Oxybutinin
An antispasmodic used for the treatment of overactive bladder. It has a role as a muscarinic antagonist, a muscle relaxant, an antispasmodic drug, a parasympatholytic, a calcium channel blocker and a local anaesthetic.
General
Type : Drug, Not AlphaBeta Hydrolase target, Pro-Drug, Muscarinic antagonist, Neuromuscular Nondepolarizing Agents, Alkyne
Chemical_Nomenclature : 4-(diethylamino)but-2-ynyl 2-cyclohexyl-2-hydroxy-2-phenylacetate
Canonical SMILES : CCN(CC)CC#CCOC(=O)C(C1CCCCC1)(C2=CC=CC=C2)O
InChI : InChI=1S\/C22H31NO3\/c1-3-23(4-2)17-11-12-18-26-21(24)22(25,19-13-7-5-8-14-19)20-15-9-6-10-16-20\/h5,7-8,13-14,20,25H,3-4,6,9-10,15-18H2,1-2H3
InChIKey : XIQVNETUBQGFHX-UHFFFAOYSA-N
Other name(s) : Ditropan || Oxytrol || Oxibutyninum || kentera || Oxybutynine || Oxybutinin || CHEBI:7856 || CHEMBL1231
MW : 357.5
Formula : C22H31NO3
CAS_number : 5633-20-5
PubChem : 4634
UniChem : XIQVNETUBQGFHX-UHFFFAOYSA-N
Target
Structures : No structure
Families : Carb_B_Chordata
References (8)
| Title : Difference in substrate specificity of carboxylesterase and arylacetamide deacetylase between dogs and humans - Yoshida_2018_Eur.J.Pharm.Sci_111_167 |
| Author(s) : Yoshida T , Fukami T , Kurokawa T , Gotoh S , Oda A , Nakajima M |
| Ref : Eur J Pharm Sci , 111 :167 , 2018 |
| Abstract : |
| PubMedSearch : Yoshida_2018_Eur.J.Pharm.Sci_111_167 |
| PubMedID: 28966098 |
| Gene_locus related to this paper: canfa-CESDD1 , canfa-f1p6w8 , canlf-e2r2h2 |
| Title : Simultaneous absolute protein quantification of carboxylesterases 1 and 2 in human liver tissue fractions using liquid chromatography-tandem mass spectrometry - Sato_2012_Drug.Metab.Dispos_40_1389 |
| Author(s) : Sato Y , Miyashita A , Iwatsubo T , Usui T |
| Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , 40 :1389 , 2012 |
| Abstract : |
| PubMedSearch : Sato_2012_Drug.Metab.Dispos_40_1389 |
| PubMedID: 22504157 |
| Title : Conclusive identification of the oxybutynin-hydrolyzing enzyme in human liver - Sato_2012_Drug.Metab.Dispos_40_902 |
| Author(s) : Sato Y , Miyashita A , Iwatsubo T , Usui T |
| Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , 40 :902 , 2012 |
| Abstract : |
| PubMedSearch : Sato_2012_Drug.Metab.Dispos_40_902 |
| PubMedID: 22293119 |
| Title : Changes in utilisation of anticholinergic drugs after initiation of cholinesterase inhibitors - Robinson_2009_Pharmacoepidemiol.Drug.Saf_18_659 |
| Author(s) : Robinson M , Rowett D , Leverton A , Mabbott V |
| Ref : Pharmacoepidemiol Drug Safety , 18 :659 , 2009 |
| Abstract : |
| PubMedSearch : Robinson_2009_Pharmacoepidemiol.Drug.Saf_18_659 |
| PubMedID: 19548222 |
| Title : Dual use of bladder anticholinergics and cholinesterase inhibitors: long-term functional and cognitive outcomes - Sink_2008_J.Am.Geriatr.Soc_56_847 |
| Author(s) : Sink KM , Thomas J, 3rd , Xu H , Craig B , Kritchevsky S , Sands LP |
| Ref : J Am Geriatr Soc , 56 :847 , 2008 |
| Abstract : |
| PubMedSearch : Sink_2008_J.Am.Geriatr.Soc_56_847 |
| PubMedID: 18384584 |
| Title : Allosteric kinetics of human carboxylesterase 1: species differences and interindividual variability - Takahashi_2008_J.Pharm.Sci_97_5434 |
| Author(s) : Takahashi S , Katoh M , Saitoh T , Nakajima M , Yokoi T |
| Ref : J Pharm Sci , 97 :5434 , 2008 |
| Abstract : |
| PubMedSearch : Takahashi_2008_J.Pharm.Sci_97_5434 |
| PubMedID: 18383336 |
| Title : Effect of antimuscarinic drugs used for overactive bladder on learning in a rat passive avoidance response test - Suzuki_2007_Eur.J.Pharmacol_557_154 |
| Author(s) : Suzuki M , Noguchi Y , Okutsu H , Ohtake A , Sasamata M |
| Ref : European Journal of Pharmacology , 557 :154 , 2007 |
| Abstract : |
| PubMedSearch : Suzuki_2007_Eur.J.Pharmacol_557_154 |
| PubMedID: 17207478 |
| Title : Hydrolytic profile for ester- or amide-linkage by carboxylesterases pI 5.3 and 4.5 from human liver - Takai_1997_Biol.Pharm.Bull_20_869 |
| Author(s) : Takai S , Matsuda A , Usami Y , Adachi T , Sugiyama T , Katagiri Y , Tatematsu M , Hirano K |
| Ref : Biol Pharm Bull , 20 :869 , 1997 |
| Abstract : |
| PubMedSearch : Takai_1997_Biol.Pharm.Bull_20_869 |
| PubMedID: 9300133 |
| Gene_locus related to this paper: human-CES1 , human-CES2 |