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ABHD12-PHARC

Relationship

Family: ABHD12-PHARC

Block: X

Parent Family: Hydrolase_4

Comment

Monoacylglycerol lipase protein ABHD12 (also known as the abhydrolase domain-containing protein 12) has 2-arachidonoylglycerol hydrolase activity (Blankman et al. 2007). In humans, defects in ABHD12 are the cause of polyneuropathy hearing loss ataxia retinitis pigmentosa and cataract (PHARC). PHARC is a slowly progressive neurologic disorder (Fiskerstrand 2010). ABHD12 is a major very long chain lyso-PS lipase in primary mast cells. long-chain lyso-PSs induce secretion of pro-inflammatory cytokines in macrophage signaling and mast cell degranulation (Khandelwal 2021). Substrates include: 2-arachidonoylglycerol, 1(3)-isomer of arachidonoylglycerol, unsaturated C20:4 monoacylglycerols, lysophosphatidylserine lipids

Database

Interpro : IPR026605 Monoacylglycerol lipase protein ABHD12

PIRSF : No PIRSF

Pdoc : No Pdoc

Pfam : No Pfam

Prints : No Print

EC Number : No EC Number

Sequences

Peptide in Fasta
Nucleotide in Fasta
Alignment with Multalin Text only
Seed alignment with MAFFT No colour / coloured with Mview
Alignment with MAFFT No colour / coloured with Mview
Dendrogram The dnd file

