Tween-80

General

Type : Polysorbate, Detergent, Oleate

Chemical_Nomenclature : 2-[2-[3,4-bis(2-hydroxyethoxy)oxolan-2-yl]-2-(2-hydroxyethoxy)ethoxy]ethyl (E)-octadec-9-enoate

Canonical SMILES : CCCCCCCCC=CCCCCCCCC(=O)OCCOCC(C1C(C(CO1)OCCO)OCCO)OCCO

InChI : InChI=1S\/C32H60O10\/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-30(36)40-25-24-37-26-28(38-21-18-33)32-31(41-23-20-35)29(27-42-32)39-22-19-34\/h9-10,28-29,31-35H,2-8,11-27H2,1H3\/b10-9+

InChIKey : HDTIFOGXOGLRCB-MDZDMXLPSA-N

Other name(s) : Tween 80  ||  Glycol (polysorbate 80)  ||  Polysorbate-81  ||  Polyoxyethylene sorbitan oleate  ||  Polyethylene oxide sorbitan mono-oleate  ||  Polyoxyethylene (20) sorbitan monooleate  ||  AC1NQZCF


MW : 604.82

Formula : C32H60O10

CAS_number :

PubChem : 5281955,    5284448

UniChem : HDTIFOGXOGLRCB-MDZDMXLPSA-N

References (5)

Title : Identification of Acyl-Protein Thioesterase-1 as a Polysorbate-degrading Host Cell Protein in a Monoclonal Antibody Formulation Using Activity-based Protein Profiling - Sprager_2024_J.Pharm.Sci__
Author(s) : Sprager E , Moller J , Lin Y , Reisinger V , Bratkovic T , Lunder M , Vasl J , Krajnc A
Ref : J Pharm Sci , : , 2024
Abstract :
PubMedSearch : Sprager_2024_J.Pharm.Sci__
PubMedID: 38772451
Gene_locus related to this paper: human-LYPLA1

Title : Profiling Active Enzymes for Polysorbate Degradation in Biotherapeutics by Activity-Based Protein Profiling - Li_2021_Anal.Chem_93_8161
Author(s) : Li X , Chandra D , Letarte S , Adam GC , Welch J , Yang RS , Rivera S , Bodea S , Dow A , Chi A , Strulson CA , Richardson DD
Ref : Analytical Chemistry , 93 :8161 , 2021
Abstract :
PubMedSearch : Li_2021_Anal.Chem_93_8161
PubMedID: 34032423
Gene_locus related to this paper: human-PLA2G7

Title : Rapid Polysorbate 80 Degradation by Liver Carboxylesterase in a Monoclonal Antibody Formulated Drug Substance at Early Stage Development - Zhang_2020_J.Pharm.Sci_109_3300
Author(s) : Zhang S , Xiao H , Molden R , Qiu H , Li N
Ref : J Pharm Sci , 109 :3300 , 2020
Abstract :
PubMedSearch : Zhang_2020_J.Pharm.Sci_109_3300
PubMedID: 32721471
Gene_locus related to this paper: crigr-g3i7x7 , crigr-a0a061i7x9

Title : Hydrolysis of Polysorbate 20 and 80 by a Range of Carboxylester Hydrolases - McShan_2016_PDA.J.Pharm.Sci.Technol_70_332
Author(s) : McShan AC , Kei P , Ji JA , Kim DC , Wang YJ
Ref : PDA J Pharm Sci Technol , 70 :332 , 2016
Abstract :
PubMedSearch : McShan_2016_PDA.J.Pharm.Sci.Technol_70_332
PubMedID: 27020650

Title : Uml2 is a novel CalB-type lipase of Ustilago maydis with phospholipase A activity - Buerth_2014_Appl.Microbiol.Biotechnol_98_4963
Author(s) : Buerth C , Kovacic F , Stock J , Terfruchte M , Wilhelm S , Jaeger KE , Feldbrugge M , Schipper K , Ernst JF , Tielker D
Ref : Applied Microbiology & Biotechnology , 98 :4963 , 2014
Abstract :
PubMedSearch : Buerth_2014_Appl.Microbiol.Biotechnol_98_4963
PubMedID: 24469105
Gene_locus related to this paper: ustma-q4pep1