7PJR

Name : Structure of the human Wnt deacylase Notum in complex with ARUK3000438

Revelation date : 07-Sep-2022

Family : Pectinacetylesterase-Notum

Gene_locus : human-NOTUM

PDB file : ESTHER: header of PDB entry RCSB: Full entry

Comment
Vecchia, L., Zhao, Y.,Fish, P.,Jones, E.Y.

Ligand :

References (1)

Title : Design of a potent, selective and brain penetrant inhibitor of Wnt-deactivating enzyme Notum by optimization of a crystallographic fragment hit - Willis_2022_J.Med.Chem_65_7212
Author(s) : Willis NJ , Mahy W , Sipthorp J , Zhao Y , Woodward HL , Atkinson BN , Bayle ED , Svensson F , Frew S , Jeganathan F , Monaghan A , Benvegnu S , Jolly S , Vecchia L , Ruza RR , Kjaer S , Howell SA , Snidjers AP , Bictash M , Salinas PC , Vincent JP , Jones EY , Whiting P , Fish PV
Ref : Journal of Medicinal Chemistry , 65 :7212 , 2022
PubMedID: 35536179
Gene_locus related to this paper: human-NOTUM

Representative scheme of Prolylcarboxypeptidase structure and an image from PDBsum server

Databases

PDB-Sum : 7PJR Previously Class, Architecture, Topology and Homologous superfamily - PDB-Sum server

FSSP : 7PJR Fold classification based on Structure-Structure alignment of Proteins - FSSP server

SCOP : 7PJR Structural Classification Of Protein - SCOP server

PROTEOPEDIA : 7PJR 3D, interactive encyclopedia of proteins - PROTEOPEDIA server