Gene_locus Name Species
9acar-a0a023gbq9 Amblyomma triste. Putative abhydrolase domain protein Amblyomma triste
9acar-a0a131xkd9 Hyalomma excavatum. Putative monoacylglycerol lipase abhd12-like isoform 2 Hyalomma excavatum
9acar-l7mcp1 Rhipicephalus pulchellus. Putative abhydrolase domain protein Rhipicephalus pulchellus
9arac-a0a087uwy6 Stegodyphus mimosarum. Monoacylglycerol lipase ABHD12 Stegodyphus mimosarum
9basi-a0a3g2s527 Malassezia restricta CBS 7877. Monoacylglycerol lipase ABHD12 Malassezia restricta CBS 7877
9bila-a0a016wyk0 Ancylostoma ceylanicum. Uncharacterized protein Ancylostoma ceylanicum
9bila-a0a085mjs6 Trichuris suis (pig whipworm). Uncharacterized protein Trichuris suis
9bila-a0a0c2cxc4 Ancylostoma duodenale. Uncharacterized protein Ancylostoma duodenale
9bila-a0a0k0fvl8 Strongyloides venezuelensis. Uncharacterized protein Strongyloides venezuelensis
9bila-a0a0r3rxj2 Elaeophora elaphi. Uncharacterized protein Elaeophora elaphi
9bila-a0a0v1ab74 Trichinella patagoniensis (Trichina worm) (patagoniensis\; nativa\; nelsoni\; murrelli\; spiralis\; sp.). Monoacylglycerol lipase ABHD12 Trichinella patagoniensis
9bila-a0a183i0l9 Onchocerca flexuosa. Uncharacterized protein Onchocerca flexuosa
9bila-a0a1i7ys27 Steinernema glaseri. Uncharacterized protein Steinernema glaseri
9bila-a0a1i8d2w3 Rhabditophanes sp. KR3021. Uncharacterized protein Rhabditophanes sp. KR3021
9crus-a0a0n8djk4 Daphnia magna. Abhydrolase domain-containing protein Daphnia magna
9crus-a0a0n8dnp0 Daphnia magna. Monoacylglycerol lipase ABHD12 Daphnia magna
9dipt-a0a182ivt1 Anopheles atroparvus. Uncharacterized protein Anopheles atroparvus
9dipt-a0a182jvm5 Anopheles christyi. Uncharacterized protein Anopheles christyi
9dipt-a0a182ksz6 Anopheles coluzzii. Uncharacterized protein Anopheles coluzzii
9dipt-a0a182mfn5 Anopheles culicifacies. Uncharacterized protein Anopheles culicifacies
9dipt-a0a182pge0 Anopheles epiroticus. Uncharacterized protein Anopheles epiroticus
9dipt-a0a182qfv3 Anopheles farauti. Uncharacterized protein Anopheles farauti
9dipt-a0a182w296 Anopheles minimus. Uncharacterized protein Anopheles minimus
9dipt-a0a1l8dxz2 Nyssomyia neivai. Putative monoacylglycerol lipase abhd12 Nyssomyia neivai
9dipt-u5etp8 Corethrella appendiculata. Putative monoacylglycerol lipase abhd12 Corethrella appendiculata
9euca-a0a0p4vxn2 Scylla olivacea (orange mud crab). Uncharacterized protein Scylla olivacea
9euca-a0a0p4wre6 Scylla olivacea (orange mud crab). Uncharacterized protein Scylla olivacea
9eupu-a0a0b7b861 Arion vulgaris. Uncharacterized protein Arion vulgaris
9eupu-a0a0b7ba72 Arion vulgaris. Uncharacterized protein Arion vulgaris
9hemi-a0a1b6d3h0 Clastoptera arizonana (Arizona spittle bug). Uncharacterized protein Clastoptera arizonana
9hemi-a0a1b6kqe8 Graphocephala atropunctata. Uncharacterized protein Graphocephala atropunctata
9hyme-a0a0l7rc58 Habropoda laboriosa. Monoacylglycerol lipase ABHD12 Habropoda laboriosa
9hyme-a0a151k026 Trachymyrmex septentrionalis\; Trachymyrmex cornetzi\; Trachymyrmex zeteki. Monoacylglycerol lipase ABHD12 Trachymyrmex septentrionalis
9hyme-a0a195cjl1 Cyphomyrmex costatus. Monoacylglycerol lipase ABHD12 Cyphomyrmex costatus
9metz-a0a177b9r9 Intoshia linei. Abhydrolase domain-containing protein 12 Intoshia linei
9pelo-a0a1i7szm6 Caenorhabditis tropicalis. Uncharacterized protein Caenorhabditis tropicalis
9plat-a0a1i8h217 Macrostomum lignano. Uncharacterized protein Macrostomum lignano
9saur-a0a098lz36 Hypsiglena sp. JMG-2014. Monoacylglycerol lipase ABHD12 Hypsiglena sp. JMG-2014
9scar-a0a0t6b0r7 Oryctes borbonicus. Hydrolase Oryctes borbonicus
9tele-a0a1a7wsk8 Aphyosemion striatum (Beira killifish)\; Nothobranchius (kuhntae\; pienaari\; korthausae). Abhydrolase domain containing 12 Aphyosemion striatum
9tele-a0a1a8qlc7 Nothobranchius rachovii (bluefin notho, Turquoise killifish, Beira killifish\; furzeri\; korthausae\;.kadleci\; kuhntae\; pienaari) Abhydrolase domain containing 12 Nothobranchius rachovii
acypi-j9l398 Acyrthosiphon pisum (Pea aphid). Uncharacterized protein Acyrthosiphon pisum
aedae-q170k7 Aedes aegypti (Yellowfever mosquito) putative uncharacterized protein Aedes aegypti
aedal-a0a023erc5 Aedes albopictus (Asian tiger mosquito) (Stegomyia albopicta). Putative abhydrolase domain protein Aedes albopictus
ailme-g1lu36 Ailuropoda melanoleuca (Giant panda) Uncharacterized protein Ailuropoda melanoleuca
allmi-a0a151m1n2 Alligator mississippiensis (American alligator). Monoacylglycerol lipase ABHD12 Alligator mississippiensis
ampqe-i1g3h8 Amphimedon queenslandica (Sponge). Uncharacterized protein Amphimedon queenslandica
angcs-a0a0r3pqd1 Angiostrongylus costaricensis (Nematode worm)\; Angiostrongylus cantonensis (Rat lungworm). Uncharacterized protein Angiostrongylus costaricensis
anisi-a0a0m3k415 Anisakis simplex (Herring worm). Uncharacterized protein Anisakis simplex
anoal-a0a182fvn2 Anopheles albimanus (New world malaria mosquito). Uncharacterized protein Anopheles albimanus
anoca-g1kpn9 Anolis carolinensis (Green anole) (American chameleon). Uncharacterized protein Anolis carolinensis
anoda-w5jty7 Anopheles darlingi (Mosquito). Uncharacterized protein Anopheles darlingi
anofn-a0a182rw65 Anopheles funestus (African malaria mosquito). Uncharacterized protein Anopheles funestus
