Tween-20
Model substrate for lipases or phospholipase. but also used as excipient, surface-active agent (detergent, emulsifier). Used as model substrate for TLE1 and TLE2 secreted by the bacterial type VI secretion system (T6SS)
General
Type : Polysorbate, Detergent, Dodecanoate, Laurate
Chemical_Nomenclature : 2-[2-[3,4-bis(2-hydroxyethoxy)oxolan-2-yl]-2-(2-hydroxyethoxy)ethoxy]ethyl dodecanoate
Canonical SMILES : CCCCCCCCCCCC(=O)OCCOCC(C1C(C(CO1)OCCO)OCCO)OCCO
InChI : InChI=1S\/C26H50O10\/c1-2-3-4-5-6-7-8-9-10-11-24(30)34-19-18-31-20-22(32-15-12-27)26-25(35-17-14-29)23(21-36-26)33-16-13-28\/h22-23,25-29H,2-21H2,1H3
InChIKey : HMFKFHLTUCJZJO-UHFFFAOYSA-N
Other name(s) : Tween20 || Tween 20 || Polysorbate 20 || Polysorbate (INN) || Polysorbate || Polyoxyethylene sorbitan monolaurate
MW : 522.66
Formula : C26H50O10
CAS_number : 9005-64-5
PubChem : 443314
UniChem : HMFKFHLTUCJZJO-UHFFFAOYSA-N
Target
Structures : No structure
Families : T6SS-TLE1, Lipase_3, Canar_LipB, LYsophospholipase_carboxylesterase
References (6)
| Title : Identification of Acyl-Protein Thioesterase-1 as a Polysorbate-degrading Host Cell Protein in a Monoclonal Antibody Formulation Using Activity-based Protein Profiling - Sprager_2024_J.Pharm.Sci__ |
| Author(s) : Sprager E , Moller J , Lin Y , Reisinger V , Bratkovic T , Lunder M , Vasl J , Krajnc A |
| Ref : J Pharm Sci , : , 2024 |
| Abstract : |
| PubMedSearch : Sprager_2024_J.Pharm.Sci__ |
| PubMedID: 38772451 |
| Gene_locus related to this paper: human-LYPLA1 |
| Title : Stress-mediated polysorbate 20 degradation and its potential impact on therapeutic proteins - Aryal_2024_Pharm.Res__ |
| Author(s) : Aryal B , Lehtimaki M , Rao VA |
| Ref : Pharm Res , : , 2024 |
| Abstract : |
| PubMedSearch : Aryal_2024_Pharm.Res__ |
| PubMedID: 38740663 |
| Title : Hydrolysis of Polysorbate 20 and 80 by a Range of Carboxylester Hydrolases - McShan_2016_PDA.J.Pharm.Sci.Technol_70_332 |
| Author(s) : McShan AC , Kei P , Ji JA , Kim DC , Wang YJ |
| Ref : PDA J Pharm Sci Technol , 70 :332 , 2016 |
| Abstract : |
| PubMedSearch : McShan_2016_PDA.J.Pharm.Sci.Technol_70_332 |
| PubMedID: 27020650 |
| Title : Uml2 is a novel CalB-type lipase of Ustilago maydis with phospholipase A activity - Buerth_2014_Appl.Microbiol.Biotechnol_98_4963 |
| Author(s) : Buerth C , Kovacic F , Stock J , Terfruchte M , Wilhelm S , Jaeger KE , Feldbrugge M , Schipper K , Ernst JF , Tielker D |
| Ref : Applied Microbiology & Biotechnology , 98 :4963 , 2014 |
| Abstract : |
| PubMedSearch : Buerth_2014_Appl.Microbiol.Biotechnol_98_4963 |
| PubMedID: 24469105 |
| Gene_locus related to this paper: ustma-q4pep1 |
| Title : Diverse type VI secretion phospholipases are functionally plastic antibacterial effectors - Russell_2013_Nature_496_508 |
| Author(s) : Russell AB , LeRoux M , Hathazi K , Agnello DM , Ishikawa T , Wiggins PA , Wai SN , Mougous JD |
| Ref : Nature , 496 :508 , 2013 |
| Abstract : |
| PubMedSearch : Russell_2013_Nature_496_508 |
| PubMedID: 23552891 |
| Gene_locus related to this paper: ecoli-T6SS.TLE3 |
| Title : Production of lipase by clinical isolates of Pseudomonas cepacia - Lonon_1988_J.Clin.Microbiol_26_979 |
| Author(s) : Lonon MK , Woods DE , Straus DC |
| Ref : J Clin Microbiol , 26 :979 , 1988 |
| Abstract : |
| PubMedSearch : Lonon_1988_J.Clin.Microbiol_26_979 |
| PubMedID: 3384918 |