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Structure Report for: 2CMF

Name|Torpedo californica acetylcholinesterase complexed with alkylene- linked bis-tacrine dimer (5 carbon linker)
Revelation date|04-Sep-2006
Family|ACHE: there are 546 genes in this family, 315 structure(s)
PDB File|ESTHER: header of PDB entry RCSB: Full entry
Rydberg, E.H., Greenblatt, H.M., Wong, D.M., Pang, Y.P., Silman, I., Sussman, J.L
Ligand|Inhibitor: Bis5-tacrine Ligand in structure: Ligplot


    Title: Complexes of alkylene-linked tacrine dimers with Torpedo californica acetylcholinesterase: Binding of Bis5-tacrine produces a dramatic rearrangement in the active-site gorge
    Rydberg EH, Brumshtein B, Greenblatt HM, Wong DM, Shaya D, Williams LD, Carlier PR, Pang YP, Silman I, Sussman JL
    Ref: Journal of Medicinal Chemistry, 49:5491, 2006 : PubMed


Representative scheme of ACHE structure and an image from PDBsum server


PDB-Sum2CMF Previously Class, Architecture, Topology and Homologous superfamily - PDB-Sum server
FSSP2CMF Fold classification based on Structure-Structure alignment of Proteins - FSSP server
SCOP2CMF Structural Classification Of Protein - SCOP server
PROTEOPEDIA2cmf 3D, interactive encyclopedia of proteins - PROTEOPEDIA server

Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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