anoga-a0ngj1 Anopheles gambiae str. PEST (A. quadriannulatus\; A. melas\; A. merus\; A. arabiensis agap012189-pa Anopheles gambiae
anogl-v5g7r7 Anoplophora glabripennis (Asian longhorn beetle) (Anoplophora nobilis). Monoacylglycerol lipase Anoplophora glabripennis
anogl-v5gw93 Anoplophora glabripennis (Asian longhorn beetle) (Anoplophora nobilis). Monoacylglycerol lipase ABHD12 Anoplophora glabripennis
anosi-a0a084wum0 Anopheles sinensis (Mosquito). Uncharacterized protein Anopheles sinensis
anost-a0a1a9thh9 Anopheles stephensi (Indo-Pakistan malaria mosquito). Uncharacterized protein Anopheles stephensi
apime-a0a088aj98 Apis mellifera (Honeybee)\; Apis cerana. Uncharacterized protein Apis mellifera
asclu-a0a0m3imf4 Ascaris lumbricoides (Giant roundworm). Uncharacterized protein Ascaris lumbricoides
ascsu-f1l6n2 Ascaris suum (Pig roundworm) (Ascaris lumbricoides). Monoacylglycerol lipase abhd12 Ascaris suum
astmx-w5kwi0 Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus). Uncharacterized protein Astyanax mexicanus
attce-a0a158nij4 Atta cephalotes (Leafcutter ant). Uncharacterized protein Atta cephalotes
baccu-a0a0a1x0e2 Bactrocera cucurbitae (Melon fruit fly) (Dacus cucurbitae). Monoacylglycerol lipase ABHD12 Bactrocera cucurbitae
bovin-f1mps6 Bos taurus (Bovine) Uncharacterized protein Bos taurus
bovin-q08dw9 Bos taurus (Bovine), Bos mutus (wild Yak) abhydrolase domain containing protein 12 Bos taurus
brafl-c3xr79 Branchiostoma floridae (Florida lancelet) (Amphioxus). Putative uncharacterized protein Branchiostoma floridae
brupa-a0a0n4tvu7 Brugia pahangi (Filarial nematode worm)\; Brugia timori\; Brugia malayi. Uncharacterized protein Brugia pahangi
burxy-a0a1i7rsb1 Bursaphelenchus xylophilus (Pinewood nematode worm) (Aphelenchoides xylophilus). Uncharacterized protein Bursaphelenchus xylophilus
caebe-g0ms22 Caenorhabditis brenneri (Nematode worm). Putative uncharacterized protein Caenorhabditis brenneri
caebr-A8X6Z9 Caenorhabditis briggsae hypothetical protein cbg08612 (fragment) Caenorhabditis briggsae
caeel-Y97E10AL.2 Caenorhabditis elegans hypothetical protein y97e10al.2 Caenorhabditis elegans
caeja-h2wda2 Caenorhabditis japonica. Uncharacterized protein Caenorhabditis japonica
caere-e3lnw3 Caenorhabditis remanei (Caenorhabditis vulgaris). Putative uncharacterized protein Caenorhabditis remanei
calcm-c1c095 Caligus clemensi (Sea louse). Abhydrolase domain-containing protein 12 Caligus clemensi
calja-f6rae1 Callithrix jacchus (White-tufted-ear marmoset). Uncharacterized protein Callithrix jacchus
calja-f7gcw8 Callithrix jacchus (White-tufted-ear marmoset) Uncharacterized protein Callithrix jacchus
calmi-v9ku67 Callorhinchus milii (Ghost shark). Monoacylglycerol lipase ABHD12-like protein Callorhinchus milii
camfo-e2a7b9 Camponotus floridanus (Florida carpenter ant). Abhydrolase domain-containing protein 12 Camponotus floridanus
canfa-f1pb79 Canis lupus familiaris (Dog) (Canis familiaris) Uncharacterized protein Canis lupus familiaris
canlf-e2rjg6 Canis lupus familiaris (Dog) (Canis familiaris). Uncharacterized protein Canis lupus familiaris
capte-r7ud05 Capitella teleta (Polychaete worm). Uncharacterized protein Capitella teleta
cavpo-h0v2c4 Cavia porcellus (Guinea pig). Uncharacterized protein Cavia porcellus
cerbi-a0a026w8e0 Cerapachys biroi (Ant). Monoacylglycerol lipase ABHD12 Cerapachys biroi
cerca-w8bwm7 Ceratitis capitata (Mediterranean fruit fly) (Tephritis capitata). Monoacylglycerol lipase ABHD12 Ceratitis capitata
cerca-w8c4w6 Ceratitis capitata (Mediterranean fruit fly) (Tephritis capitata). Monoacylglycerol lipase ABHD12 Ceratitis capitata
chick-q5zin0 Gallus gallus (Chicken) hypothetical protein Gallus gallus
cragi-k1qq58 Crassostrea gigas (Pacific oyster) (Crassostrea angulata). Monoacylglycerol lipase ABHD12 Crassostrea gigas
croad-j3s4l1 Crotalus adamanteus (Eastern diamondback rattlesnake)\; Crotalus horridus (Timber rattlesnake). Monoacylglycerol lipase ABHD12-like protein Crotalus adamanteus
culqu-b0wf88 Culex quinquefasciatus (Southern house mosquito) (Culex pungens). Putative uncharacterized protein Culex quinquefasciatus
cupsa-t1e1q2 Cupiennius salei (American wandering spider). Putative monoacylglycerol lipase Cupiennius salei
danre-q08c93 Danio rerio (Zebrafish) (Brachydanio rerio) abhydrolase domain containing 12 Danio rerio
dappu-e9glp5 Daphnia pulex (Water flea). Putative uncharacterized protein Daphnia pulex
dappu-e9glp6 Daphnia pulex (Water flea). Putative uncharacterized protein Daphnia pulex
denpd-n6trb6 Dendroctonus ponderosae (Mountain pine beetle). Uncharacterized protein Dendroctonus ponderosae
desro-k9ijl7 Desmodus rotundus (Vampire bat). Putative monoacylglycerol lipase abhd12 Desmodus rotundus
dicvi-a0a0d8yby5 Dictyocaulus viviparus (Bovine lungworm). Uncharacterized protein Dictyocaulus viviparus
drame-a0a0n4ur74 Dracunculus medinensis (Guinea worm). Uncharacterized protein Dracunculus medinensis
drogr-b4jvm7 Drosophila grimshawi (Fruit fly) (Idiomyia grimshawi). GH22637 Drosophila grimshawi
drome-CG15111 Drosophila melanogaster (Fruit fly) cg15111 protein re26090p Drosophila melanogaster
dromo-b4ku70 Drosophila mojavensis (Fruit fly). Uncharacterized protein, isoform A Drosophila mojavensis
drops-q28wj5 Drosophila pseudoobscura (Fruit fly) ga13500-pa (fragment) Drosophila pseudoobscura
