Mustard-gas

Sulfur mustard (military designation: HD) is a thick liquid at ambient temperature, but solid at 14.4 C. It is heavier than water as a liquid and heavier than air as a vapor. It is often called mustard gas, but sulfur mustard is not likely to change into a gas immediately if it is released at ordinary temperatures. As a pure liquid, it is colorless and odorless, but when mixed with other chemicals, it looks brown and has a garlic-like smell. Bis(2-chloroethyl) sulfide; dichlorodiethyl sulfide is very toxic, and can be absorbed through the skin. Exposure to this substance is corrosive to the eyes, skin and lungs and leads to blindness and blistering of the skin and can cause severe and sometimes fatal respiratory damage. Sulfur mustard has been used in chemical warfare and was made in large amounts during World Wars I and II. It was reportedly used in the Iran-Iraq war in 1980-1988: vesicant and a carcinogenic agent. Sulfur mustard (SM) can be hydrolyzed by haloalkane dehalogenases such as DhaA, LinB and DmbA, also hydrolyzed by Chloroperoxidase (not alpha/beta hydrolase)

General

Type : Chemical Warfare Agent, Sulfur Compound

Chemical_Nomenclature : 1-chloro-2-(2-chloroethylsulfanyl)ethane

Canonical SMILES : C(CCl)SCCCl

InChI : InChI=1S\/C4H8Cl2S\/c5-1-3-7-4-2-6\/h1-4H2

InChIKey : QKSKPIVNLNLAAV-UHFFFAOYSA-N

Other name(s) : Mustard gas  ||  Sulfur mustard  ||  Yperite  ||  Senfgas  ||  Iprit  ||  HD  ||  SCHEMBL43809  ||  bis-(2-chloro-ethyl)-sulfane  ||  CHEMBL455341


MW :

Formula : C4H8Cl2S

CAS_number :

PubChem : 10461

UniChem : QKSKPIVNLNLAAV-UHFFFAOYSA-N

Target

Structures : No structure

Families : Haloalkane_dehalogenase-HLD2, Haloalkane_dehalogenase-HLD1

References (8)

Title : Cation-Exchangeable Pralidoxime Chloride@bio-MOF-1 as a Treatment for Nerve Agent Poisoning and Sulfur Mustard Skin Poisoning in Animals - Yang_2022_ACS.Omega_7_30720
Author(s) : Yang Y , Liu J , Liu L , Zhou Y , Zhang L , Zhong Y , Zhao D , Wang Y
Ref : ACS Omega , 7 :30720 , 2022
Abstract :
PubMedSearch : Yang_2022_ACS.Omega_7_30720
PubMedID: 36092617

Title : Skin decontamination efficacy of sulfur mustard and VX in the pig model: A comparison between Fuller's earth and RSDL - Dachir_2021_Chem.Biol.Interact_336_109393
Author(s) : Dachir S , Cohen M , Buch H , Kadar T
Ref : Chemico-Biological Interactions , 336 :109393 , 2021
Abstract :
PubMedSearch : Dachir_2021_Chem.Biol.Interact_336_109393
PubMedID: 33508307

Title : Bacillus subtilis Spore Surface Display of Haloalkane Dehalogenase DhaA - Wang_2019_Curr.Microbiol_76_1161
Author(s) : Wang F , Song T , Jiang H , Pei C , Huang Q , Xi H
Ref : Curr Microbiol , 76 :1161 , 2019
Abstract :
PubMedSearch : Wang_2019_Curr.Microbiol_76_1161
PubMedID: 31278426
Gene_locus related to this paper: xanau-halo1

Title : Development of fluorescent assay for monitoring of dehalogenase activity - Nevolova_2018_Biotechnol.J__e1800144
Author(s) : Nevolova S , Manaskova E , Mazurenko S , Damborsky J , Prokop Z
Ref : Biotechnol J , :e1800144 , 2018
Abstract :
PubMedSearch : Nevolova_2018_Biotechnol.J__e1800144
PubMedID: 30052322

Title : Characterization of FM2382 from Fulvimarina manganoxydans sp. Nov. 8047 with potential enzymatic decontamination of sulfur mustard - Zhao_2018_Protein.Expr.Purif_141_63
Author(s) : Zhao YZ , Guo X , Zhong JY , Guo N , Chen LC , Dong ZY
Ref : Protein Expr Purif , 141 :63 , 2018
Abstract :
PubMedSearch : Zhao_2018_Protein.Expr.Purif_141_63
PubMedID: 28807839

Title : Cognitive and emotional impairments after cutaneous intoxication by CEES (a sulfur mustard analog) in mice - Gros-Desormeaux_2018_Toxicol.Lett_293_73
Author(s) : Gros-Desormeaux F , Beracochea D , Dorandeu F , Pierard C
Ref : Toxicol Lett , 293 :73 , 2018
Abstract :
PubMedSearch : Gros-Desormeaux_2018_Toxicol.Lett_293_73
PubMedID: 28743565

Title : Sulfur mustard induced oxidative stress and its alteration using asoxime (HI-6) - Pohanka_2013_Interdiscip.Toxicol_6_198
Author(s) : Pohanka M , Sobotka J , Svobodova H , Stetina R
Ref : Interdiscip Toxicol , 6 :198 , 2013
Abstract :
PubMedSearch : Pohanka_2013_Interdiscip.Toxicol_6_198
PubMedID: 24678258

Title : Apoptosis in sulfur mustard treated A549 cell cultures - Steinritz_2007_Life.Sci_80_2199
Author(s) : Steinritz D , Emmler J , Hintz M , Worek F , Kreppel H , Szinicz L , Kehe K
Ref : Life Sciences , 80 :2199 , 2007
Abstract :
PubMedSearch : Steinritz_2007_Life.Sci_80_2199
PubMedID: 17229443