| Title : Radiosynthesis and evaluation of novel (18)F labeled PET ligands for imaging monoacylglycerol lipase - Li_2025_Eur.J.Med.Chem_285_117246 |
| Author(s) : Li Y , Mori W , Chaudhary A , Zhao C , Yamasaki T , Zhang Z , Feng S , Ware T , Rong J , Fujinaga M , Chen J , Kumata K , Zhang Y , Hu K , Xie L , Zhou X , Song Z , Gao Y , Sun Z , Patel JS , Zhai C , Yuan KY , Collier TL , Ran C , Collin L , Haider A , Grether U , Wittwer MB , Cravatt BF , Zhang MR , Liang SH |
| Ref : Eur Journal of Medicinal Chemistry , 285 :117246 , 2025 |
| Abstract : |
| PubMedSearch : Li_2025_Eur.J.Med.Chem_285_117246 |
| PubMedID: 39793441 |
| Gene_locus related to this paper: human-MGLL |
| Title : A Highly Selective and Versatile Probe Platform for Visualization of Monoacylglycerol Lipase - Hentsch_2025_Angew.Chem.Int.Ed.Engl__e202413405 |
| Author(s) : Hentsch A , Guberman M , Radetzki S , Kaushik S , Huizenga M , Paul J , Schippers M , Benz J , Kuhn B , Heer D , Topp A , Esteves Gloria L , Walter A , Hochstrasser R , Wittwer MB , von Kries JP , Collin L , Blaising J , van der Stelt M , Lipstein N , Grether U , Nazare M |
| Ref : Angew Chem Int Ed Engl , :e202413405 , 2025 |
| Abstract : |
| PubMedSearch : Hentsch_2025_Angew.Chem.Int.Ed.Engl__e202413405 |
| PubMedID: 39916545 |
| Title : Exploration of (R)-[(11)C]YH168 as a PET tracer for imaging monoacylglycerol lipase in the brain: from mice to non-human primates - He_2024_Eur.J.Nucl.Med.Mol.Imaging__ |
| Author(s) : He Y , Zheng M , Gu J , Reichert L , Trimborn J , Zhang H , Keller C , Crosby M , Collin L , Heer D , Pavlovic A , Topp A , Wittwer MB , Grether U , Gobbi L , Schibli R , Huang Y , Mu L |
| Ref : Eur J Nucl Med Mol Imaging , : , 2024 |
| Abstract : |
| PubMedSearch : He_2024_Eur.J.Nucl.Med.Mol.Imaging__ |
| PubMedID: 39673602 |
| Title : Structure-Guided Discovery of cis-Hexahydro-pyrido-oxazinones as Reversible, Drug-like Monoacylglycerol Lipase Inhibitors - Kuhn_2024_J.Med.Chem__ |
| Author(s) : Kuhn B , Ritter M , Hornsperger B , Bell C , Kocer B , Rombach D , Lutz MDR , Gobbi L , Kuratli M , Bartelmus C , Burkler M , Koller R , Tosatti P , Ruf I , Guerard M , Pavlovic A , Stephanus J , O'Hara F , Wetzl D , Saal W , Stihle M , Roth D , Hug M , Huber S , Heer D , Kroll C , Topp A , Schneider M , Gertsch J , Glasmacher S , van der Stelt M , Martella A , Wittwer MB , Collin L , Benz J , Richter H , Grether U |
| Ref : Journal of Medicinal Chemistry , : , 2024 |
| Abstract : |
| PubMedSearch : Kuhn_2024_J.Med.Chem__ |
| PubMedID: 39360636 |
| Gene_locus related to this paper: human-MGLL |
| Title : Development of a Highly Selective NanoBRET Probe to Assess MAGL Inhibition in Live Cells - Gazzi_2024_Chembiochem__e202400704 |
| Author(s) : Gazzi T , Brennecke B , Olikauskas V , Hochstrasser R , Wang H , Keen Chao S , Atz K , Mostinski Y , Topp A , Heer D , Kaufmann I , Ritter M , Gobbi L , Hornsperger B , Wagner B , Richter H , O'Hara F , Wittwer MB , Jul Hansen D , Collin L , Kuhn B , Benz J , Grether U , Nazare M |
| Ref : Chembiochem , :e202400704 , 2024 |
| Abstract : |
| PubMedSearch : Gazzi_2024_Chembiochem__e202400704 |
| PubMedID: 39607084 |
| Gene_locus related to this paper: human-MGLL |
| Title : Preclinical Evaluation of the Reversible Monoacylglycerol Lipase PET Tracer (R)-[(11) C]YH132: Application in Drug Development and Neurodegenerative Diseases - He_2024_Chembiochem__e202300819 |
| Author(s) : He Y , Delparente A , Jie C , Keller C , Humm R , Heer D , Collin L , Schibli R , Gobbi L , Grether U , Mu L |
| Ref : Chembiochem , :e202300819 , 2024 |
| Abstract : |
| PubMedSearch : He_2024_Chembiochem__e202300819 |
| PubMedID: 38441502 |
| Title : Pharmacological blockade of 2-AG degradation ameliorates clinical, neuroinflammatory and synaptic alterations in experimental autoimmune encephalomyelitis - Guadalupi_2024_Neuropharmacol__109940 |
| Author(s) : Guadalupi L , Mandolesi G , Vanni V , Balletta S , Caioli S , Pavlovic A , De Vito F , Fresegna D , Sanna K , Vitiello L , Nencini M , Tartacca A , Mariani F , Rovella V , Schippling S , Ruf I , Collin L , Centonze D , Musella A |
| Ref : Neuropharmacology , :109940 , 2024 |
| Abstract : |
| PubMedSearch : Guadalupi_2024_Neuropharmacol__109940 |
| PubMedID: 38570068 |
| Gene_locus related to this paper: human-ABHD6 |