drovi-b4mcn9 Drosophila virilis (Fruit fly). Uncharacterized protein, isoform F Drosophila virilis
felca-m3w9k2 Felis catus (Cat) (Felis silvestris catus). Uncharacterized protein Felis catus
fical-u3jdg9 Ficedula albicollis (Collared flycatcher) (Muscicapa albicollis) and many birds. Uncharacterized protein Ficedula albicollis
fukda-a0a091dnk2 Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis). Monoacylglycerol lipase ABHD12 Fukomys damarensis
funhe-a0a146rn38 Fundulus heteroclitus (Killifish) (Mummichog). Monoacylglycerol lipase ABHD12 Fundulus heteroclitus
glomm-a0a1b0fqf9 Glossina morsitans morsitans (Savannah tsetse fly). Uncharacterized protein Glossina morsitans morsitans
gorgo-g3reg6 Gorilla gorilla gorilla (Western lowland gorilla). Uncharacterized protein Gorilla gorilla gorilla
haeco-u6nsf0 Haemonchus contortus (Barber pole worm). Alpha beta hydrolase fold-1 domain containing protein Haemonchus contortus
haepc-a0a0n4wlp9 Haemonchus placei (Barber's pole worm). Uncharacterized protein Haemonchus placei
harsa-e2c8h0 Harpegnathos saltator (Jerdon's jumping ant). Abhydrolase domain-containing protein 12 Harpegnathos saltator
helam-a0a2w1bfr0 Helicoverpa armigera (Cotton bollworm) (Heliothis armigera) ABHD12 Helicoverpa armigera
helbk-a0a183fgj5 Heligmosomoides polygyrus bakeri (Parasitic nematode) (Heligmosomoides bakeri). Uncharacterized protein Heligmosomoides polygyrus bakeri
helro-t1fm33 Helobdella robusta (Californian leech). Uncharacterized protein Helobdella robusta
hetba-a0a1i7xln9 Heterorhabditis bacteriophora (Entomopathogenic nematode). Uncharacterized protein Heterorhabditis bacteriophora
horse-f6x5e5 Equus caballus (Horse) Uncharacterized protein Equus caballus
horse-f7adj7 Equus caballus (Horse). Uncharacterized protein Equus caballus
human-ABHD12 Homo sapiens (Human) abhydrolase domain-containing protein 12. Protein C20orf22, flj90542, CT022, 2-arachidonoylglycerol hydrolase, Monoacylglycerol lipase Homo sapiens
human-ABHD12B Homo sapiens (Human) Abhydrolase domain-containing protein 12B ABHD12B protein c14orf29 Homo sapiens
icttr-i3mmv0 Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus tridecemlineatus). Uncharacterized protein Ictidomys tridecemlineatus
lasni-a0a0j7krm8 Lasius niger (Black garden ant). Abhydrolase domain-containing protein 12 Lasius niger
lepoc-w5njb5 Lepisosteus oculatus (Spotted gar). Uncharacterized protein Lepisosteus oculatus
lepsm-a0a0k2swh0 Lepeophtheirus salmonis (Salmon louse). Abhydrolase domain containing 12 [Danio rerio] Lepeophtheirus salmonis
loalo-a0a1i7vgt8 Loa loa (Eye worm) (Filaria loa). Uncharacterized protein Loa loa
lotgi-v4a5l7 Lottia gigantea (Giant owl limpet). Uncharacterized protein Lottia gigantea
loxaf-g3sq73 Loxodonta africana (African elephant). Uncharacterized protein Loxodonta africana
loxaf-g3tf36 Loxodonta africana (African elephant) Uncharacterized protein Loxodonta africana
lyghe-a0a0a9xhw2 Lygus hesperus (Western plant bug). Monoacylglycerol lipase ABHD12 Lygus hesperus
macfa-g7pa87 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) Putative uncharacterized protein Macaca fascicularis
macfa-q4r766 Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey) reading frame 22 (c20orf22) Macaca fascicularis
macmu-a0a1d5rbr3 Macaca mulatta (Rhesus macaque). Uncharacterized protein Macaca mulatta
macmu-f7flv1 Macaca mulatta (Rhesus macaque) Uncharacterized protein Macaca mulatta
melha-a0a1i8byx0 Meloidogyne hapla (Root-knot nematode worm). Uncharacterized protein Meloidogyne hapla
mizye-a0a210qyk8 Mizuhopecten yessoensis (Japanese scallop) (Patinopecten yessoensis). Oxidized phosphatidylserine lipase ABHD12 Mizuhopecten yessoensis
mondo-f7eyv1 Monodelphis domestica (Gray short-tailed opossum). Uncharacterized protein Monodelphis domestica
mouse-abd12 Mus musculus (Mouse) abhydrolase domain-containing protein 12 protein c20orf22 CT022 (fragment) Mus musculus
mouse-g3uzn6 Mus musculus (Mouse) Protein Abhd12b Mus musculus
myolu-g1pds0 Myotis lucifugus\; Myotis davidii\; Myotis brandtii (Little brown bat, David's myotis, Brandt's bat). Uncharacterized protein Myotis lucifugus
myolu-g1pqr8 Myotis lucifugus (Little brown bat) Uncharacterized protein Myotis lucifugus
nasvi-k7iwe2 Nasonia vitripennis (Parasitic wasp). Uncharacterized protein Nasonia vitripennis
nipbr-a0a0n4yqe2 Nippostrongylus brasiliensis (Rat hookworm). Uncharacterized protein Nippostrongylus brasiliensis
nomle-g1rnx1 Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys) Uncharacterized protein Nomascus leucogenys
octbm-a0a0l8g4j2 Octopus bimaculoides (California two-spotted octopus). Uncharacterized protein Octopus bimaculoides
oesde-a0a0b1t3j9 Oesophagostomum dentatum (Nodular worm). Uncharacterized protein Oesophagostomum dentatum
oncmy-a0a060w9c6 Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri). Uncharacterized protein Oncorhynchus mykiss
oncvo-a0a044u1k7 Onchocerca volvulus (Filarial nematode worm)\; Onchocerca ochengi. Uncharacterized protein Onchocerca volvulus
oncvo-a0a044u301 Onchocerca volvulus (Filarial nematode worm)\; Onchocerca ochengi. Uncharacterized protein Onchocerca volvulus
ophha-v8p760 Ophiophagus hannah (King cobra) (Naja hannah)\; Micrurus fulvius (Eastern coral snake). Monoacylglycerol lipase ABHD12 Ophiophagus hannah
