Phospholipase

Relationship

Family: Phospholipase

Block: L

Parent Family: No family

Comment

Phospholipase A(1) (PLA(1)) is an enzyme that hydrolyzes phospholipids and produces 2-acyl-lysophospholipids and fatty acids and is conserved in a wide range of organisms. Hypotrichosis, or woolly hair with or without hypotrichosis hypotrichosis (deficiency of hair growth), can be caused by homozygous or compound heterozygous mutation in the LIPH (human-LIPH) gene on chromosome 3q27 (not hepatic lipase: human-LIPC). Other mammalian enzymes that exhibit PLA(1) activity in vitro are hepatic lipase HL endothelial lipase EL and pancreatic lipase-related protein 2 PLRP2 and belong to alpha/beta hydrolase superfamily.

Database

Interpro : IPR000734 Lipase , IPR002334 Dol\/Ves 1 allergen , IPR016272 Lipase, LIPH-type , IPR013818 Lipase

PIRSF : PIRSF000865 lipoprotein lipase, LIPH type

Pdoc : PDOC00110

Pfam : PF00151 Lipase

Prints : PR00821 , PR00825

EC Number : 3.1.1.32

Sequences

Peptide in Fasta
Nucleotide in Fasta
Alignment with Multalin Text only
Seed alignment with MAFFT No colour
Alignment with MAFFT No colour
Dendrogram The dnd file

No structure scheme yet for this family

Genes Proteins in Phospholipase family (277)

Fragments of genes in Phospholipase family (19)

No fragment of genes

Substrates in Phospholipase family (5)

No Inhibitor

References (3)

Title : The Lysophosphatidylserines-An Emerging Class of Signalling Lysophospholipids - Shanbhag_2020_J.Membr.Biol_253_381
Author(s) : Shanbhag K , Mhetre A , Khandelwal N , Kamat SS
Ref : J Membr Biol , 253 :381 , 2020
PubMedID: 32767057

Title : Structure and function of extracellular phospholipase A1 belonging to the pancreatic lipase gene family - Aoki_2007_Biochimie_89_197
Author(s) : Aoki J , Inoue A , Makide K , Saiki N , Arai H
Ref : Biochimie , 89 :197 , 2007
PubMedID: 17101204

Title : An alternative splicing form of phosphatidylserine-specific phospholipase A1 that exhibits lysophosphatidylserine-specific lysophospholipase activity in humans - Nagai_1999_J.Biol.Chem_274_11053
Author(s) : Nagai Y , Aoki J , Sato T , Amano K , Matsuda Y , Arai H and
Ref : Journal of Biological Chemistry , 274 :11053 , 1999
PubMedID: 10196188
Gene_locus related to this paper: human-PLA1A