Patulin
Patulin is a mycotoxin produced by a variety of molds, particularly Aspergillus and Penicillium. It is commonly found in rotting apples. It is not a particularly potent toxin, but a number of studies have shown that it is genotoxic. Patulin is also an antibiotic. Several countries have instituted patulin restrictions in apple products. The World Health Organization recommends a maximum concentration of 50 ug/L in apple juice. Patulin has been shown to exhibit apoptotic and antibiotic functions. Patulin belongs to the family of Pyrans.
General
Type : Natural, Toxin, Antibiotic
Chemical_Nomenclature : 4-hydroxy-4,6-dihydrofuro[3,2-c]pyran-2-one
Canonical SMILES : C1C=C2C(=CC(=O)O2)C(O1)O
InChI : InChI=1S\/C7H6O4\/c8-6-3-4-5(11-6)1-2-10-7(4)9\/h1,3,7,9H,2H2
InChIKey : ZRWPUFFVAOMMNM-UHFFFAOYSA-N
Other name(s) : Clavacin || Clavatin || Expansin || Patuline || Expansine || Claviform || Claviformin || Leucopin || Terinin || Gigantin || Mycoin || Penicidin || Tercinin || Mycoine || Mycosin || Penatin || CHEBI:74926 || DB15586 || SCHEMBL29056
MW : 154.12
Formula : C7H6O4
CAS_number : 149-29-1
PubChem : 4696
UniChem : ZRWPUFFVAOMMNM-UHFFFAOYSA-N
Target
Structures : No structure
Families : Pancreatic_lipase, Dienelactone_hydrolase
References (9)
| Title : Identification, Characterization, and Application of a Novel Highly Efficient Thermostable Patulin-Degrading Enzyme from Acetomicrobium hydrogeniformans - Wang_2025_J.Agric.Food.Chem_73_15307 |
| Author(s) : Wang H , Liang X , Chen X , Xu N , Chen Y , Zhang W , Yan M , Wei R , Qin H , Wu Q , Gao J , Liu W |
| Ref : Journal of Agricultural and Food Chemistry , 73 :15307 , 2025 |
| Abstract : |
| PubMedSearch : Wang_2025_J.Agric.Food.Chem_73_15307 |
| PubMedID: 40471067 |
| Gene_locus related to this paper: 9bact-a0a1h3g281 |
| Title : Identification, Characterization, and Application of a Novel Highly Efficient Thermostable Patulin-Degrading Enzyme from Acetomicrobium hydrogeniformans - Wang_2025_J.Agric.Food.Chem_73_15307 |
| Author(s) : Wang H , Liang X , Chen X , Xu N , Chen Y , Zhang W , Yan M , Wei R , Qin H , Wu Q , Gao J , Liu W |
| Ref : Journal of Agricultural and Food Chemistry , 73 :15307 , 2025 |
| Abstract : |
| PubMedSearch : Wang_2025_J.Agric.Food.Chem_73_15307 |
| PubMedID: 40471067 |
| Gene_locus related to this paper: 9bact-a0a1h3g281 |
| Title : Identification, Characterization, and Application of a Novel Highly Efficient Thermostable Patulin-Degrading Enzyme from Acetomicrobium hydrogeniformans - Wang_2025_J.Agric.Food.Chem_73_15307 |
| Author(s) : Wang H , Liang X , Chen X , Xu N , Chen Y , Zhang W , Yan M , Wei R , Qin H , Wu Q , Gao J , Liu W |
| Ref : Journal of Agricultural and Food Chemistry , 73 :15307 , 2025 |
| Abstract : |
| PubMedSearch : Wang_2025_J.Agric.Food.Chem_73_15307 |
| PubMedID: 40471067 |
| Gene_locus related to this paper: 9bact-a0a1h3g281 |
| Title : Effective degradation of the mycotoxin patulin in pear juice by porcine pancreatic lipase - Xiao_2019_Food.Chem.Toxicol_133_110769 |
| Author(s) : Xiao Y , Liu B , Wang Z , Han C , Meng X , Zhang F |
| Ref : Food & Chemical Toxicology , 133 :110769 , 2019 |
| Abstract : |
| PubMedSearch : Xiao_2019_Food.Chem.Toxicol_133_110769 |
| PubMedID: 31442469 |
| Gene_locus related to this paper: pig-1plip |
| Title : Effective degradation of the mycotoxin patulin in pear juice by porcine pancreatic lipase - Xiao_2019_Food.Chem.Toxicol_133_110769 |
| Author(s) : Xiao Y , Liu B , Wang Z , Han C , Meng X , Zhang F |
| Ref : Food & Chemical Toxicology , 133 :110769 , 2019 |
| Abstract : |
| PubMedSearch : Xiao_2019_Food.Chem.Toxicol_133_110769 |
| PubMedID: 31442469 |
| Gene_locus related to this paper: pig-1plip |
| Title : Effective degradation of the mycotoxin patulin in pear juice by porcine pancreatic lipase - Xiao_2019_Food.Chem.Toxicol_133_110769 |
| Author(s) : Xiao Y , Liu B , Wang Z , Han C , Meng X , Zhang F |
| Ref : Food & Chemical Toxicology , 133 :110769 , 2019 |
| Abstract : |
| PubMedSearch : Xiao_2019_Food.Chem.Toxicol_133_110769 |
| PubMedID: 31442469 |
| Gene_locus related to this paper: pig-1plip |
| Title : Sequencing, physical organization and kinetic expression of the patulin biosynthetic gene cluster from Penicillium expansum - Tannous_2014_Int.J.Food.Microbiol_189_51 |
| Author(s) : Tannous J , El Khoury R , Snini SP , Lippi Y , El Khoury A , Atoui A , Lteif R , Oswald IP , Puel O |
| Ref : Int J Food Microbiol , 189 :51 , 2014 |
| Abstract : |
| PubMedSearch : Tannous_2014_Int.J.Food.Microbiol_189_51 |
| PubMedID: 25120234 |
| Gene_locus related to this paper: penen-a0a075txz3 |
| Title : Sequencing, physical organization and kinetic expression of the patulin biosynthetic gene cluster from Penicillium expansum - Tannous_2014_Int.J.Food.Microbiol_189_51 |
| Author(s) : Tannous J , El Khoury R , Snini SP , Lippi Y , El Khoury A , Atoui A , Lteif R , Oswald IP , Puel O |
| Ref : Int J Food Microbiol , 189 :51 , 2014 |
| Abstract : |
| PubMedSearch : Tannous_2014_Int.J.Food.Microbiol_189_51 |
| PubMedID: 25120234 |
| Gene_locus related to this paper: penen-a0a075txz3 |
| Title : Sequencing, physical organization and kinetic expression of the patulin biosynthetic gene cluster from Penicillium expansum - Tannous_2014_Int.J.Food.Microbiol_189_51 |
| Author(s) : Tannous J , El Khoury R , Snini SP , Lippi Y , El Khoury A , Atoui A , Lteif R , Oswald IP , Puel O |
| Ref : Int J Food Microbiol , 189 :51 , 2014 |
| Abstract : |
| PubMedSearch : Tannous_2014_Int.J.Food.Microbiol_189_51 |
| PubMedID: 25120234 |
| Gene_locus related to this paper: penen-a0a075txz3 |