ornan-f6vpb6 Ornithorhynchus anatinus (Duckbill platypus) Uncharacterized protein Ornithorhynchus anatinus
oryla-h2lc35 Oryzias latipes (Japanese rice fish) (Japanese killifish). Uncharacterized protein Oryzias latipes
otoga-h0wym2 Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby). Uncharacterized protein Otolemur garnettii
otoga-h0xay7 Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby) Uncharacterized protein Otolemur garnettii
pantr-h2q8a3 Pan troglodytes (Chimpanzee) Uncharacterized protein Pan troglodytes
pantr-k7awg2 Pan troglodytes (Chimpanzee). Abhydrolase domain containing 12 Pan troglodytes
papan-a0a096nvv7 Papio anubis (Olive baboon). Uncharacterized protein Papio anubis
papxu-a0a194q858 Papilio xuthus (Asian swallowtail butterfly). Monoacylglycerol lipase ABHD12 Similar to CG15111 Papilio xuthus
parti-a0a0n4z950 Parastrongyloides trichosuri (Possum-specific nematode worm). Uncharacterized protein Parastrongyloides trichosuri
parti-a0a0n5a1y4 Parastrongyloides trichosuri (Possum-specific nematode worm). Uncharacterized protein Parastrongyloides trichosuri
pelsi-k7f735 Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis). Uncharacterized protein Pelodiscus sinensis
petma-s4rky2 Petromyzon marinus (Sea lamprey). Uncharacterized protein Petromyzon marinus
phlpp-a0a1b0gq17 Phlebotomus papatasi (Sandfly). Uncharacterized protein Phlebotomus papatasi
pig-i3lfg5 Sus scrofa (Pig) Uncharacterized protein Sus scrofa
pig-i3lga2 Sus scrofa (Pig). Uncharacterized protein Sus scrofa
pripa-h3esz7 Pristionchus pacificus (Parasitic nematode). Uncharacterized protein Pristionchus pacificus
pteal-l5jzi4 Pteropus alecto (Black flying fox). Monoacylglycerol lipase ABHD12 Pteropus alecto
rabit-g1sic4 Oryctolagus cuniculus (Rabbit). Uncharacterized protein Oryctolagus cuniculus
rabit-g1t9l8 Oryctolagus cuniculus (Rabbit) Uncharacterized protein Oryctolagus cuniculus
ramva-a0a1d1unv1 Ramazzottius varieornatus (Water bear) (Tardigrade). Uncharacterized protein Ramazzottius varieornatus
ratno-q6ayt7 Rattus norvegicus (Rat) ABD12 Lysophosphatidylserine lipase ABHD12 Rattus norvegicus
rhopr-t1h967 Rhodnius prolixus (Triatomid bug). Uncharacterized protein Rhodnius prolixus
sarha-g3vfr7 Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius) Uncharacterized protein Sarcophilus harrisii
sarha-g3wyt9 Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius). Uncharacterized protein Sarcophilus harrisii
sheep-w5pcd7 Ovis aries (Sheep). Uncharacterized protein Ovis aries
solin-e9i8e5 Solenopsis invicta (Red imported fire ant) (Solenopsis wagneri). Putative uncharacterized protein Solenopsis invicta
spetr-i3mia1 Spermophilus tridecemlineatus (Thirteen-lined ground squirrel) (Ictidomys tridecemlineatus) Uncharacterized protein Spermophilus tridecemlineatus
strea-a0a0n5c0k4 Strongyloides papillosus (Intestinal threadworm). Uncharacterized protein Strongyloides papillosus
strmm-t1iie7 Strigamia maritima (European centipede) (Geophilus maritimus). Uncharacterized protein Strigamia maritima
strrb-a0a090lcy4 Strongyloides ratti (Parasitic roundworm). Uncharacterized protein Strongyloides ratti
tabbr-a0a0k8tlp2 Tabanus bromius (Band-eyed brown horse fly). Putative monoacylglycerol lipase abhd12 Tabanus bromius
taegu-h0z3k5 Taeniopygia guttata (Zebra finch) (Poephila guttata). Uncharacterized protein Taeniopygia guttata
takru-h2st11 Takifugu rubripes (Japanese pufferfish) (Fugu rubripes). Uncharacterized protein Takifugu rubripes
tetng-q4ref8 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) chromosome 10 scaf15123, whole genome shotgun sequence Tetraodon nigroviridis
tetur-t1klq7 Tetranychus urticae (Two-spotted spider mite). Uncharacterized protein Tetranychus urticae
thecl-a0a0n5cwh6 Thelazia callipaeda (Oriental eyeworm) (Parasitic nematode). Uncharacterized protein Thelazia callipaeda
tingu-a0a099zef1 Tinamus guttatus (White-throated tinamou). Monoacylglycerol lipase ABHD12 Tinamus guttatus
toxca-a0a0b2vem2 Toxocara canis (Canine roundworm). Monoacylglycerol lipase ABHD12 Toxocara canis
tridm-a0a0v0gc71 Triatoma dimidiata (Kissing bug). Putative monoacylglycerol lipase abhd12-like protein Triatoma dimidiata
triif-a0a023f7g0 Triatoma infestans (Assassin bug). Putative monoacylglycerol lipase abhd12-like protein Triatoma infestans
trimr-a0a0n5e009 Trichuris muris (Mouse whipworm). Uncharacterized protein Trichuris muris
trips-a0a0v1g4z3 Trichinella pseudospiralis (Parasitic roundworm)\; Trichinella zimbabwensis\; Trichinella papuae. Monoacylglycerol lipase ABHD12 Trichinella pseudospiralis
tritr-a0a077zgc2 Trichuris trichiura (Whipworm) (Trichocephalus trichiurus). Monoacylglycerol lipase ABHD12 Trichuris trichiura
wucba-a0a183xw05 Wuchereria bancrofti. Uncharacterized protein Wuchereria bancrofti
xenla-a0a1l8g1u7 Xenopus laevis (African clawed frog). Uncharacterized protein Xenopus laevis
xenla-a0a1l8g7v4 Xenopus laevis (African clawed frog). Uncharacterized protein Xenopus laevis
xentr-abd12 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) Abhydrolase domain-containing protein 12 Xenopus tropicalis
xipma-m4ans2 Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus)\; Poeciliopsis prolifica. Uncharacterized protein Xiphophorus maculatus
zoone-a0a067qhm6 Zootermopsis nevadensis (Dampwood termite). Monoacylglycerol lipase ABHD12 Zootermopsis nevadensis

