6H14

Name : Crystal structure of Torpedo californica ACHE complexed to 1-(6-oxo-1,2,3,4,6,10b-hexahydropyrido[2,1-a]isoindol-10-yl)-3-(4-(1-(2-((1,2,3,4-tetrahydroacridin-9-yl)amino)ethyl)-1H-1,2,3-triazol-4-yl)pyridin-2-yl)urea

Revelation date : 15-May-2019

Family : ACHE

Gene_locus : torca-ACHE

PDB file : ESTHER: header of PDB entry RCSB: Full entry

Comment
Coquelle, N., Colletier, J.P.

Ligand :

References (1)

Title : Design, biological evaluation and X-ray crystallography of nanomolar multifunctional ligands targeting simultaneously acetylcholinesterase and glycogen synthase kinase-3 - Oukoloff_2019_Eur.J.Med.Chem_168_58
Author(s) : Oukoloff K , Coquelle N , Bartolini M , Naldi M , Le Guevel R , Bach S , Josselin B , Ruchaud S , Catto M , Pisani L , Denora N , Iacobazzi RM , Silman I , Sussman JL , Buron F , Colletier JP , Jean L , Routier S , Renard PY
Ref : Eur Journal of Medicinal Chemistry , 168 :58 , 2019
PubMedID: 30798053
Gene_locus related to this paper: torca-ACHE

Representative scheme of Prolylcarboxypeptidase structure and an image from PDBsum server

Databases

PDB-Sum : 6H14 Previously Class, Architecture, Topology and Homologous superfamily - PDB-Sum server

FSSP : 6H14 Fold classification based on Structure-Structure alignment of Proteins - FSSP server

SCOP : 6H14 Structural Classification Of Protein - SCOP server

PROTEOPEDIA : 6H14 3D, interactive encyclopedia of proteins - PROTEOPEDIA server