Sulfur mustard (military designation: HD) is a thick liquid at ambient temperature, but solid at 14.4 C. It is heavier than water as a liquid and heavier than air as a vapor. It is often called mustard gas, but sulfur mustard is not likely to change into a gas immediately if it is released at ordinary temperatures. As a pure liquid, it is colorless and odorless, but when mixed with other chemicals, it looks brown and has a garlic-like smell. Bis(2-chloroethyl) sulfide; dichlorodiethyl sulfide is very toxic, and can be absorbed through the skin. Exposure to this substance is corrosive to the eyes, skin and lungs and leads to blindness and blistering of the skin and can cause severe and sometimes fatal respiratory damage. Sulfur mustard has been used in chemical warfare and was made in large amounts during World Wars I and II. It was reportedly used in the Iran-Iraq war in 1980-1988: vesicant and a carcinogenic agent. Sulfur mustard (SM) can be hydrolyzed by haloalkane dehalogenases such as DhaA, LinB and DmbA, also hydrolyzed by Chloroperoxidase (not alpha/beta hydrolase)
Type : Chemical Warfare Agent, Sulfur Compound
Chemical_Nomenclature : 1-chloro-2-(2-chloroethylsulfanyl)ethane
Canonical SMILES : C(CCl)SCCCl
InChI : InChI=1S\/C4H8Cl2S\/c5-1-3-7-4-2-6\/h1-4H2
InChIKey : QKSKPIVNLNLAAV-UHFFFAOYSA-N
Other name(s) : Mustard gas || Sulfur mustard || Yperite || Senfgas || Iprit || HD || SCHEMBL43809 || bis-(2-chloro-ethyl)-sulfane || CHEMBL455341
Structures : No structure
Families : Haloalkane_dehalogenase-HLD2, Haloalkane_dehalogenase-HLD1
Title : Cation-Exchangeable Pralidoxime Chloride@bio-MOF-1 as a Treatment for Nerve Agent Poisoning and Sulfur Mustard Skin Poisoning in Animals - Yang_2022_ACS.Omega_7_30720 |
Author(s) : Yang Y , Liu J , Liu L , Zhou Y , Zhang L , Zhong Y , Zhao D , Wang Y |
Ref : ACS Omega , 7 :30720 , 2022 |
Abstract : |
PubMedSearch : Yang_2022_ACS.Omega_7_30720 |
PubMedID: 36092617 |
Title : Skin decontamination efficacy of sulfur mustard and VX in the pig model: A comparison between Fuller's earth and RSDL - Dachir_2021_Chem.Biol.Interact_336_109393 |
Author(s) : Dachir S , Cohen M , Buch H , Kadar T |
Ref : Chemico-Biological Interactions , 336 :109393 , 2021 |
Abstract : |
PubMedSearch : Dachir_2021_Chem.Biol.Interact_336_109393 |
PubMedID: 33508307 |
Title : Bacillus subtilis Spore Surface Display of Haloalkane Dehalogenase DhaA - Wang_2019_Curr.Microbiol_76_1161 |
Author(s) : Wang F , Song T , Jiang H , Pei C , Huang Q , Xi H |
Ref : Curr Microbiol , 76 :1161 , 2019 |
Abstract : |
PubMedSearch : Wang_2019_Curr.Microbiol_76_1161 |
PubMedID: 31278426 |
Gene_locus related to this paper: xanau-halo1 |
Title : Development of fluorescent assay for monitoring of dehalogenase activity - Nevolova_2018_Biotechnol.J__e1800144 |
Author(s) : Nevolova S , Manaskova E , Mazurenko S , Damborsky J , Prokop Z |
Ref : Biotechnol J , :e1800144 , 2018 |
Abstract : |
PubMedSearch : Nevolova_2018_Biotechnol.J__e1800144 |
PubMedID: 30052322 |
Title : Characterization of FM2382 from Fulvimarina manganoxydans sp. Nov. 8047 with potential enzymatic decontamination of sulfur mustard - Zhao_2018_Protein.Expr.Purif_141_63 |
Author(s) : Zhao YZ , Guo X , Zhong JY , Guo N , Chen LC , Dong ZY |
Ref : Protein Expr Purif , 141 :63 , 2018 |
Abstract : |
PubMedSearch : Zhao_2018_Protein.Expr.Purif_141_63 |
PubMedID: 28807839 |
Title : Cognitive and emotional impairments after cutaneous intoxication by CEES (a sulfur mustard analog) in mice - Gros-Desormeaux_2018_Toxicol.Lett_293_73 |
Author(s) : Gros-Desormeaux F , Beracochea D , Dorandeu F , Pierard C |
Ref : Toxicol Lett , 293 :73 , 2018 |
Abstract : |
PubMedSearch : Gros-Desormeaux_2018_Toxicol.Lett_293_73 |
PubMedID: 28743565 |
Title : Sulfur mustard induced oxidative stress and its alteration using asoxime (HI-6) - Pohanka_2013_Interdiscip.Toxicol_6_198 |
Author(s) : Pohanka M , Sobotka J , Svobodova H , Stetina R |
Ref : Interdiscip Toxicol , 6 :198 , 2013 |
Abstract : |
PubMedSearch : Pohanka_2013_Interdiscip.Toxicol_6_198 |
PubMedID: 24678258 |
Title : Apoptosis in sulfur mustard treated A549 cell cultures - Steinritz_2007_Life.Sci_80_2199 |
Author(s) : Steinritz D , Emmler J , Hintz M , Worek F , Kreppel H , Szinicz L , Kehe K |
Ref : Life Sciences , 80 :2199 , 2007 |
Abstract : |
PubMedSearch : Steinritz_2007_Life.Sci_80_2199 |
PubMedID: 17229443 |