8AQF
Name : Crystal structure of human monoacylglycerol lipase in complex with compound LEI-515
Revelation date : 23-Aug-2023
Family : Monoglyceridelipase_lysophospholip
Gene_locus : human-MGLL
PDB file : ESTHER: header of PDB entry RCSB: Full entry
Comment
Jiang, M.,Huizenga, M.,Wirt, J.,Paloczi, J.,Amedi, A.,van der Berg, R.,Benz, J.,Collin, L.,Deng, H.,Driever, W.,Florea, B.,Grether, U.,Janssen, A.,Heitman, L.,Lam, T.W.,Mohr, F.,Pavlovic, A.,Ruf, I.,Rutjes, H.,Stevens, F.,van der Vliet, D.,van der Wel, T.,Wittwer, M.,Boeckel, C.,Pacher, P.,Hohmann, A.,van der Stelt, M.
References (2)
| Title : Structure-Activity Relationship Studies of Aryl Sulfoxides as Reversible Monoacylglycerol Lipase Inhibitors - Jiang_2024_J.Med.Chem__ |
| Author(s) : Jiang M , Huizenga MCW , Mohr F , Amedi A , Bakker R , van den Berg R , Deng H , van der Wel T , van Boeckel CAA , van der Stelt M |
| Ref : Journal of Medicinal Chemistry , : , 2024 |
| Abstract : |
| PubMedSearch : Jiang_2024_J.Med.Chem__ |
| PubMedID: 38988250 |
| Title : A monoacylglycerol lipase inhibitor showing therapeutic efficacy in mice without central side effects or dependence - Jiang_2023_Nat.Commun_14_8039 |
| Author(s) : Jiang M , Huizenga MCW , Wirt JL , Paloczi J , Amedi A , van den Berg R , Benz J , Collin L , Deng H , Di X , Driever WF , Florea BI , Grether U , Janssen APA , Hankemeier T , Heitman LH , Lam TW , Mohr F , Pavlovic A , Ruf I , van den Hurk H , Stevens AF , van der Vliet D , van der Wel T , Wittwer MB , van Boeckel CAA , Pacher P , Hohmann AG , van der Stelt M |
| Ref : Nat Commun , 14 :8039 , 2023 |
| Abstract : |
| PubMedSearch : Jiang_2023_Nat.Commun_14_8039 |
| PubMedID: 38052772 |
Representative scheme of Prolylcarboxypeptidase structure and an image from PDBsum server
Databases
PDB-Sum : 8AQF Previously Class, Architecture, Topology and Homologous superfamily - PDB-Sum server
FSSP : 8AQF Fold classification based on Structure-Structure alignment of Proteins - FSSP server
SCOP : 8AQF Structural Classification Of Protein - SCOP server
PROTEOPEDIA : 8AQF 3D, interactive encyclopedia of proteins - PROTEOPEDIA server