE , Chilukuri N , Cerasoli DM
Ref : Chemico-Biological Interactions , 203 :177 , 2013
PubMedID: 23123254

Title : Identification and characterization of novel catalytic bioscavengers of organophosphorus nerve agents - Otto_2013_Chem.Biol.Interact_203_186
Author(s) : Otto TC , Scott JR , Kauffman MA , Hodgins SM , diTargiani RC , Hughes JH , Sarricks EP , Saturday GA , Hamilton TA , Cerasoli DM
Ref : Chemico-Biological Interactions , 203 :186 , 2013
PubMedID: 23041042

Title : Solubilization and humanization of paraoxonase-1 - Sarkar_2012_J.Lipids_2012_610937
Author(s) : Sarkar M , Harsch CK , Matic GT , Hoffman K , Norris JR, 3rd , Otto TC , Lenz DE , Cerasoli DM , Magliery TJ
Ref : J Lipids , 2012 :610937 , 2012
PubMedID: 22720164

Title : Structure of Recombinant Human Carboxylesterase 1 Isolated from Whole Cabbage Looper Larvae - Greenblatt_2012_Acta.Crystallogr.Sect.F.Struct.Biol.Cryst.Commun_F68_269
Author(s) : Greenblatt HM , Otto TC , Kirkpatrick MG , Kovaleva E , Brown S , Buchman G , Cerasoli DM , Sussman JL
Ref : Acta Crystallographica Sect F Struct Biol Cryst Commun , F68 :269 , 2012
PubMedID: 22442219
Gene_locus related to this paper: human-CES1

Title : VX hydrolysis by human serum paraoxonase 1: a comparison of experimental and computational results - Peterson_2011_PLoS.One_6_e20335
Author(s) : Peterson MW , Fairchild SZ , Otto TC , Mohtashemi M , Cerasoli DM , Chang WE
Ref : PLoS ONE , 6 :e20335 , 2011
PubMedID: 21655255

Title : Nerve agent hydrolysis activity designed into a human drug metabolism enzyme - Hemmert_2011_PLoS.One_6_e17441
Author(s) : Hemmert AC , Otto TC , Chica RA , Wierdl M , Edwards JS , Lewis SM , Edwards CC , Tsurkan L , Cadieux CL , Kasten SA , Cashman JR , Mayo SL , Potter PM , Cerasoli DM , Redinbo MR
Ref : PLoS ONE , 6 :e17441 , 2011
PubMedID: 21445272
Gene_locus related to this paper: human-CES1

Title : Plant-derived human butyrylcholinesterase, but not an organophosphorous-compound hydrolyzing variant thereof, protects rodents against nerve agents - Geyer_2010_Proc.Natl.Acad.Sci.U.S.A_107_20251
Author(s) : Geyer BC , Kannan L , Garnaud PE , Broomfield CA , Cadieux CL , Cherni I , Hodgins SM , Kasten SA , Kelley K , Kilbourne J , Oliver ZP , Otto TC , Puffenberger I , Reeves TE , Robbins N, 2nd , Woods RR , Soreq H , Lenz DE , Cerasoli DM , Mor TS
Ref : Proc Natl Acad Sci U S A , 107 :20251 , 2010
PubMedID: 21059932

Title : Purification and characterization of functional human paraoxonase-1 expressed in Trichoplusia ni larvae - Otto_2010_Chem.Biol.Interact_187_388
Author(s) : Otto TC , Kasten SA , Kovaleva E , Liu Z , Buchman G , Tolosa M , Davis D , Smith JR , Balcerzak R , Lenz DE , Cerasoli DM
Ref : Chemico-Biological Interactions , 187 :388 , 2010
PubMedID: 20176005

Title : Computational Modeling of Human Paraoxonase 1: Preparation of Protein Models, Binding Studies, and Mechanistic Insights - Sanan_2010_J.Phys.Org.Chem_23_357
Author(s) : Sanan TT , Muthukrishnan S , Beck JM , Tao P , Hayes CJ , Otto TC , Cerasoli DM , Lenz DE , Hadad CM
Ref : J Phys Org Chem , 23 :357 , 2010
PubMedID: 24077808

Title : Human carboxylesterase 1 stereoselectively binds the nerve agent cyclosarin and spontaneously hydrolyzes the nerve agent sarin - Hemmert_2010_Mol.Pharmacol_77_508
Author(s) : Hemmert AC , Otto TC , Wierdl M , Edwards CC , Fleming CD , MacDonald M , Cashman JR , Potter PM , Cerasoli DM , Redinbo MR
Ref : Molecular Pharmacology , 77 :508 , 2010
PubMedID: 20051531
Gene_locus related to this paper: human-CES1

Title : Engineering human PON1 in an E. coli expression system - Suzuki_2010_Adv.Exp.Med.Biol_660_37
Author(s) : Suzuki SM , Stevens RC , Richter RJ , Cole TB , Park S , Otto TC , Cerasoli DM , Lenz DE , Furlong CE
Ref : Advances in Experimental Medicine & Biology , 660 :37 , 2010
PubMedID: 20221869

Title : Dramatic differences in organophosphorus hydrolase activity between human and chimeric recombinant mammalian paraoxonase-1 enzymes - Otto_2009_Biochemistry_48_10416
Author(s) : Otto TC , Harsch CK , Yeung DT , Magliery TJ , Cerasoli DM , Lenz DE
Ref : Biochemistry , 48 :10416 , 2009
PubMedID: 19764813