Gene_locus_frgt Name Species
9bila-a0a0r3rax6 Brugia timori. Uncharacterized protein Brugia timori
9bila-a0a0r3rsq8 Elaeophora elaphi. Uncharacterized protein Elaeophora elaphi
9bila-a0a183h1y9 Onchocerca flexuosa. Uncharacterized protein Onchocerca flexuosa
9dipt-a0a182mb20 Anopheles culicifacies. Uncharacterized protein Anopheles culicifacies
9hemi-a0a1b6gbg6 Cuerna arida. Uncharacterized protein Cuerna arida
9hemi-a0a1b6ggt0 Cuerna arida. Uncharacterized protein Cuerna arida
9hemi-a0a1b6itx3 Homalodisca liturata. Uncharacterized protein Homalodisca liturata
9hyme-a0a154nx57 Dufourea novaeangliae. Monoacylglycerol lipase ABHD12 Dufourea novaeangliae
9neop-q5mgg1 Lonomia obliqua hypothetical protein (fragment) Lonomia obliqua
9tele-a0a0p7u1k4 Scleropages formosus (Asian bonytongue). Uncharacterized protein Scleropages formosus
9tele-a0a0p7v141 Scleropages formosus (Asian bonytongue). Uncharacterized protein Scleropages formosus
9trem-a0a183rh22 Schistosoma rodhaini\; Schistosoma curassoni. Uncharacterized protein Schistosoma rodhaini
aedal-a0a182h362 Aedes albopictus (Asian tiger mosquito) (Stegomyia albopicta). Uncharacterized protein Aedes albopictus
amaae-a0a0q3q193 Amazona aestiva (Blue-fronted Amazon parrot). Monoacylglycerol lipase ABHD12 Amazona aestiva
anoaq-t1dp31 Anopheles aquasalis (Malaria mosquito). Putative monoacylglycerol lipase abhd12 Anopheles aquasalis
anogl-v5g8c2 Anoplophora glabripennis (Asian longhorn beetle) (Anoplophora nobilis). Monoacylglycerol lipase Anoplophora glabripennis
anogl-v5gdw9 Anoplophora glabripennis (Asian longhorn beetle) (Anoplophora nobilis). Monoacylglycerol lipase ABHD12 Anoplophora glabripennis
bruma-a0a0h5sbg8 Brugia malayi (Filarial nematode worm). Bm7207 Brugia malayi
brupa-a0a0n4trv2 Brugia pahangi (Filarial nematode worm). Uncharacterized protein Brugia pahangi
camfr-s9wzi4 Camelus ferus (Wild bactrian camel) (Camelus bactrianus ferus). Uncharacterized protein Camelus ferus
chemy-m7bh88 Chelonia mydas (Green sea-turtle) (Chelonia agassizi). Monoacylglycerol lipase ABHD12 Chelonia mydas
crigr-g3h6z2 Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus). Monoacylglycerol lipase ABHD12 Cricetulus griseus
gasac-g3per3 Gasterosteus aculeatus (Three-spined stickleback). Uncharacterized protein Gasterosteus aculeatus
gorgo-g3rvi6 Gorilla gorilla gorilla (Lowland gorilla) Uncharacterized protein Gorilla gorilla gorilla
larcr-a0a0f8awa1 Larimichthys crocea (Large yellow croaker) (Pseudosciaena crocea). Monoacylglycerol lipase ABHD12 Larimichthys crocea
necam-w2ti88 Necator americanus (Human hookworm). Uncharacterized protein Necator americanus
neole-a0a1a6g1y7 Neotoma lepida (Desert woodrat). Uncharacterized protein Neotoma lepida
nipbr-a0a0n4ylr6 Nippostrongylus brasiliensis (Rat hookworm). Uncharacterized protein Nippostrongylus brasiliensis
nipbr-a0a0n4ywg0 Nippostrongylus brasiliensis (Rat hookworm). Uncharacterized protein Nippostrongylus brasiliensis
orcci-a0a1d2mkz4 Orchesella cincta (Springtail). Monoacylglycerol lipase ABHD12 Orchesella cincta
oreni-i3jj62 Oreochromis niloticus (Nile tilapia) (Tilapia nilotica). Uncharacterized protein Oreochromis niloticus
ornan-f7g483 Ornithorhynchus anatinus (Duckbill platypus). Uncharacterized protein Ornithorhynchus anatinus
papma-a0a0n0pcr0 Papilio machaon (Old World swallowtail butterfly). Monoacylglycerol lipase ABHD12 Papilio machaon
petma-s4rkc8 Petromyzon marinus (Sea lamprey). Uncharacterized protein Petromyzon marinus
poefo-a0a087ym43 Poecilia formosa (Amazon molly) (Limia formosa). Uncharacterized protein Poecilia formosa
strpu-w4yhs9 Strongylocentrotus purpuratus (Purple sea urchin). Uncharacterized protein Strongylocentrotus purpuratus
tetng-h3d765 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis). Uncharacterized protein Tetraodon nigroviridis
tetng-q4s2n4 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis). Chromosome 17 SCAF14760, whole genome shotgun sequence Tetraodon nigroviridis
thecl-a0a0n5d6f0 Thelazia callipaeda (Oriental eyeworm) (Parasitic nematode). Uncharacterized protein Thelazia callipaeda
toxca-a0a183u654 Toxocara canis (Canine roundworm). Uncharacterized protein Toxocara canis
tupch-l8y957 Tupaia chinensis (Chinese tree shrew). Monoacylglycerol lipase ABHD12 Tupaia chinensis
wucba-a0a183y992 Wuchereria bancrofti. Uncharacterized protein Wuchereria bancrofti

