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Substrate Report for: Lysophosphatidylserine


General
Type: Phospholipid, Lysophosphospholipid
Chemical_Nomenclature: (2~{S})-2-amino-3-[hydroxy-[(2~{R})-2-hydroxy-3-octadecanoyloxypropoxy]phosphoryl]oxypropanoic acid
Canonical SMILES: CCCCCCCCCCCCCCCCCC(=O)OCC(COP(=O)(O)OCC(C(=O)O)N)O
InChI: InChI=1S/C24H48NO9P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-23(27)32-18-21(26)19-33-35(30,31)34-20-22(25)24(28)29/h21-22,26H,2-20,25H2,1H3,(H,28,29)(H,30,31)/t21-,22+/m1/s1
InChIKey: ZPDQFUYPBVXUKS-YADHBBJMSA-N
Other name(s): 1-Octadecanoyl-sn-glycero-3-phosphoserine ; LysoPS ; Lyso-PS ; Lysophosphatidyl-L-serine ; CHEBI:85403 ; PS(18:0/0:0) ; LPS(18:0) ; CHEMBL582985 ; SCHEMBL17482440 ; ZINC49722989
MW: 525.62
Formula: C24H48NO9P
CAS_number:
PubChem: 42607474
IUPHAR:
Wikipedia:

Target families
Lysophosphatidylserine ligand of proteins in family: ABHD12-PHARC, Phospholipase
No structure

Protein target

References
Search PubMed for references concerning: Lysophosphatidylserine

3 more
    Title: Discovery and Optimization of Selective and in Vivo Active Inhibitors of the Lysophosphatidylserine Lipase alpha/beta-Hydrolase Domain-Containing 12 (ABHD12)
    Ogasawara D, Ichu TA, Jing H, Hulce JJ, Reed A, Ulanovskaya OA, Cravatt BF
    Ref: Journal of Medicinal Chemistry, 62:1643, 2019 : PubMed

            

    Title: Immunomodulatory lysophosphatidylserines are regulated by ABHD16A and ABHD12 interplay
    Kamat SS, Camara K, Parsons WH, Chen DH, Dix MM, Bird TD, Howell AR, Cravatt BF
    Ref: Nat Chemical Biology, 11:164, 2015 : PubMed

            

    Title: ABHD12 controls brain lysophosphatidylserine pathways that are deregulated in a murine model of the neurodegenerative disease PHARC
    Blankman JL, Long JZ, Trauger SA, Siuzdak G, Cravatt BF
    Ref: Proc Natl Acad Sci U S A, 110:1500, 2013 : PubMed