| Title : Enhancing Drug Discovery and Development through the Integration of Medicinal Chemistry, Chemical Biology, and Academia-Industry Partnerships: Insights from Roche's Endocannabinoid System Projects - Aebi_2024_Chimia.(Aarau)_78_499 |
| Author(s) : Aebi J , Atz K , Ametamey SM , Benz J , Blaising J , Butini S , Campiani G , Carreira EM , Collin L , De Lago E , Gazzi T , Gertsch J , Gobbi L , Guba W , Fernandez-Ruiz J , Fingerle J , Haider A , He Y , Heitman LH , Honer M , Hunziker D , Kuhn B , Maccarrone M , Marki HP , Martin RE , Mohr P , Mu L , Nazare M , Nippa DF , Oddi S , O'Hara F , Pacher P , Romero J , Rover S , Rufer AC , Schibli R , Schneider G , Stepan AF , Sykes DA , Ullmer C , van der Stelt M , Veprintsev DB , Wittwer MB , Grether U |
| Ref : Chimia (Aarau) , 78 :499 , 2024 |
| Abstract : |
| PubMedSearch : Aebi_2024_Chimia.(Aarau)_78_499 |
| PubMedID: 39221845 |
| Title : Identification of (R)-[(18)F]YH134 for Monoacylglycerol Lipase Neuroimaging and Exploration of Its Use for Central Nervous System and Peripheral Drug Development - He_2023_J.Nucl.Med__ |
| Author(s) : He Y , Kramer SD , Grether U , Wittwer MB , Collin L , Kuhn B , Topp A , Heer D , O'Hara F , Honer M , Pavlovic A , Richter H , Ritter M , Rombach D , Keller C , Gobbi L , Mu L |
| Ref : J Nucl Med , : , 2023 |
| Abstract : |
| PubMedSearch : He_2023_J.Nucl.Med__ |
| PubMedID: 38164615 |
| Title : A monoacylglycerol lipase inhibitor showing therapeutic efficacy in mice without central side effects or dependence - Jiang_2023_Nat.Commun_14_8039 |
| Author(s) : Jiang M , Huizenga MCW , Wirt JL , Paloczi J , Amedi A , van den Berg R , Benz J , Collin L , Deng H , Di X , Driever WF , Florea BI , Grether U , Janssen APA , Hankemeier T , Heitman LH , Lam TW , Mohr F , Pavlovic A , Ruf I , van den Hurk H , Stevens AF , van der Vliet D , van der Wel T , Wittwer MB , van Boeckel CAA , Pacher P , Hohmann AG , van der Stelt M |
| Ref : Nat Commun , 14 :8039 , 2023 |
| Abstract : |
| PubMedSearch : Jiang_2023_Nat.Commun_14_8039 |
| PubMedID: 38052772 |
| Title : Discovery, synthesis and evaluation of novel reversible monoacylglycerol lipase radioligands bearing a morpholine-3-one scaffold - He_2022_Nucl.Med.Biol_108-109_24 |
| Author(s) : He Y , Gobbi LC , Herde AM , Rombach D , Ritter M , Kuhn B , Wittwer MB , Heer D , Hornsperger B , Bell C , O'Hara F , Benz J , Honer M , Keller C , Collin L , Richter H , Schibli R , Grether U , Mu L |
| Ref : Nucl Med Biol , 108-109 :24 , 2022 |
| Abstract : |
| PubMedSearch : He_2022_Nucl.Med.Biol_108-109_24 |
| PubMedID: 35248850 |
| Gene_locus related to this paper: human-MGLL |
| Title : Development of High Brain-Penetrant and Reversible Monoacylglycerol Lipase PET Tracers for Neuroimaging - He_2022_J.Med.Chem_65_2191 |
| Author(s) : He Y , Schild M , Grether U , Benz J , Leibrock L , Heer D , Topp A , Collin L , Kuhn B , Wittwer M , Keller C , Gobbi LC , Schibli R , Mu L |
| Ref : Journal of Medicinal Chemistry , 65 :2191 , 2022 |
| Abstract : |
| PubMedSearch : He_2022_J.Med.Chem_65_2191 |
| PubMedID: 35089028 |
| Gene_locus related to this paper: human-MGLL |
| Title : A potent and selective inhibitor for the modulation of MAGL activity in the neurovasculature - Kemble_2022_PLoS.One_17_e0268590 |
| Author(s) : Kemble AM , Hornsperger B , Ruf I , Richter H , Benz J , Kuhn B , Heer D , Wittwer M , Engelhardt B , Grether U , Collin L |
| Ref : PLoS ONE , 17 :e0268590 , 2022 |
| Abstract : |
| PubMedSearch : Kemble_2022_PLoS.One_17_e0268590 |
| PubMedID: 36084029 |
| Gene_locus related to this paper: human-MGLL |
| Title : Multi-parameter optimization: Development of a morpholin-3-one derivative with an improved kinetic profile for imaging monoacylglycerol lipase in the brain - He_2022_Eur.J.Med.Chem_243_114750 |
| Author(s) : He Y , Grether U , Taddio MF , Meier C , Keller C , Edelmann MR , Honer M , Huber S , Wittwer MB , Heer D , Richter H , Collin L , Hug MN , Hilbert M , Postmus AGJ , Stevens AF , van der Stelt M , Kramer SD , Schibli R , Mu L , Gobbi LC |
| Ref : Eur Journal of Medicinal Chemistry , 243 :114750 , 2022 |
| Abstract : |
| PubMedSearch : He_2022_Eur.J.Med.Chem_243_114750 |
| PubMedID: 36137365 |
| Gene_locus related to this paper: human-MGLL , mouse-MGLL |