Substrate Chemical Nomenclature Proteins
2-Arachidonylglycerol 1,3-dihydroxypropan-2-yl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate human-MGLL    human-ABHD6    human-ABHD12    mouse-Ces2c    human-CES2    human-ABHD2    pseae-PA2949    pig-PLE1    pig-a0a1s6l967    human-CES1
Lyso-PS-(20-4) human-ABHD12
Lysophosphatidylserine (2~{S})-2-amino-3-[hydroxy-[(2~{R})-2-hydroxy-3-octadecanoyloxypropoxy]phosphoryl]oxypropanoic acid human-ABHD12    human-PLA1A    yeast-FSH1
PGE2-glyceryl-ester 2,3-dihydroxypropyl (Z)-7-[(1R,2R,3R)-3-hydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]-5-oxocyclopentyl]hept-5-enoate human-ABHD12    human-ABHD6    human-MGLL    human-CES1

Inhibitor Chemical Nomenclature Proteins
Betulinic-acid (1R,3aS,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-9-hydroxy-5a,5b,8,8,11a-pentamethyl-1-prop-1-en-2-yl-1,2,3,4,5,6,7,7a,9,10,11,11b,12,13,13a,13b-hexadecahydrocyclopenta[a]chrysene-3a-carboxylic acid human-CES1    human-ABHD12
DO264 1-[1-[3-chloro-4-[2-chloro-4-(trifluoromethoxy)phenoxy]pyridin-2-yl]piperidin-4-yl]-3-pyridin-3-ylthiourea human-ABHD12
Dihydrobetulonic-acid (1S,3aS,5aR,5bR,7aR,11aR,11bR,13aR,13bR)-5a,5b,8,8,11a-pentamethyl-9-oxo-1-propan-2-yl-2,3,4,5,6,7,7a,10,11,11b,12,13,13a,13b-tetradecahydro-1H-cyclopenta[a]chrysene-3a-carboxylic acid human-ABHD12
Maslinic-acid (4aS,6aR,6aS,6bR,8aR,10R,11R,12aR,14bS)-10,11-dihydroxy-2,2,6a,6b,9,9,12a-heptamethyl-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid human-ABHD12
Ursolic-acid 3Beta-Hydroxy-12-ursen-28-oic Acid\; 3beta-Hydroxyurs-12-en-28-oic acid human-ABHD12

