Trandolapril
General
Type : Not A\/B H target || Drug || Pro-Drug || Pyrrolidine || Angiotensin-converting enzyme inhibitor
Chemical_Nomenclature : (2S,3aR,7aS)-1-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]-2,3,3a,4,5,6,7,7a-octahydroindole-2-carboxylic acid
Canonical SMILES : CCOC(=O)C(CCC1=CC=CC=C1)NC(C)C(=O)N2C3CCCCC3CC2C(=O)O
InChI : InChI=1S\/C24H34N2O5\/c1-3-31-24(30)19(14-13-17-9-5-4-6-10-17)25-16(2)22(27)26-20-12-8-7-11-18(20)15-21(26)23(28)29\/h4-6,9-10,16,18-21,25H,3,7-8,11-15H2,1-2H3,(H,28,29)\/t16-,18+,19-,20-,21-\/m0\/s1
InChIKey : VXFJYXUZANRPDJ-WTNASJBWSA-N
Other name(s) : Mavik, Gopten, Odrik, CHEMBL1519, SCHEMBL16610, CHEBI:9649
Target
Families : Carb_B_Chordata
References (5)
| Title : Impact of carboxylesterase 1 genetic polymorphism on trandolapril activation in human liver and the pharmacokinetics and pharmacodynamics in healthy volunteers - Wang_2021_Clin.Transl.Sci__ |
| Author(s) : Wang X , Her L , Xiao J , Shi J , Wu AH , Bleske BE , Zhu HJ |
| Ref : Clin Transl Sci , : , 2021 |
| Abstract : Wang_2021_Clin.Transl.Sci__ |
| ESTHER : Wang_2021_Clin.Transl.Sci__ |
| PubMedSearch : Wang_2021_Clin.Transl.Sci__ |
| PubMedID: 33660934 |
| Title : CES1P1 variant -816A>C is not associated with hepatic carboxylesterase 1 expression and activity or antihypertensive effect of trandolapril - Zhu_2016_Eur.J.Clin.Pharmacol_72_681 |
| Author(s) : Zhu HJ , Langaee TY , Gong Y , Wang X , Pepine CJ , Cooper-DeHoff RM , Johnson JA , Markowitz JS |
| Ref : European Journal of Clinical Pharmacology , 72 :681 , 2016 |
| Abstract : Zhu_2016_Eur.J.Clin.Pharmacol_72_681 |
| ESTHER : Zhu_2016_Eur.J.Clin.Pharmacol_72_681 |
| PubMedSearch : Zhu_2016_Eur.J.Clin.Pharmacol_72_681 |
| PubMedID: 26915813 |
| Gene_locus related to this paper: human-CES1 |
| Title : In vitro drug metabolism by human carboxylesterase 1: focus on Angiotensin-converting enzyme inhibitors - Thomsen_2014_Drug.Metab.Dispos_42_126 |
| Author(s) : Thomsen R , Rasmussen HB , Linnet K |
| Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , 42 :126 , 2014 |
| Abstract : Thomsen_2014_Drug.Metab.Dispos_42_126 |
| ESTHER : Thomsen_2014_Drug.Metab.Dispos_42_126 |
| PubMedSearch : Thomsen_2014_Drug.Metab.Dispos_42_126 |
| PubMedID: 24141856 |
| Gene_locus related to this paper: human-CES1 |
| Title : Clopidogrel Bioactivation and Risk of Bleeding in Patients Cotreated With Angiotensin-Converting Enzyme Inhibitors After Myocardial Infarction: A Proof-of-Concept Study - Kristensen_2014_Clin.Pharmacol.Ther_96_713 |
| Author(s) : Kristensen KE , Zhu HJ , Wang X , Gislason GH , Torp-Pedersen C , Rasmussen HB , Markowitz JS , Hansen PR |
| Ref : Clinical Pharmacology & Therapeutics , 96 :713 , 2014 |
| Abstract : Kristensen_2014_Clin.Pharmacol.Ther_96_713 |
| ESTHER : Kristensen_2014_Clin.Pharmacol.Ther_96_713 |
| PubMedSearch : Kristensen_2014_Clin.Pharmacol.Ther_96_713 |
| PubMedID: 25222620 |
| Title : Role of carboxylesterase 1 and impact of natural genetic variants on the hydrolysis of trandolapril - Zhu_2009_Biochem.Pharmacol_77_1266 |
| Author(s) : Zhu HJ , Appel DI , Johnson JA , Chavin KD , Markowitz JS |
| Ref : Biochemical Pharmacology , 77 :1266 , 2009 |
| Abstract : Zhu_2009_Biochem.Pharmacol_77_1266 |
| ESTHER : Zhu_2009_Biochem.Pharmacol_77_1266 |
| PubMedSearch : Zhu_2009_Biochem.Pharmacol_77_1266 |
| PubMedID: 19185566 |
| Gene_locus related to this paper: human-CES1 |