6BQ0
Name : Structure of human monoacylglycerol lipase bound to PF-06795071 a covalent inhibitor
Revelation date : 14-Mar-2018
Family : Monoglyceridelipase_lysophospholip
Gene_locus : human-MGLL
PDB file : ESTHER: header of PDB entry RCSB: Full entry
Comment
Pandit, J.
Ligand : Inhibitor PF-06795071 Ligand in structure: Ligplot
References (3)
| Title : Discovery of Trifluoromethyl Glycol Carbamates as Potent and Selective Covalent Monoacylglycerol Lipase (MAGL) Inhibitors for Treatment of Neuroinflammation - McAllister_2018_J.Med.Chem_61_3008 |
| Author(s) : McAllister LA , Butler CR , Mente S , O'Neil SV , Fonseca KR , Piro JR , Cianfrogna JA , Foley TL , Gilbert AM , Harris AR , Helal CJ , Johnson DS , Montgomery JI , Nason DM , Noell S , Pandit J , Rogers BN , Samad TA , Shaffer CL , da Silva RG , Uccello DP , Webb D , Brodney MA |
| Ref : Journal of Medicinal Chemistry , 61 :3008 , 2018 |
| Abstract : |
| PubMedSearch : McAllister_2018_J.Med.Chem_61_3008 |
| PubMedID: 29498843 |
| Gene_locus related to this paper: human-MGLL |
| Title : Discovery of Trifluoromethyl Glycol Carbamates as Potent and Selective Covalent Monoacylglycerol Lipase (MAGL) Inhibitors for Treatment of Neuroinflammation - McAllister_2018_J.Med.Chem_61_3008 |
| Author(s) : McAllister LA , Butler CR , Mente S , O'Neil SV , Fonseca KR , Piro JR , Cianfrogna JA , Foley TL , Gilbert AM , Harris AR , Helal CJ , Johnson DS , Montgomery JI , Nason DM , Noell S , Pandit J , Rogers BN , Samad TA , Shaffer CL , da Silva RG , Uccello DP , Webb D , Brodney MA |
| Ref : Journal of Medicinal Chemistry , 61 :3008 , 2018 |
| Abstract : |
| PubMedSearch : McAllister_2018_J.Med.Chem_61_3008 |
| PubMedID: 29498843 |
| Gene_locus related to this paper: human-MGLL |
| Title : Discovery of Trifluoromethyl Glycol Carbamates as Potent and Selective Covalent Monoacylglycerol Lipase (MAGL) Inhibitors for Treatment of Neuroinflammation - McAllister_2018_J.Med.Chem_61_3008 |
| Author(s) : McAllister LA , Butler CR , Mente S , O'Neil SV , Fonseca KR , Piro JR , Cianfrogna JA , Foley TL , Gilbert AM , Harris AR , Helal CJ , Johnson DS , Montgomery JI , Nason DM , Noell S , Pandit J , Rogers BN , Samad TA , Shaffer CL , da Silva RG , Uccello DP , Webb D , Brodney MA |
| Ref : Journal of Medicinal Chemistry , 61 :3008 , 2018 |
| Abstract : |
| PubMedSearch : McAllister_2018_J.Med.Chem_61_3008 |
| PubMedID: 29498843 |
| Gene_locus related to this paper: human-MGLL |
Representative scheme of Prolylcarboxypeptidase structure and an image from PDBsum server
Databases
PDB-Sum : 6BQ0 Previously Class, Architecture, Topology and Homologous superfamily - PDB-Sum server
FSSP : 6BQ0 Fold classification based on Structure-Structure alignment of Proteins - FSSP server
SCOP : 6BQ0 Structural Classification Of Protein - SCOP server
PROTEOPEDIA : 6BQ0 3D, interactive encyclopedia of proteins - PROTEOPEDIA server