References (10)

Title : Bioinformatics Analysis Identifies Sequence Determinants of Enzymatic Activity for the PHARC-Associated Lipase ABHD12 - Chakraborty_2025_Biochemistry__
Author(s) : Chakraborty A , Devarajan A , Kumar K , C SR , Madhusudhan MS , Ratnaparkhi GS , Kamat SS
Ref : Biochemistry , : , 2025
Abstract :
PubMedSearch : Chakraborty_2025_Biochemistry__
PubMedID: 40138185
Gene_locus related to this paper: drome-CG15111 , human-ABHD12 , mouse-abd12

Title : Fatty acid chain length drives lysophosphatidylserine-dependent immunological outputs - Khandelwal_2021_Cell.Chem.Biol__
Author(s) : Khandelwal N , Shaikh M , Mhetre A , Singh S , Sajeevan T , Joshi A , Balaji KN , Chakrapani H , Kamat SS
Ref : Cell Chemical Biology , : , 2021
Abstract :
PubMedSearch : Khandelwal_2021_Cell.Chem.Biol__
PubMedID: 33571455
Gene_locus related to this paper: human-ABHD12

Title : Mapping the neuroanatomy of ABHD16A-ABHD12 & lysophosphatidylserines provides new insights into the pathophysiology of the human neurological disorder PHARC - Singh_2020_Biochemistry_59_2299
Author(s) : Singh S , Joshi A , Kamat SS
Ref : Biochemistry , 59 :2299 , 2020
Abstract :
PubMedSearch : Singh_2020_Biochemistry_59_2299
PubMedID: 32462874
Gene_locus related to this paper: human-ABHD12 , human-ABHD16A

Title : A chemical-genetic screen identifies ABHD12 as an oxidized-phosphatidylserine lipase - Kelkar_2019_Nat.Chem.Biol_15_169
Author(s) : Kelkar DS , Ravikumar G , Mehendale N , Singh S , Joshi A , Sharma AK , Mhetre A , Rajendran A , Chakrapani H , Kamat SS
Ref : Nat Chemical Biology , 15 :169 , 2019
Abstract :
PubMedSearch : Kelkar_2019_Nat.Chem.Biol_15_169
PubMedID: 30643283
Gene_locus related to this paper: human-ABHD12

Title : Structural properties and role of the endocannabinoid lipases ABHD6 and ABHD12 in lipid signalling and disease - Kind_2019_Amino.Acids_51_151
Author(s) : Kind L , Kursula P
Ref : Amino Acids , 51 :151 , 2018
Abstract :
PubMedSearch : Kind_2019_Amino.Acids_51_151
PubMedID: 30564946
Gene_locus related to this paper: human-ABHD6 , human-ABHD12

Title : Biochemical characterization of the PHARC-associated serine hydrolase ABHD12 reveals its preference for very-long-chain lipids - Joshi_2018_J.Biol.Chem_293_16953
Author(s) : Joshi A , Shaikh M , Singh S , Rajendran A , Mhetre A , Kamat SS
Ref : Journal of Biological Chemistry , 293 :16953 , 2018
Abstract :
PubMedSearch : Joshi_2018_J.Biol.Chem_293_16953
PubMedID: 30237167
Gene_locus related to this paper: human-ABHD12

Title : Immunomodulatory lysophosphatidylserines are regulated by ABHD16A and ABHD12 interplay - Kamat_2015_Nat.Chem.Biol_11_164
Author(s) : Kamat SS , Camara K , Parsons WH , Chen DH , Dix MM , Bird TD , Howell AR , Cravatt BF
Ref : Nat Chemical Biology , 11 :164 , 2015
Abstract :
PubMedSearch : Kamat_2015_Nat.Chem.Biol_11_164
PubMedID: 25580854
Gene_locus related to this paper: human-ABHD12 , human-ABHD16A , mouse-abd12 , mouse-Abhd16a

Title : ABHD12 controls brain lysophosphatidylserine pathways that are deregulated in a murine model of the neurodegenerative disease PHARC - Blankman_2013_Proc.Natl.Acad.Sci.U.S.A_110_1500
Author(s) : Blankman JL , Long JZ , Trauger SA , Siuzdak G , Cravatt BF
Ref : Proc Natl Acad Sci U S A , 110 :1500 , 2013
Abstract :
PubMedSearch : Blankman_2013_Proc.Natl.Acad.Sci.U.S.A_110_1500
PubMedID: 23297193
Gene_locus related to this paper: human-ABHD12

Title : Mutations in ABHD12 cause the neurodegenerative disease PHARC: An inborn error of endocannabinoid metabolism - Fiskerstrand_2010_Am.J.Hum.Genet_87_410
Author(s) : Fiskerstrand T , H'Mida-Ben Brahim D , Johansson S , M'Zahem A , Haukanes BI , Drouot N , Zimmermann J , Cole AJ , Vedeler C , Bredrup C , Assoum M , Tazir M , Klockgether T , Hamri A , Steen VM , Boman H , Bindoff LA , Koenig M , Knappskog PM
Ref : American Journal of Human Genetics , 87 :410 , 2010
Abstract :
PubMedSearch : Fiskerstrand_2010_Am.J.Hum.Genet_87_410
PubMedID: 20797687
Gene_locus related to this paper: human-ABHD12

Title : A comprehensive profile of brain enzymes that hydrolyze the endocannabinoid 2-arachidonoylglycerol - Blankman_2007_Chem.Biol_14_1347
Author(s) : Blankman JL , Simon GM , Cravatt BF
Ref : Chemical Biology , 14 :1347 , 2007
Abstract :
PubMedSearch : Blankman_2007_Chem.Biol_14_1347
PubMedID: 18096503
Gene_locus related to this paper: human-ABHD6 , human-ABHD12 , human-MGLL